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CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma: brief communication

Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) were shown to be an active and pivotal cell population, supporting many protumorigenic mechanisms. Podoplanin (PDPN)-positive CAFs are of special interest since their abundance correlated with a worse prognosis for patient...

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Main Authors: Tauch, Saskia (Author) , Kast, Bettina (Author) , Lohr, Sabrina (Author) , Kemm, Lowis (Author) , Sator-Schmitt, Melanie (Author) , Gengenbacher, Nicolas (Author) , Augustin, Hellmut (Author) , Angel, Peter (Author)
Format: Article (Journal)
Language:English
Published: February 2025
In: Molecular carcinogenesis
Year: 2025, Volume: 64, Issue: 2, Pages: 215-220
ISSN:1098-2744
DOI:10.1002/mc.23841
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/mc.23841
Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23841
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Author Notes:Saskia Tauch, Bettina Kast, Sabrina Lohr, Lowis Kemm, Melanie Sator-Schmitt, Nicolas Gengenbacher, Hellmut G. Augustin, Peter Angel
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Summary:Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) were shown to be an active and pivotal cell population, supporting many protumorigenic mechanisms. Podoplanin (PDPN)-positive CAFs are of special interest since their abundance correlated with a worse prognosis for patients of different cancer entities, including malignant melanoma. In this study, we applied a loss-of-function approach in an in vivo mouse melanoma model to evaluate the contribution of CAF-specific PDPN expression to melanoma formation and progression. Surprisingly, despite its prominent expression in CAFs deletion of PDPN in this cell type did neither affect the onset, nor growth of MM tumors. These data imply that PDPN expression in CAFs represents a biomarker for poor prognosis but does not serve as a useful target for stroma-directed therapy of malignant melanoma.
Item Description:Erstmals veröffentlicht: 08. November 2024
Gesehen am 01.04.2025
Physical Description:Online Resource
ISSN:1098-2744
DOI:10.1002/mc.23841

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