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Practical recommendations for therapy and monitoring of mogamulizumab patients in Germany

Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of the heterogeneous group of cutaneous T-cell lymphomas (CTCL). With the expansion of the biologic treatment landscape, new treatment options have become available in recent years, most notably the C-C chemokine receptor...

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Main Authors: Assaf, Chalid (Author) , Booken, Nina (Author) , Dippel, Edgar (Author) , Dobos, Gábor (Author) , Eich, Hans Theodor (Author) , Klemke, Claus-Detlev (Author) , Mitteldorf, Christina (Author) , Nicolay, Jan Peter (Author) , Theurich, Sebastian (Author) , Wobser, Marion (Author) , Stadler, Rudolf (Author)
Format: Article (Journal)
Language:English
Published: March 2025
In: Journal der Deutschen Dermatologischen Gesellschaft
Year: 2025, Volume: 23, Issue: 3, Pages: 341-354
ISSN:1610-0387
DOI:10.1111/ddg.15639
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ddg.15639
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.15639
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Author Notes:Chalid Assaf, Nina Booken, Edgar Dippel, Gabor Dobos, Hans-Theodor Eich, Claus-Detlev Klemke, Christina Mitteldorf, Jan P. Nicolay, Sebastian Theurich, Marion Wobser, Rudolf Stadler
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Summary:Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common subtypes of the heterogeneous group of cutaneous T-cell lymphomas (CTCL). With the expansion of the biologic treatment landscape, new treatment options have become available in recent years, most notably the C-C chemokine receptor 4 (CCR4)-directed monoclonal antibody mogamulizumab. Based on the phase III pivotal trial, mogamulizumab is recommended by the German S2k guidelines for the second-line treatment of stage IB and above SS and MF, after at least one prior systemic therapy. Since then, new insights on safety and efficacy of mogamulizumab were generated by post hoc analyses and real-world evidence. A panel of CTCL-experts discussed available literature and own experiences and developed relevant recommendations on the use of mogamulizumab in clinical practice in Germany. The recommendations cover patient criteria, prior therapies, use of mogamulizumab as monotherapy or combination therapy, management of side effects, duration of therapy, and monitoring schedules. The aim of these clinical recommendations is to support healthcare professionals in their decision-making and use of mogamulizumab in daily practice.
Item Description:Erstmals veröffentlicht: 26. Dezember 2024
Gesehen am 24.03.2025
Physical Description:Online Resource
ISSN:1610-0387
DOI:10.1111/ddg.15639

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