Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia: an imaging genetics and independent replication approach
The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals with spider phobia. A replication approach was applied [discove...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 August 2024
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| In: |
Social cognitive and affective neuroscience
Year: 2024, Jahrgang: 19, Heft: 1, Pages: 1-11 |
| ISSN: | 1749-5024 |
| DOI: | 10.1093/scan/nsae054 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/scan/nsae054 Verlag, kostenfrei, Volltext: https://academic.oup.com/scan/article/19/1/nsae054/7738138?login=true 
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| Verfasserangaben: | Elisabeth J Leehr, Leonie S Brede, Joscha Böhnlein, Kati Roesmann, Bettina Gathmann, Martin J Herrmann, Markus Junghöfer, Hanna Schwarzmeier, Fabian R Seeger, Niklas Siminski, Thomas Straube, Anna Luisa Klahn, Heike Weber, Miriam A Schiele, Katharina Domschke, Ulrike Lueken, Udo Dannlowski |
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| 245 | 1 | 0 | |a Impact of NPSR1 gene variation on the neural correlates of phasic and sustained fear in spider phobia |b an imaging genetics and independent replication approach |c Elisabeth J Leehr, Leonie S Brede, Joscha Böhnlein, Kati Roesmann, Bettina Gathmann, Martin J Herrmann, Markus Junghöfer, Hanna Schwarzmeier, Fabian R Seeger, Niklas Siminski, Thomas Straube, Anna Luisa Klahn, Heike Weber, Miriam A Schiele, Katharina Domschke, Ulrike Lueken, Udo Dannlowski |
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| 520 | |a The functional neuropeptide S receptor 1 (NPSR1) gene A/T variant (rs324981) is associated with fear processing. We investigated the impact of NPSR1 genotype on fear processing and on symptom reduction following treatment in individuals with spider phobia. A replication approach was applied [discovery sample: Münster (MS) nMS = 104; replication sample Würzburg (WZ) nWZ = 81]. Participants were genotyped for NPSR1 rs324981 [T-allele carriers (risk) versus AA homozygotes (no-risk)]. A sustained and phasic fear paradigm was applied during functional magnetic resonance imaging. A one-session virtual reality exposure treatment was conducted. Change of symptom severity from pre to post treatment and within session fear reduction were assessed. T-allele carriers in the discovery sample displayed lower anterior cingulate cortex (ACC) activation compared to AA homozygotes independent of condition. For sustained fear, this effect was replicated within a small cluster and medium effect size. No association with symptom reduction was found. Within-session fear reduction was negatively associated with ACC activation in T-allele carriers in the discovery sample. NPSR1 rs324981 genotype might be associated with fear processing in the ACC in spider phobia. Interpretation as potential risk-increasing function of the NPSR1 rs324981 T-allele via impaired top-down control of limbic structures remains speculative. Potential association with symptom reduction warrants further research. | ||
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