Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis
Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multice...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 March 2025
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| In: |
Nature Communications
Year: 2025, Jahrgang: 16, Pages: 1-13 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-025-57144-7 |
| Online-Zugang: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-57144-7 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-57144-7 Resolving-System, kostenfrei, Volltext: https://doi.org/10.25673/119005 
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| Verfasserangaben: | Samir Abu-Rumeileh, Leila Scholle, Alexander Mensch, Henning Großkopf, Antonia Ratti, Anna Kölsch, Gisela Stoltenburg-Didinger, Julian Conrad, Anna De Gobbi, Lorenzo Barba, Petra Steinacker, Hans-Wolfgang Klafki, Patrick Oeckl, Steffen Halbgebauer, Caroline Stapf, Andreas Posa, Thomas Kendzierski, Vincenzo Silani, Lucrezia Hausner, Nicola Ticozzi, Lutz Froelich, Jochen Hans Weishaupt, Federico Verde & Markus Otto |
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| 245 | 1 | 0 | |a Phosphorylated tau 181 and 217 are elevated in serum and muscle of patients with amyotrophic lateral sclerosis |c Samir Abu-Rumeileh, Leila Scholle, Alexander Mensch, Henning Großkopf, Antonia Ratti, Anna Kölsch, Gisela Stoltenburg-Didinger, Julian Conrad, Anna De Gobbi, Lorenzo Barba, Petra Steinacker, Hans-Wolfgang Klafki, Patrick Oeckl, Steffen Halbgebauer, Caroline Stapf, Andreas Posa, Thomas Kendzierski, Vincenzo Silani, Lucrezia Hausner, Nicola Ticozzi, Lutz Froelich, Jochen Hans Weishaupt, Federico Verde & Markus Otto |
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| 520 | |a Blood phosphorylated (p)-tau 181 and p-tau 217 have been proposed as accurate biomarkers of Alzheimer’s disease (AD) pathology. However, blood p-tau 181 is also elevated in amyotrophic lateral sclerosis (ALS) without a clearly identified source. We measured serum p-tau 181 and p-tau 217 in a multicentre cohort of ALS (n = 152), AD (n = 111) cases and disease controls (n = 99) recruited from four different centres. Further, we investigated the existence of both p-tau species using immunohistochemistry (IHC) and mass spectrometry (MS) in muscle biopsies of ALS cases (IHC: n = 13, MS: n = 5) and disease controls (IHC: n = 14, MS: n = 5) from one cohort. Serum p-tau 181 and p-tau 217 were higher in AD and ALS patients compared to disease controls. IHC and MS analyses revealed the presence of p-tau 181 and 217 in muscle biopsies from both ALS cases and disease controls, with ALS samples showing increased p-tau reactivity in atrophic muscle fibres. Blood p-tau species could potentially be used to diagnose both ALS and AD. | ||
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