Buchumschlag

Dose-response relationship in patients with liver metastases from neuroendocrine neoplasms undergoing radioembolization with 90Y glass microspheres: brief communication

The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment...

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Hauptverfasser: Watanabe, Masao (VerfasserIn) , Leyser, Stephan (VerfasserIn) , Theysohn, Jens (VerfasserIn) , Schaarschmidt, Benedikt (VerfasserIn) , Ludwig, Johannes Maximilian (VerfasserIn) , Fendler, Wolfgang P. (VerfasserIn) , Moraitis, Alexandros (VerfasserIn) , Lahner, Harald (VerfasserIn) , Mathew, Annie (VerfasserIn) , Herrmann, Ken (VerfasserIn) , Weber, Manuel (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 1, 2024
In: Journal of nuclear medicine
Year: 2024, Jahrgang: 65, Heft: 8, Pages: 1175-1180
ISSN:2159-662X
DOI:10.2967/jnumed.124.267774
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2967/jnumed.124.267774
Verlag, lizenzpflichtig, Volltext: http://jnm.snmjournals.org/content/65/8/1175
Volltext
Verfasserangaben:Masao Watanabe, Stephan Leyser, Jens Theysohn, Benedikt Schaarschmidt, Johannes Ludwig, Wolfgang P. Fendler, Alexandros Moraitis, Harald Lahner, Annie Mathew, Ken Herrmann, and Manuel Weber
Beschreibung
Zusammenfassung:The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment response was tested per lesion with a receiver operating characteristic curve analysis, and the association of MAD with progression-free survival (PFS) and overall survival was tested per patient using uni- and multivariate Cox regression analyses. Results: The area under the curve for treatment response based on MAD was 0.79 (cutoff, 196.6 Gy; P < 0.0001). For global PFS, grade (grade 2 vs. 1: hazard ratio [HR], 2.51; P = 0.042; grade 3 vs. 1: HR, 62.44; P < 0.001), tumor origin (HR, 6.58; P < 0.001), and MAD (HR, 0.998; P = 0.003) were significant. For overall survival, no prognostic parameters were significant. Conclusion: In line with prior publications, a MAD of more than 200 Gy seemed to favor treatment response. MAD was also associated with PFS and may be of interest for radioembolization planning for neuroendocrine neoplasm patients.
Beschreibung:Im Titel ist die Zahl 90 bei "90Y Glass Microspheres" hochgestellt
Gesehen am 10.03.2025
Beschreibung:Online Resource
ISSN:2159-662X
DOI:10.2967/jnumed.124.267774

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