Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein
Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding, internalization, transmission, and toxicity of pathologic α-...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
31 May 2024
|
| In: |
Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-19 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-024-49016-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-49016-3
|
| Verfasserangaben: | Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson & Ted M. Dawson |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1918887594 | ||
| 003 | DE-627 | ||
| 005 | 20250716234750.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250303s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41467-024-49016-3 |2 doi | |
| 035 | |a (DE-627)1918887594 | ||
| 035 | |a (DE-599)KXP1918887594 | ||
| 035 | |a (OCoLC)1528019625 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Mao, Xiaobo |e VerfasserIn |0 (DE-588)1358422648 |0 (DE-627)1918888876 |4 aut | |
| 245 | 1 | 0 | |a Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein |c Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson & Ted M. Dawson |
| 264 | 1 | |c 31 May 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.03.2025 | ||
| 520 | |a Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding, internalization, transmission, and toxicity of pathologic α-syn. Deletion of both Aplp1 and Lag3 eliminates the loss of dopaminergic neurons and the accompanying behavioral deficits induced by α-syn preformed fibrils (PFF). Anti-Lag3 prevents the internalization of α-syn PFF by disrupting the interaction of Aplp1 and Lag3, and blocks the neurodegeneration induced by α-syn PFF in vivo. The identification of Aplp1 and the interplay with Lag3 for α-syn PFF induced pathology deepens our insight about molecular mechanisms of cell-to-cell transmission of pathologic α-syn and provides additional targets for therapeutic strategies aimed at preventing neurodegeneration in Parkinson's disease and related α-synucleinopathies. | ||
| 650 | 4 | |a alpha-Synuclein | |
| 650 | 4 | |a Amyloid beta-Protein Precursor | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Antigens, CD | |
| 650 | 4 | |a Dopaminergic Neurons | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Lymphocyte Activation Gene 3 Protein | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mice, Inbred C57BL | |
| 650 | 4 | |a Mice, Knockout | |
| 650 | 4 | |a Parkinson Disease | |
| 650 | 4 | |a Protein Binding | |
| 700 | 1 | |a Gu, Hao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kim, Donghoon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kimura, Yasuyoshi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Ning |e VerfasserIn |4 aut | |
| 700 | 1 | |a Xu, Enquan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kumbhar, Ramhari |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ming, Xiaotian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wang, Haibo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Chan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Shengnan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jia, Chunyu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Liu, Yuqing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bian, Hetao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Karuppagounder, Senthilkumar S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Akkentli, Fatih |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Qi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jia, Longgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hwang, Heehong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee, Su Hyun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ke, Xiyu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chang, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Li, Amanda |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yang, Jun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rastegar, Cyrus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sriparna, Manjari |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ge, Preston |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brahmachari, Saurav |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kim, Sangjune |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Shu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shimoda, Yasushi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saar, Martina |e VerfasserIn |0 (DE-588)1025145240 |0 (DE-627)721336698 |0 (DE-576)370013689 |4 aut | |
| 700 | 1 | |a Liu, Haiqing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kweon, Sin Ho |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ying, Mingyao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Workman, Creg J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vignali, Dario A. A. |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Müller, Ulrike C. |d 1960- |e VerfasserIn |0 (DE-588)1020647965 |0 (DE-627)691291403 |0 (DE-576)361723210 |4 aut | |
| 700 | 1 | |a Liu, Cong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ko, Han Seok |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dawson, Valina L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dawson, Ted M. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature Communications |d [London] : Springer Nature, 2010 |g 15(2024), Artikel-ID 4663, Seite 1-19 |h Online-Ressource |w (DE-627)626457688 |w (DE-600)2553671-0 |w (DE-576)331555905 |x 2041-1723 |7 nnas |a Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein |
| 773 | 1 | 8 | |g volume:15 |g year:2024 |g elocationid:4663 |g pages:1-19 |g extent:19 |a Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41467-024-49016-3 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250403 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250303 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1025145240 |a Saar, Martina |m 1025145240:Saar, Martina |p 32 | ||
| 999 | |a KXP-PPN1918887594 |e 4680495944 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1918887594","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 03.03.2025"],"title":[{"title":"Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein","title_sort":"Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synuclein"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Mao, Xiaobo","given":"Xiaobo","family":"Mao"},{"family":"Gu","given":"Hao","display":"Gu, Hao","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Kim","given":"Donghoon","display":"Kim, Donghoon","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Yasuyoshi","family":"Kimura","role":"aut","roleDisplay":"VerfasserIn","display":"Kimura, Yasuyoshi"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wang, Ning","given":"Ning","family":"Wang"},{"given":"Enquan","family":"Xu","role":"aut","roleDisplay":"VerfasserIn","display":"Xu, Enquan"},{"family":"Kumbhar","given":"Ramhari","roleDisplay":"VerfasserIn","display":"Kumbhar, Ramhari","role":"aut"},{"role":"aut","display":"Ming, Xiaotian","roleDisplay":"VerfasserIn","given":"Xiaotian","family":"Ming"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wang, Haibo","given":"Haibo","family":"Wang"},{"roleDisplay":"VerfasserIn","display":"Chen, Chan","role":"aut","family":"Chen","given":"Chan"},{"given":"Shengnan","family":"Zhang","role":"aut","roleDisplay":"VerfasserIn","display":"Zhang, Shengnan"},{"display":"Jia, Chunyu","roleDisplay":"VerfasserIn","role":"aut","family":"Jia","given":"Chunyu"},{"roleDisplay":"VerfasserIn","display":"Liu, Yuqing","role":"aut","family":"Liu","given":"Yuqing"},{"roleDisplay":"VerfasserIn","display":"Bian, Hetao","role":"aut","family":"Bian","given":"Hetao"},{"family":"Karuppagounder","given":"Senthilkumar S.","roleDisplay":"VerfasserIn","display":"Karuppagounder, Senthilkumar S.","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Akkentli, Fatih","given":"Fatih","family":"Akkentli"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Chen, Qi","given":"Qi","family":"Chen"},{"family":"Jia","given":"Longgang","roleDisplay":"VerfasserIn","display":"Jia, Longgang","role":"aut"},{"family":"Hwang","given":"Heehong","roleDisplay":"VerfasserIn","display":"Hwang, Heehong","role":"aut"},{"family":"Lee","given":"Su Hyun","display":"Lee, Su Hyun","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Xiyu","family":"Ke","role":"aut","display":"Ke, Xiyu","roleDisplay":"VerfasserIn"},{"given":"Michael","family":"Chang","role":"aut","roleDisplay":"VerfasserIn","display":"Chang, Michael"},{"given":"Amanda","family":"Li","role":"aut","display":"Li, Amanda","roleDisplay":"VerfasserIn"},{"family":"Yang","given":"Jun","roleDisplay":"VerfasserIn","display":"Yang, Jun","role":"aut"},{"family":"Rastegar","given":"Cyrus","roleDisplay":"VerfasserIn","display":"Rastegar, Cyrus","role":"aut"},{"family":"Sriparna","given":"Manjari","roleDisplay":"VerfasserIn","display":"Sriparna, Manjari","role":"aut"},{"given":"Preston","family":"Ge","role":"aut","display":"Ge, Preston","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Brahmachari, Saurav","role":"aut","family":"Brahmachari","given":"Saurav"},{"display":"Kim, Sangjune","roleDisplay":"VerfasserIn","role":"aut","family":"Kim","given":"Sangjune"},{"family":"Zhang","given":"Shu","display":"Zhang, Shu","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Shimoda, Yasushi","roleDisplay":"VerfasserIn","role":"aut","family":"Shimoda","given":"Yasushi"},{"role":"aut","display":"Saar, Martina","roleDisplay":"VerfasserIn","given":"Martina","family":"Saar"},{"family":"Liu","given":"Haiqing","roleDisplay":"VerfasserIn","display":"Liu, Haiqing","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Kweon, Sin Ho","role":"aut","family":"Kweon","given":"Sin Ho"},{"given":"Mingyao","family":"Ying","role":"aut","roleDisplay":"VerfasserIn","display":"Ying, Mingyao"},{"family":"Workman","given":"Creg J.","display":"Workman, Creg J.","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Dario A. A.","family":"Vignali","role":"aut","display":"Vignali, Dario A. A.","roleDisplay":"VerfasserIn"},{"display":"Müller, Ulrike C.","roleDisplay":"VerfasserIn","role":"aut","family":"Müller","given":"Ulrike C."},{"given":"Cong","family":"Liu","role":"aut","display":"Liu, Cong","roleDisplay":"VerfasserIn"},{"display":"Ko, Han Seok","roleDisplay":"VerfasserIn","role":"aut","family":"Ko","given":"Han Seok"},{"family":"Dawson","given":"Valina L.","display":"Dawson, Valina L.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Dawson","given":"Ted M.","display":"Dawson, Ted M.","roleDisplay":"VerfasserIn","role":"aut"}],"relHost":[{"title":[{"title_sort":"Nature Communications","title":"Nature Communications"}],"part":{"volume":"15","text":"15(2024), Artikel-ID 4663, Seite 1-19","extent":"19","year":"2024","pages":"1-19"},"pubHistory":["2010-"],"language":["eng"],"recId":"626457688","note":["Gesehen am 13.06.24"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Aplp1 interacts with Lag3 to facilitate transmission of pathologic α-synucleinNature Communications","id":{"zdb":["2553671-0"],"eki":["626457688"],"issn":["2041-1723"]},"origin":[{"publisherPlace":"[London] ; [London]","dateIssuedDisp":"[2010]-","publisher":"Springer Nature ; Nature Publishing Group UK"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"19 S."}],"id":{"doi":["10.1038/s41467-024-49016-3"],"eki":["1918887594"]},"origin":[{"dateIssuedDisp":"31 May 2024","dateIssuedKey":"2024"}],"name":{"displayForm":["Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson & Ted M. Dawson"]}} | ||
| SRT | |a MAOXIAOBOGAPLP1INTER3120 | ||