Dose-response relationship in patients with liver metastases from neuroendocrine neoplasms undergoing radioembolization with 90Y glass microspheres: brief communication
The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 1, 2024
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| In: |
Journal of nuclear medicine
Year: 2024, Volume: 65, Issue: 8, Pages: 1175-1180 |
| ISSN: | 2159-662X |
| DOI: | 10.2967/jnumed.124.267774 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2967/jnumed.124.267774 Verlag, lizenzpflichtig, Volltext: http://jnm.snmjournals.org/content/65/8/1175 
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| Author Notes: | Masao Watanabe, Stephan Leyser, Jens Theysohn, Benedikt Schaarschmidt, Johannes Ludwig, Wolfgang P. Fendler, Alexandros Moraitis, Harald Lahner, Annie Mathew, Ken Herrmann, and Manuel Weber |
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| 245 | 1 | 0 | |a Dose-response relationship in patients with liver metastases from neuroendocrine neoplasms undergoing radioembolization with 90Y glass microspheres |b brief communication |c Masao Watanabe, Stephan Leyser, Jens Theysohn, Benedikt Schaarschmidt, Johannes Ludwig, Wolfgang P. Fendler, Alexandros Moraitis, Harald Lahner, Annie Mathew, Ken Herrmann, and Manuel Weber |
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| 520 | |a The benefit of multicompartment dosimetry in the radioembolization of neuroendocrine neoplasms is not firmly established. We retrospectively assessed its potential with patient outcome. Methods: Forty-three patients were eligible. The association of mean absorbed dose (MAD) for tumors and treatment response was tested per lesion with a receiver operating characteristic curve analysis, and the association of MAD with progression-free survival (PFS) and overall survival was tested per patient using uni- and multivariate Cox regression analyses. Results: The area under the curve for treatment response based on MAD was 0.79 (cutoff, 196.6 Gy; P < 0.0001). For global PFS, grade (grade 2 vs. 1: hazard ratio [HR], 2.51; P = 0.042; grade 3 vs. 1: HR, 62.44; P < 0.001), tumor origin (HR, 6.58; P < 0.001), and MAD (HR, 0.998; P = 0.003) were significant. For overall survival, no prognostic parameters were significant. Conclusion: In line with prior publications, a MAD of more than 200 Gy seemed to favor treatment response. MAD was also associated with PFS and may be of interest for radioembolization planning for neuroendocrine neoplasm patients. | ||
| 650 | 4 | |a multicompartment dosimetry | |
| 650 | 4 | |a neuroendocrine neoplasm | |
| 650 | 4 | |a radioembolization | |
| 700 | 1 | |a Leyser, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Theysohn, Jens |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaarschmidt, Benedikt |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ludwig, Johannes Maximilian |d 1984- |e VerfasserIn |0 (DE-588)1072015560 |0 (DE-627)826782949 |0 (DE-576)433484144 |4 aut | |
| 700 | 1 | |a Fendler, Wolfgang P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moraitis, Alexandros |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lahner, Harald |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mathew, Annie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herrmann, Ken |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Manuel |e VerfasserIn |4 aut | |
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