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Modular porous polymer-based microcapsules for trapping and near-infrared light-triggered killing of bacteria via gold nanorods

Due to the increasing occurrence of antibiotic-resistant bacterial strains worldwide, there is an urgent need for developing antibiotic-independent strategies to combat bacterial infections. In this study, we developed a modular approach for trapping, retaining, and killing bacteria by means of poro...

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Main Authors: Conzelmann, Nina (Author) , Benimeli Borràs, Ariadna (Author) , Muduli, Saradaprasan (Author) , Schramm, Anastassiya (Author) , Jeschenko, Pascal Max (Author) , Platzman, Ilia (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: September 23, 2024
In: ACS applied nano materials
Year: 2024, Volume: 7, Issue: 19, Pages: 22650-22661
ISSN:2574-0970
DOI:10.1021/acsanm.4c03636
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1021/acsanm.4c03636
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Author Notes:Nina F. Conzelmann, Ariadna Benimeli Borràs, Saradaprasan Muduli, Anastassiya Schramm, Pascal M. Jeschenko, Ilia Platzman and Joachim P. Spatz
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Summary:Due to the increasing occurrence of antibiotic-resistant bacterial strains worldwide, there is an urgent need for developing antibiotic-independent strategies to combat bacterial infections. In this study, we developed a modular approach for trapping, retaining, and killing bacteria by means of porous, poly(lactic-co-glycolic acid) (PLGA)-based microcapsules with integrated gold nanorods (AuNRs). AuNRs were coated with thiol-functionalized PLGA beforehand to ensure efficient integration into the hydrophobic microcapsule shells. For the efficient generation of AuNR-functionalized microcapsules, we designed and developed a fast and reliable one-pot bulk emulsification production method. When exposing the AuNR-decorated microcapsules to near-infrared light, both motile and nonmotile bacteria were killed in a highly localized manner due to AuNR-generated heat. Importantly, fibroblast cell viability tests performed with AuNR-decorated microcapsules revealed good biocompatibility of the system. Such a modular antibacterial system can be employed in various applications, including, but not limited to, implant coatings, flushing solutions, and sewage treatment.
Item Description:Gesehen am 27.03.2025
Physical Description:Online Resource
ISSN:2574-0970
DOI:10.1021/acsanm.4c03636

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