Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: a mechanism of immune evasion?
The CD95 (APO-1/Fas) system is an important mediator of T-cell cytotoxicity. We investigated this system in 22 hepatocellular carcinomas (HCCs) from patients. All HCCs had partially or completely lost the expression of the CD95 receptor constitutively expressed by normal liver cells and might thus e...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 December 1996
|
| In: |
Nature medicine
Year: 1996, Jahrgang: 2, Heft: 12, Pages: 1361-1366 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm1296-1361 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nm1296-1361 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nm1296-1361 
|
| Verfasserangaben: | Susanne Strand, Walter J. Hofmann, Hubert Hug, Martina Müller, Gerd Otto, Dennis Strand, Sara M. Mariani, Wolfgang Stremmel, Peter H. Krammer, Peter R. Galle |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1919243305 | ||
| 003 | DE-627 | ||
| 005 | 20250716235514.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250306s1996 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/nm1296-1361 |2 doi | |
| 035 | |a (DE-627)1919243305 | ||
| 035 | |a (DE-599)KXP1919243305 | ||
| 035 | |a (OCoLC)1528020041 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Strand, Susanne |e VerfasserIn |0 (DE-588)114491453 |0 (DE-627)510693245 |0 (DE-576)289798892 |4 aut | |
| 245 | 1 | 0 | |a Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells |b a mechanism of immune evasion? |c Susanne Strand, Walter J. Hofmann, Hubert Hug, Martina Müller, Gerd Otto, Dennis Strand, Sara M. Mariani, Wolfgang Stremmel, Peter H. Krammer, Peter R. Galle |
| 264 | 1 | |c 01 December 1996 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.03.2025 | ||
| 520 | |a The CD95 (APO-1/Fas) system is an important mediator of T-cell cytotoxicity. We investigated this system in 22 hepatocellular carcinomas (HCCs) from patients. All HCCs had partially or completely lost the expression of the CD95 receptor constitutively expressed by normal liver cells and might thus evade CD95-mediated killing. We also considered a new mechanism of immune evasion, namely, the active destruction of T-lymphocytes by tumor cells expressing CD95 ligand (CD95L). CD95L messenger RNA and protein could be detected in the HCCs. In coculture experiments, HepG2 hepatoblastoma cells, expressing CD95L mRNA after treatment with cytostatic drugs, killed CD95+ Jurkat lymphocytes. Our data suggest that tumor cells can evade immune attack by down-regulation of the CD95 receptor and killing of lymphocytes through expression of CD95L. | ||
| 650 | 4 | |a Biomedicine | |
| 650 | 4 | |a Cancer Research | |
| 650 | 4 | |a general | |
| 650 | 4 | |a Infectious Diseases | |
| 650 | 4 | |a Metabolic Diseases | |
| 650 | 4 | |a Molecular Medicine | |
| 650 | 4 | |a Neurosciences | |
| 700 | 1 | |a Hofmann, Walter J. |e VerfasserIn |0 (DE-588)1106270622 |0 (DE-627)862967171 |0 (DE-576)473959445 |4 aut | |
| 700 | 1 | |a Hug, Hubert |d 1959- |e VerfasserIn |0 (DE-588)122638182 |0 (DE-627)705980782 |0 (DE-576)293359350 |4 aut | |
| 700 | 1 | |a Müller-Schilling, Martina |e VerfasserIn |0 (DE-588)1075470811 |0 (DE-627)833291130 |0 (DE-576)184003237 |4 aut | |
| 700 | 1 | |a Otto, Gerd |d 1944- |e VerfasserIn |0 (DE-588)1235891895 |0 (DE-627)1761126156 |4 aut | |
| 700 | 1 | |a Strand, Dennis |e VerfasserIn |0 (DE-588)1231738812 |0 (DE-627)1755350732 |4 aut | |
| 700 | 1 | |a Mariani, Sara M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stremmel, Wolfgang |d 1952- |e VerfasserIn |0 (DE-588)142773638 |0 (DE-627)640118747 |0 (DE-576)33331560X |4 aut | |
| 700 | 1 | |a Krammer, Peter H. |d 1946- |e VerfasserIn |0 (DE-588)121766373 |0 (DE-627)081520255 |0 (DE-576)292873417 |4 aut | |
| 700 | 1 | |a Galle, Peter R. |d 1957- |e VerfasserIn |0 (DE-588)1111061963 |0 (DE-627)865474168 |0 (DE-576)475908953 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature medicine |d [New York, NY] : Springer Nature, 1995 |g 2(1996), 12, Seite 1361-1366 |h Online-Ressource |w (DE-627)301511640 |w (DE-600)1484517-9 |w (DE-576)288571274 |x 1546-170X |7 nnas |a Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells a mechanism of immune evasion? |
| 773 | 1 | 8 | |g volume:2 |g year:1996 |g number:12 |g pages:1361-1366 |g extent:6 |a Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells a mechanism of immune evasion? |
| 856 | 4 | 0 | |u https://doi.org/10.1038/nm1296-1361 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/nm1296-1361 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250306 | ||
| 993 | |a Article | ||
| 994 | |a 1996 | ||
| 998 | |g 122638182 |a Hug, Hubert |m 122638182:Hug, Hubert |d 700000 |d 706000 |e 700000PH122638182 |e 706000PH122638182 |k 0/700000/ |k 1/700000/706000/ |p 3 | ||
| 998 | |g 1111061963 |a Galle, Peter R. |m 1111061963:Galle, Peter R. |d 910000 |d 910100 |e 910000PG1111061963 |e 910100PG1111061963 |k 0/910000/ |k 1/910000/910100/ |p 10 |y j | ||
| 998 | |g 121766373 |a Krammer, Peter H. |m 121766373:Krammer, Peter H. |d 50000 |e 50000PK121766373 |k 0/50000/ |p 9 | ||
| 998 | |g 142773638 |a Stremmel, Wolfgang |m 142773638:Stremmel, Wolfgang |d 910000 |d 910100 |e 910000PS142773638 |e 910100PS142773638 |k 0/910000/ |k 1/910000/910100/ |p 8 | ||
| 998 | |g 1235891895 |a Otto, Gerd |m 1235891895:Otto, Gerd |d 910000 |d 910200 |e 910000PO1235891895 |e 910200PO1235891895 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1075470811 |a Müller-Schilling, Martina |m 1075470811:Müller-Schilling, Martina |d 910000 |d 910100 |e 910000PM1075470811 |e 910100PM1075470811 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1106270622 |a Hofmann, Walter J. |m 1106270622:Hofmann, Walter J. |d 910000 |d 912000 |e 910000PH1106270622 |e 912000PH1106270622 |k 0/910000/ |k 1/910000/912000/ |p 2 | ||
| 998 | |g 114491453 |a Strand, Susanne |m 114491453:Strand, Susanne |d 910000 |d 910100 |e 910000PS114491453 |e 910100PS114491453 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1919243305 |e 4683347237 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells","title":"Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells","subtitle":"a mechanism of immune evasion?"}],"person":[{"roleDisplay":"VerfasserIn","display":"Strand, Susanne","role":"aut","family":"Strand","given":"Susanne"},{"roleDisplay":"VerfasserIn","display":"Hofmann, Walter J.","role":"aut","family":"Hofmann","given":"Walter J."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Hug, Hubert","given":"Hubert","family":"Hug"},{"given":"Martina","family":"Müller-Schilling","role":"aut","display":"Müller-Schilling, Martina","roleDisplay":"VerfasserIn"},{"display":"Otto, Gerd","roleDisplay":"VerfasserIn","role":"aut","family":"Otto","given":"Gerd"},{"family":"Strand","given":"Dennis","display":"Strand, Dennis","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Mariani","given":"Sara M.","roleDisplay":"VerfasserIn","display":"Mariani, Sara M.","role":"aut"},{"given":"Wolfgang","family":"Stremmel","role":"aut","roleDisplay":"VerfasserIn","display":"Stremmel, Wolfgang"},{"role":"aut","display":"Krammer, Peter H.","roleDisplay":"VerfasserIn","given":"Peter H.","family":"Krammer"},{"given":"Peter R.","family":"Galle","role":"aut","roleDisplay":"VerfasserIn","display":"Galle, Peter R."}],"note":["Gesehen am 06.03.2025"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"recId":"1919243305","origin":[{"dateIssuedKey":"1996","dateIssuedDisp":"01 December 1996"}],"id":{"eki":["1919243305"],"doi":["10.1038/nm1296-1361"]},"name":{"displayForm":["Susanne Strand, Walter J. Hofmann, Hubert Hug, Martina Müller, Gerd Otto, Dennis Strand, Sara M. Mariani, Wolfgang Stremmel, Peter H. Krammer, Peter R. Galle"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"note":["Gesehen am 24. Juli 2018"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells a mechanism of immune evasion?Nature medicine","language":["eng"],"recId":"301511640","pubHistory":["1.1995 -"],"part":{"volume":"2","text":"2(1996), 12, Seite 1361-1366","extent":"6","year":"1996","pages":"1361-1366","issue":"12"},"title":[{"title_sort":"Nature medicine","title":"Nature medicine"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"2017-","dateIssuedKey":"2017","publisher":"Springer Nature ; Nature America Inc.","publisherPlace":"[New York, NY] ; New York, NY"}],"id":{"zdb":["1484517-9"],"eki":["301511640"],"issn":["1546-170X"]}}]} | ||
| SRT | |a STRANDSUSALYMPHOCYTE0119 | ||