Dynamic remodelling of the endoplasmic reticulum for mitosis
The endoplasmic reticulum (ER) is a dynamic and continuous membrane network with roles in many cellular processes. The importance and maintenance of ER structure and function have been extensively studied in interphase cells, yet recent findings also indicate crucial roles of the ER in mitosis. Duri...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2024
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| In: |
Journal of cell science
Year: 2024, Volume: 137, Issue: 22, Pages: 1-10 |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.261444 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1242/jcs.261444
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| Author Notes: | Suzan Kors and Anne-Lore Schlaitz |
| Summary: | The endoplasmic reticulum (ER) is a dynamic and continuous membrane network with roles in many cellular processes. The importance and maintenance of ER structure and function have been extensively studied in interphase cells, yet recent findings also indicate crucial roles of the ER in mitosis. During mitosis, the ER is remodelled significantly with respect to composition and morphology but persists as a continuous network. The ER interacts with microtubules, actin and intermediate filaments, and concomitant with the mitotic restructuring of all cytoskeletal systems, ER dynamics and distribution change. The ER is a metabolic hub and several examples of altered ER functions during mitosis have been described. However, we lack an overall understanding of the ER metabolic pathways and functions that are active during mitosis. In this Review, we will discuss mitotic changes to the ER at different organizational levels to explore how the mitotic ER, with its distinct properties, might support cell division. |
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| Item Description: | Veröffentlicht: 25. November 2024 Gesehen am 03.03.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1477-9137 |
| DOI: | 10.1242/jcs.261444 |