Another use for a proven drug: experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease
Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer's disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different AD animal models through the reg...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 April 2024
|
| In: |
International journal of molecular sciences
Year: 2024, Volume: 25, Issue: 8, Pages: 1-26 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms25084165 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/ijms25084165
|
| Author Notes: | Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal Venczel Szakács, Joachim Kirsch and Jochen Kuhse |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1919998918 | ||
| 003 | DE-627 | ||
| 005 | 20250717001813.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250318s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms25084165 |2 doi | |
| 035 | |a (DE-627)1919998918 | ||
| 035 | |a (DE-599)KXP1919998918 | ||
| 035 | |a (OCoLC)1528043350 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kiss, Eva |e VerfasserIn |0 (DE-588)1045017329 |0 (DE-627)773423656 |0 (DE-576)398331804 |4 aut | |
| 245 | 1 | 0 | |a Another use for a proven drug |b experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease |c Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal Venczel Szakács, Joachim Kirsch and Jochen Kuhse |
| 264 | 1 | |c 9 April 2024 | |
| 300 | |a 26 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.03.2025 | ||
| 520 | |a Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer's disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different AD animal models through the regulation of a wide range of different cellular processes, such as energy homeostasis, apoptosis, proliferation and inflammatory pathways. In this review, we aimed to provide an up-to-date overview of the experimental evidence documenting the neuroprotective activities of artemi-sinins to underscore the potential of these already-approved drugs for treating AD also in humans and propose their consideration for carefully designed clinical trials. In particular, the benefits to the main pathological hallmarks and events in the pathological cascade throughout AD development in different animal models of AD are summarized. Moreover, dose- and context-dependent effects of artemisinins are noted. | ||
| 650 | 4 | |a Alzheimer Disease | |
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a artemisinins | |
| 650 | 4 | |a Artemisinins | |
| 650 | 4 | |a Disease Models, Animal | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a multitargeting neurotherapeutics | |
| 650 | 4 | |a Neuroprotective Agents | |
| 700 | 1 | |a Kins, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gorgas, Karin |d 1940- |e VerfasserIn |0 (DE-588)106039877X |0 (DE-627)799678171 |0 (DE-576)416486401 |4 aut | |
| 700 | 1 | |a Venczel Szakács, Kinga Hajnal |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kirsch, Joachim |d 1958- |e VerfasserIn |0 (DE-588)103280825X |0 (DE-627)739347020 |0 (DE-576)180113879 |4 aut | |
| 700 | 1 | |a Kuhse, Jochen |e VerfasserIn |0 (DE-588)1171173393 |0 (DE-627)1040413072 |0 (DE-576)513628215 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 25(2024), 8 vom: Apr., Artikel-ID 4165, Seite 1-26 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Another use for a proven drug experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease |
| 773 | 1 | 8 | |g volume:25 |g year:2024 |g number:8 |g month:04 |g elocationid:4165 |g pages:1-26 |g extent:26 |a Another use for a proven drug experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms25084165 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250318 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1171173393 |a Kuhse, Jochen |m 1171173393:Kuhse, Jochen |d 50000 |e 50000PK1171173393 |k 0/50000/ |p 6 |y j | ||
| 998 | |g 103280825X |a Kirsch, Joachim |m 103280825X:Kirsch, Joachim |d 50000 |d 53100 |e 50000PK103280825X |e 53100PK103280825X |k 0/50000/ |k 1/50000/53100/ |p 5 | ||
| 998 | |g 106039877X |a Gorgas, Karin |m 106039877X:Gorgas, Karin |d 50000 |e 50000PG106039877X |k 0/50000/ |p 3 | ||
| 998 | |g 1045017329 |a Kiss, Eva |m 1045017329:Kiss, Eva |d 50000 |e 50000PK1045017329 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1919998918 |e 4687940617 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"part":{"volume":"25","extent":"26","text":"25(2024), 8 vom: Apr., Artikel-ID 4165, Seite 1-26","pages":"1-26","year":"2024","issue":"8"},"origin":[{"dateIssuedDisp":"2000-","publisherPlace":"Basel","publisher":"Molecular Diversity Preservation International","dateIssuedKey":"2000"}],"note":["Gesehen am 17.09.20"],"titleAlt":[{"title":"IJMS"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"International journal of molecular sciences","title":"International journal of molecular sciences"}],"language":["eng"],"disp":"Another use for a proven drug experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's diseaseInternational journal of molecular sciences","id":{"zdb":["2019364-6"],"eki":["316340715"],"issn":["1422-0067","1661-6596"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"316340715","pubHistory":["1.2000 -"]}],"id":{"eki":["1919998918"],"doi":["10.3390/ijms25084165"]},"recId":"1919998918","name":{"displayForm":["Eva Kiss, Stefan Kins, Karin Gorgas, Kinga Hajnal Venczel Szakács, Joachim Kirsch and Jochen Kuhse"]},"physDesc":[{"extent":"26 S."}],"language":["eng"],"note":["Gesehen am 18.03.2025"],"origin":[{"dateIssuedDisp":"9 April 2024","dateIssuedKey":"2024"}],"title":[{"title":"Another use for a proven drug","title_sort":"Another use for a proven drug","subtitle":"experimental evidence for the potential of artemisinin and its derivatives to treat Alzheimer's disease"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","given":"Eva","family":"Kiss","display":"Kiss, Eva"},{"family":"Kins","display":"Kins, Stefan","given":"Stefan","role":"aut"},{"given":"Karin","role":"aut","display":"Gorgas, Karin","family":"Gorgas"},{"given":"Kinga Hajnal","role":"aut","family":"Venczel Szakács","display":"Venczel Szakács, Kinga Hajnal"},{"given":"Joachim","role":"aut","family":"Kirsch","display":"Kirsch, Joachim"},{"given":"Jochen","role":"aut","display":"Kuhse, Jochen","family":"Kuhse"}]} | ||
| SRT | |a KISSEVAKINANOTHERUSE9202 | ||