Calcium-based imaging of the spine at dual-layer CT and evaluation of vertebral fractures in multiple myeloma
Purpose: To evaluate the prediction of vertebral fractures in plasma cell dyscrasias using dual-layer CT (DLCT) with quantitative assessment of conventional CT image data (CI), calcium suppressed image data (CaSupp), and calculation of virtual calcium-only (VCa) image data. Material and Methods: Pat...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August-1 2024
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| In: |
Cancers
Year: 2024, Jahrgang: 16, Heft: 15 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16152688 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16152688 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/15/2688 
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| Verfasserangaben: | Simone C. Brandelik, Stefanie Rahn, Maximilian Merz, Wolfram Stiller, Stephan Skornitzke, Claudius Melzig, Hans-Ulrich Kauczor, Tim F. Weber and Thuy D. Do |
MARC
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| 245 | 1 | 0 | |a Calcium-based imaging of the spine at dual-layer CT and evaluation of vertebral fractures in multiple myeloma |c Simone C. Brandelik, Stefanie Rahn, Maximilian Merz, Wolfram Stiller, Stephan Skornitzke, Claudius Melzig, Hans-Ulrich Kauczor, Tim F. Weber and Thuy D. Do |
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| 520 | |a Purpose: To evaluate the prediction of vertebral fractures in plasma cell dyscrasias using dual-layer CT (DLCT) with quantitative assessment of conventional CT image data (CI), calcium suppressed image data (CaSupp), and calculation of virtual calcium-only (VCa) image data. Material and Methods: Patients (n = 81) with the diagnosis of a plasma cell dyscrasia and whole-body DLCT at the time of diagnosis and follow-up were retrospectively enrolled. CI, CaSupp25, and CaSupp100 were quantitatively analyzed using regions of interest in the lumbar vertebral bodies and fractured vertebral bodies on baseline or follow-up imaging. VCa were calculated by subtraction (CaSupp100-CaSupp25), delineating bone only. Logistic regression analyses were performed to assess the possibility of imminent spine fractures. Results: In 24 patients, new vertebral fractures were observed in the follow-up imaging. The possibility of new vertebral fractures was significant for baseline assessment of CT numbers in CI, CaSupp25, and VCa (p = 0.01, respectively), with a higher risk for new fractures in the case of lower CT numbers in CI (Odds ratio = [0.969; 0.994]) and VCa (Odds ratio = [0.978; 0.995]) and in the case of higher CT numbers in CaSupp 25 (Odds ratio 1.015 [1.006; 1.026]). Direct model comparisons implied that CT numbers in CaSupp 25 and VCa might show better fracture prediction than those in CI (R2 = 0.18 both vs. 0.15; AICc = 91.95, 91.79 vs. 93.62), suggesting cut-off values for CI at 103 HU (sensitivity: 54.2%; specificity: 82.5; AUC: 0.69), for VCa at 129 HU (sensitivity: 41.7%; specificity: 94.7; AUC: 0.72). Conclusions: Quantitative assessment with CaSupp and calculation of VCa is feasible to predict the vertebral fracture risk in MM patients. DLCT may prove useful in detecting imminent fractures. | ||
| 650 | 4 | |a computed tomography | |
| 650 | 4 | |a dual-layer spectral CT | |
| 650 | 4 | |a fractures | |
| 650 | 4 | |a multiple myeloma | |
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