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The role of TAM receptors in bone

The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rh...

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Bibliographic Details
Main Authors: Engelmann, Janik (Author) , Ragipoglu, Deniz (Author) , Ben-Batalla, Isabel (Author) , Loges, Sonja (Author)
Format: Article (Journal)
Language:English
Published: 2024
In: International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 1, Pages: 1-22
ISSN:1422-0067
DOI:10.3390/ijms25010233
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25010233
Verlag, kostenfrei, Volltext: https://www.mdpi.com/1422-0067/25/1/233
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Author Notes:Janik Engelmann, Deniz Ragipoglu, Isabel Ben-Batalla and Sonja Loges
Description
Summary:The TAM (TYRO3, MERTK, and AXL) family of receptor tyrosine kinases are pleiotropic regulators of adult tissue homeostasis maintaining organ integrity and self-renewal. Disruption of their homeostatic balance fosters pathological conditions like autoinflammatory or degenerative diseases including rheumatoid arthritis, lupus erythematodes, or liver fibrosis. Moreover, TAM receptors exhibit prominent cell-transforming properties, promoting tumor progression, metastasis, and therapy resistance in various cancer entities. Emerging evidence shows that TAM receptors are involved in bone homeostasis by regulating osteoblastic bone formation and osteoclastic bone resorption. Therefore, TAM receptors emerge as new key players of the regulatory cytokine network of osteoblasts and osteoclasts and represent accessible targets for pharmacologic therapy for a broad set of different bone diseases, including primary and metastatic bone tumors, rheumatoid arthritis, or osteoporosis.
Item Description:Online veröffentlicht: 23. Dezember 2023
Gesehen am 06.03.2025
Physical Description:Online Resource
ISSN:1422-0067
DOI:10.3390/ijms25010233

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