Digital appendix: Glyco-STORM: lectins as a new labeling tool to decipher the nanoarchitecture of cells
This is the digital appendix to the dissertation with the title "Glyco-STORM: lectins as a new labeling tool to decipher the nanoarchitecture of cells" by Helene Schröter. In this study, previous obstacles in studying the glycome were overcome by combining fluorophore-conjugated lectins -...
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| Dokumenttyp: | Datenbank Forschungsdaten |
| Sprache: | Englisch |
| Veröffentlicht: |
Heidelberg
Universität
2025-03-13
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| DOI: | 10.11588/DATA/Q6YWJ2 |
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| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.11588/DATA/Q6YWJ2 Verlag, lizenzpflichtig, Volltext: https://heidata.uni-heidelberg.de/dataset.xhtml?persistentId=doi:10.11588/DATA/Q6YWJ2 
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| Verfasserangaben: | Helene Schröter |
| Zusammenfassung: | This is the digital appendix to the dissertation with the title "Glyco-STORM: lectins as a new labeling tool to decipher the nanoarchitecture of cells" by Helene Schröter. In this study, previous obstacles in studying the glycome were overcome by combining fluorophore-conjugated lectins - carbohydrate-binding proteins - with super-resolution microscopy. This approach was termed Glyco-STORM and led to the establishment of new anatomical markers to analyse the architecture of cell organelles and synaptic specializations on the nanoscale. Since lectins reflect the carbohydrate-specific morphology of the underlying structures, the results enable a new - ‘glyco-centric’ - picture of cell machineries, achieving a new level in understanding the function of biological systems. Cracking the ‘sugar code’ by using lectins as labels in a biological context could bring a breakthrough in understanding health and disease of organisms. |
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| Beschreibung: | Gesehen am 31.03.2025 |
| Beschreibung: | Online Resource |
| DOI: | 10.11588/DATA/Q6YWJ2 |