The lymphatic vascular system in extracellular vesicle-mediated tumor progression
Tumor growth and progression require molecular interactions between malignant and host cells. In recent years, extracellular vesicles (EVs) emerged as an important pillar of such interactions, carrying molecular information from their donor cells to distant recipient cells. Thereby, the phenotype an...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 December 2024
|
| In: |
Cancers
Year: 2024, Volume: 16, Issue: 23, Pages: 1-19 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16234039 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16234039 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/23/4039 
|
| Author Notes: | Pragati Lodha, Alperen Acari, Jochen Rieck, Sarah Hofmann and Lothar C. Dieterich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 191913932X | ||
| 003 | DE-627 | ||
| 005 | 20250716235259.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250305s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers16234039 |2 doi | |
| 035 | |a (DE-627)191913932X | ||
| 035 | |a (DE-599)KXP191913932X | ||
| 035 | |a (OCoLC)1528020200 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lodha, Pragati |e VerfasserIn |0 (DE-588)1358712298 |0 (DE-627)1919139966 |4 aut | |
| 245 | 1 | 4 | |a The lymphatic vascular system in extracellular vesicle-mediated tumor progression |c Pragati Lodha, Alperen Acari, Jochen Rieck, Sarah Hofmann and Lothar C. Dieterich |
| 264 | 1 | |c 2 December 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.03.2025 | ||
| 520 | |a Tumor growth and progression require molecular interactions between malignant and host cells. In recent years, extracellular vesicles (EVs) emerged as an important pillar of such interactions, carrying molecular information from their donor cells to distant recipient cells. Thereby, the phenotype and function of the recipient cells are altered, which may facilitate tumor immune escape and tumor metastasis to other organs through the formation of pre-metastatic niches. A prerequisite for these effects of tumor cell-derived EVs is an efficient transport system from the site of origin to the body periphery. Here, we highlight the role of the lymphatic vascular system in the distribution and progression-promoting functions of tumor cell-derived EVs. Importantly, the lymphatic vascular system is the primary drainage system for interstitial fluid and its soluble, particulate, and cellular contents, and therefore represents the principal route for regional (i.e., to tumor-draining lymph nodes) and systemic distribution of EVs derived from solid tumors. Furthermore, recent studies highlighted the tumor-draining lymph node as a crucial site where tumor-derived EVs exert their effects. A deeper mechanistic understanding of how EVs gain access to the lymphatic vasculature, how they interact with their recipient cells in tumor-draining lymph nodes and beyond, and how they induce phenotypic and functional maladaptation will be instrumental to identify new molecular targets and conceive innovative approaches for cancer therapy. | ||
| 650 | 4 | |a lymph node | |
| 650 | 4 | |a lymphatic drainage | |
| 650 | 4 | |a lymphatic transport | |
| 650 | 4 | |a pre-metastatic niche | |
| 650 | 4 | |a tumor immunity | |
| 700 | 1 | |a Acari, Alperen |e VerfasserIn |0 (DE-588)1358712662 |0 (DE-627)1919140409 |4 aut | |
| 700 | 1 | |a Rieck, Jochen |d 1971- |e VerfasserIn |0 (DE-588)1027605729 |0 (DE-627)729468402 |0 (DE-576)373458665 |4 aut | |
| 700 | 1 | |a Hofmann, Sarah |e VerfasserIn |0 (DE-588)107448584X |0 (DE-627)832262692 |0 (DE-576)442713851 |4 aut | |
| 700 | 1 | |a Dieterich, Lothar |d 1979- |e VerfasserIn |0 (DE-588)1288643764 |0 (DE-627)1844783901 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 16(2024), 23, Artikel-ID 4039, Seite 1-19 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a The lymphatic vascular system in extracellular vesicle-mediated tumor progression |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:23 |g elocationid:4039 |g pages:1-19 |g extent:19 |a The lymphatic vascular system in extracellular vesicle-mediated tumor progression |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers16234039 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/16/23/4039 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250305 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1288643764 |a Dieterich, Lothar |m 1288643764:Dieterich, Lothar |d 60000 |d 65000 |e 60000PD1288643764 |e 65000PD1288643764 |k 0/60000/ |k 1/60000/65000/ |p 5 |y j | ||
| 998 | |g 107448584X |a Hofmann, Sarah |m 107448584X:Hofmann, Sarah |d 60000 |d 65000 |e 60000PH107448584X |e 65000PH107448584X |k 0/60000/ |k 1/60000/65000/ |p 4 | ||
| 998 | |g 1027605729 |a Rieck, Jochen |m 1027605729:Rieck, Jochen |d 60000 |d 65000 |e 60000PR1027605729 |e 65000PR1027605729 |k 0/60000/ |k 1/60000/65000/ |p 3 | ||
| 998 | |g 1358712662 |a Acari, Alperen |m 1358712662:Acari, Alperen |d 60000 |d 65000 |e 60000PA1358712662 |e 65000PA1358712662 |k 0/60000/ |k 1/60000/65000/ |p 2 | ||
| 998 | |g 1358712298 |a Lodha, Pragati |m 1358712298:Lodha, Pragati |d 60000 |d 65000 |e 60000PL1358712298 |e 65000PL1358712298 |k 0/60000/ |k 1/60000/65000/ |p 1 |x j | ||
| 999 | |a KXP-PPN191913932X |e 4682922297 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.3390/cancers16234039"],"eki":["191913932X"]},"recId":"191913932X","name":{"displayForm":["Pragati Lodha, Alperen Acari, Jochen Rieck, Sarah Hofmann and Lothar C. Dieterich"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","family":"Lodha","roleDisplay":"VerfasserIn","display":"Lodha, Pragati","given":"Pragati"},{"display":"Acari, Alperen","roleDisplay":"VerfasserIn","given":"Alperen","family":"Acari","role":"aut"},{"role":"aut","display":"Rieck, Jochen","roleDisplay":"VerfasserIn","given":"Jochen","family":"Rieck"},{"role":"aut","family":"Hofmann","display":"Hofmann, Sarah","roleDisplay":"VerfasserIn","given":"Sarah"},{"role":"aut","family":"Dieterich","roleDisplay":"VerfasserIn","display":"Dieterich, Lothar","given":"Lothar"}],"title":[{"title":"The lymphatic vascular system in extracellular vesicle-mediated tumor progression","title_sort":"lymphatic vascular system in extracellular vesicle-mediated tumor progression"}],"origin":[{"dateIssuedDisp":"2 December 2024","dateIssuedKey":"2024"}],"physDesc":[{"noteIll":"Illustrationen","extent":"19 S."}],"relHost":[{"title":[{"title_sort":"Cancers","title":"Cancers"}],"part":{"extent":"19","text":"16(2024), 23, Artikel-ID 4039, Seite 1-19","volume":"16","issue":"23","pages":"1-19","year":"2024"},"type":{"bibl":"periodical","media":"Online-Ressource"},"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"pubHistory":["1.2009 -"],"recId":"614095670","id":{"eki":["614095670"],"zdb":["2527080-1"],"issn":["2072-6694"]},"language":["eng"],"disp":"The lymphatic vascular system in extracellular vesicle-mediated tumor progressionCancers","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 27.05.2020"],"origin":[{"publisherPlace":"Basel","dateIssuedDisp":"2009-","publisher":"MDPI","dateIssuedKey":"2009"}]}],"note":["Gesehen am 05.03.2025"],"language":["eng"]} | ||
| SRT | |a LODHAPRAGALYMPHATICV2202 | ||