Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination
Memory B cells (MBCs) formed over the individual’s lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens, but how they respond to recognition of novel antigens is not well understood. Here, we track...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 September 2024
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| In: |
Immunity
Year: 2024, Jahrgang: 57, Heft: 9, Pages: 2191-2201.e1-e5 |
| ISSN: | 1097-4180 |
| DOI: | 10.1016/j.immuni.2024.07.023 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.immuni.2024.07.023 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761324003728 
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| Verfasserangaben: | Zhe Li, Anna Obraztsova, Fuwei Shang, Opeyemi Ernest Oludada, Joshua Malapit, Katrin Busch, Monique van Straaten, Erec Stebbins, Rajagopal Murugan, and Hedda Wardemann |
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| 245 | 1 | 0 | |a Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination |c Zhe Li, Anna Obraztsova, Fuwei Shang, Opeyemi Ernest Oludada, Joshua Malapit, Katrin Busch, Monique van Straaten, Erec Stebbins, Rajagopal Murugan, and Hedda Wardemann |
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| 520 | |a Memory B cells (MBCs) formed over the individual’s lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens, but how they respond to recognition of novel antigens is not well understood. Here, we tracked the origin and followed the differentiation paths of MBCs in the early anti-spike (S) response to mRNA vaccination in SARS-CoV-2-naive individuals on single-cell and monoclonal antibody levels. Pre-existing, highly mutated MBCs showed no signs of germinal center re-entry and rapidly developed into mature antibody-secreting cells (ASCs). By contrast, and despite similar levels of S reactivity, naive B cells showed strong signs of antibody affinity maturation before differentiating into MBCs and ASCs. Thus, pre-existing human MBCs differentiate into ASCs in response to novel antigens, but the quality of the humoral and cellular anti-S response improved through the clonal selection and affinity maturation of naive precursors. | ||
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| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a somatic hypermutation | |
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