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The prognostic impact of CDKN2A/B hemizygous deletions in IDH-mutant glioma

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Homozygous deletions of CDKN2A/B are known to predict poor prognosis in gliomas, but the impact of hemizygous deletions is less clear. This study aimed to evaluate the prognostic significance of hemizygous CDKN2A/B deletions in IDH-mutant low-grade astrocytomas and oligodendrogliomas.Tissue samples...

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Main Authors: Ippen, Franziska M. (Author) , Hielscher, Thomas (Author) , Friedel, Dennis (Author) , Göbel, Kirsten (Author) , Reuss, David (Author) , Herold-Mende, Christel (Author) , Krieg, Sandro (Author) , Deimling, Andreas von (Author) , Wick, Wolfgang (Author) , Sahm, Felix (Author) , Suwala, Abigail Kora (Author)
Format: Article (Journal)
Language:English
Published: March 2025
In: Neuro-Oncology
Year: 2025, Volume: 27, Issue: 3, Pages: 743-754
ISSN:1523-5866
DOI:10.1093/neuonc/noae238
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/neuonc/noae238
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Author Notes:Franziska M. Ippen, Thomas Hielscher, Dennis Friedel, Kirsten Göbel, David Reuss, Christel Herold-Mende, Sandro Krieg, Andreas v. Deimling, Wolfgang Wick, Felix Sahm, and Abigail K. Suwala
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