Treatment of chronic COVID-19 with convalescent/postvaccination plasma in patients with hematologic malignancies
Immunocompromised patients are at high risk to fail clearance of SARS-CoV-2. Prolonged COVID-19 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS-CoV-2 evolves, new variants of concern have emerged that evade available monoclonal antibodies....
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| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
9 May 2024
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| In: |
International journal of cancer
Year: 2024, Volume: 155, Issue: 4, Pages: 618-626 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.34988 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ijc.34988
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| Author Notes: | Maike Janssen, Albrecht Leo, Cornelia Wolf, Miriam Stenzinger, Marie Bartenschlager, Juliane Brandt, Sandra Sauer, Michael Schmitt, Peter Dreger, Richard F. Schlenk, Claudia M. Denkinger, Carsten Müller-Tidow |
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| 245 | 1 | 0 | |a Treatment of chronic COVID-19 with convalescent/postvaccination plasma in patients with hematologic malignancies |c Maike Janssen, Albrecht Leo, Cornelia Wolf, Miriam Stenzinger, Marie Bartenschlager, Juliane Brandt, Sandra Sauer, Michael Schmitt, Peter Dreger, Richard F. Schlenk, Claudia M. Denkinger, Carsten Müller-Tidow |
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| 520 | |a Immunocompromised patients are at high risk to fail clearance of SARS-CoV-2. Prolonged COVID-19 constitutes a health risk and a management problem as cancer treatments often have to be disrupted. As SARS-CoV-2 evolves, new variants of concern have emerged that evade available monoclonal antibodies. Moreover, antiviral therapy promotes SARS-CoV-2 escape mutations, particularly in immunocompromised patients. These patients frequently suffer from prolonged infection. No successful treatment has been established for persistent COVID-19 infection. Here, we report on a series of 21 immunocompromised patients with COVID-19-most of them hematologic malignancies-treated with plasma obtained from recently convalescent or vaccinated donors or a combination thereof. Repeated dosing of SARS-CoV-2-antibody-containing plasma could clear SARS-CoV-2 infection in 16 out of 21 immunocompromised patients even if COVID-19-specific treatments failed to induce sustained viral clearance or to improve clinical course of SARS-CoV-2 infection. Ten patients were major responders defined as an increase delta(d)Ct of > = 5 after the first administration of convalescent and/or vaccinated plasma (C/VP). On average, SARS-CoV-2 PCR Ct values increased from a median value of 22.55 (IQR = 19.10-24.25) to a median value of 29.57 (IQR = 27.55-34.63; p = <.0001) in the major response subgroup. Furthermore, when treated a second time with C/VP, even 4 out of 5 of the initial nonresponders showed an increase in Ct-values from a median value of 23.13 (IQR = 17.75-28.05) to a median value of 32.79 (IQR = 31.75-33.75; p = .013). Our results suggest that C/VP could be a feasible treatment of COVID-19 infection in patients with hematologic malignancies who did not respond to antiviral treatment. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Antibodies, Viral | |
| 650 | 4 | |a Chronic Disease | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a COVID-19 Serotherapy | |
| 650 | 4 | |a COVID-19 Vaccines | |
| 650 | 4 | |a COVID‐19 | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Hematologic Neoplasms | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunization, Passive | |
| 650 | 4 | |a Immunocompromised Host | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a prolonged SARS‐CoV‐2 infection | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a SARS‐CoV‐2‐antibody containing plasma | |
| 650 | 4 | |a Treatment Outcome | |
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