CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma: brief communication
Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) were shown to be an active and pivotal cell population, supporting many protumorigenic mechanisms. Podoplanin (PDPN)-positive CAFs are of special interest since their abundance correlated with a worse prognosis for patient...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
February 2025
|
| In: |
Molecular carcinogenesis
Year: 2025, Volume: 64, Issue: 2, Pages: 215-220 |
| ISSN: | 1098-2744 |
| DOI: | 10.1002/mc.23841 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/mc.23841 Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23841 
|
| Author Notes: | Saskia Tauch, Bettina Kast, Sabrina Lohr, Lowis Kemm, Melanie Sator-Schmitt, Nicolas Gengenbacher, Hellmut G. Augustin, Peter Angel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 192090218X | ||
| 003 | DE-627 | ||
| 005 | 20250717004013.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250401s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/mc.23841 |2 doi | |
| 035 | |a (DE-627)192090218X | ||
| 035 | |a (DE-599)KXP192090218X | ||
| 035 | |a (OCoLC)1528044071 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Tauch, Saskia |d 1995- |e VerfasserIn |0 (DE-588)1296836606 |0 (DE-627)1853246816 |4 aut | |
| 245 | 1 | 0 | |a CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma |b brief communication |c Saskia Tauch, Bettina Kast, Sabrina Lohr, Lowis Kemm, Melanie Sator-Schmitt, Nicolas Gengenbacher, Hellmut G. Augustin, Peter Angel |
| 264 | 1 | |c February 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Erstmals veröffentlicht: 08. November 2024 | ||
| 500 | |a Gesehen am 01.04.2025 | ||
| 520 | |a Within the tumor microenvironment (TME), cancer-associated fibroblasts (CAFs) were shown to be an active and pivotal cell population, supporting many protumorigenic mechanisms. Podoplanin (PDPN)-positive CAFs are of special interest since their abundance correlated with a worse prognosis for patients of different cancer entities, including malignant melanoma. In this study, we applied a loss-of-function approach in an in vivo mouse melanoma model to evaluate the contribution of CAF-specific PDPN expression to melanoma formation and progression. Surprisingly, despite its prominent expression in CAFs deletion of PDPN in this cell type did neither affect the onset, nor growth of MM tumors. These data imply that PDPN expression in CAFs represents a biomarker for poor prognosis but does not serve as a useful target for stroma-directed therapy of malignant melanoma. | ||
| 650 | 4 | |a CAF | |
| 650 | 4 | |a GEMM model | |
| 650 | 4 | |a melanoma | |
| 650 | 4 | |a podoplanin | |
| 650 | 4 | |a TME | |
| 700 | 1 | |a Kast, Bettina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lohr, Sabrina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kemm, Lowis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sator-Schmitt, Melanie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gengenbacher, Nicolas |d 1986- |e VerfasserIn |0 (DE-588)1159735816 |0 (DE-627)1022418254 |0 (DE-576)505272857 |4 aut | |
| 700 | 1 | |a Augustin, Hellmut |d 1959- |e VerfasserIn |0 (DE-588)102307737X |0 (DE-627)717361470 |0 (DE-576)171124766 |4 aut | |
| 700 | 1 | |a Angel, Peter |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Molecular carcinogenesis |d New York, NY : Wiley Interscience, 1988 |g 64(2025), 2 vom: Feb., Seite 215-220 |h Online-Ressource |w (DE-627)320416364 |w (DE-600)2001984-1 |w (DE-576)11461752X |x 1098-2744 |7 nnas |a CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma brief communication |
| 773 | 1 | 8 | |g volume:64 |g year:2025 |g number:2 |g month:02 |g pages:215-220 |g extent:6 |a CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma brief communication |
| 856 | 4 | 0 | |u https://doi.org/10.1002/mc.23841 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://onlinelibrary.wiley.com/doi/abs/10.1002/mc.23841 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250401 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 102307737X |a Augustin, Hellmut |m 102307737X:Augustin, Hellmut |d 60000 |d 65000 |e 60000PA102307737X |e 65000PA102307737X |k 0/60000/ |k 1/60000/65000/ |p 7 | ||
| 998 | |g 1159735816 |a Gengenbacher, Nicolas |m 1159735816:Gengenbacher, Nicolas |p 6 | ||
| 999 | |a KXP-PPN192090218X |e 4695800551 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Erstmals veröffentlicht: 08. November 2024","Gesehen am 01.04.2025"],"recId":"192090218X","language":["eng"],"person":[{"given":"Saskia","family":"Tauch","role":"aut","roleDisplay":"VerfasserIn","display":"Tauch, Saskia"},{"display":"Kast, Bettina","roleDisplay":"VerfasserIn","role":"aut","family":"Kast","given":"Bettina"},{"role":"aut","display":"Lohr, Sabrina","roleDisplay":"VerfasserIn","given":"Sabrina","family":"Lohr"},{"display":"Kemm, Lowis","roleDisplay":"VerfasserIn","role":"aut","family":"Kemm","given":"Lowis"},{"family":"Sator-Schmitt","given":"Melanie","display":"Sator-Schmitt, Melanie","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Gengenbacher","given":"Nicolas","display":"Gengenbacher, Nicolas","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Augustin, Hellmut","role":"aut","family":"Augustin","given":"Hellmut"},{"role":"aut","display":"Angel, Peter","roleDisplay":"VerfasserIn","given":"Peter","family":"Angel"}],"title":[{"title_sort":"CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma","subtitle":"brief communication","title":"CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma"}],"physDesc":[{"noteIll":"Illustrationen","extent":"6 S."}],"relHost":[{"id":{"zdb":["2001984-1"],"doi":["10.1002/(ISSN)1098-2744"],"eki":["320416364"],"issn":["1098-2744"]},"origin":[{"publisherPlace":"New York, NY","publisher":"Wiley Interscience","dateIssuedKey":"1988","dateIssuedDisp":"1988-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Molecular carcinogenesis","title_sort":"Molecular carcinogenesis"}],"part":{"extent":"6","volume":"64","text":"64(2025), 2 vom: Feb., Seite 215-220","issue":"2","pages":"215-220","year":"2025"},"pubHistory":["1.1988 -"],"recId":"320416364","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 27.02.08"],"disp":"CAF specific expression of podoplanin may be dispensable for the malignancy of malignant melanoma brief communicationMolecular carcinogenesis"}],"name":{"displayForm":["Saskia Tauch, Bettina Kast, Sabrina Lohr, Lowis Kemm, Melanie Sator-Schmitt, Nicolas Gengenbacher, Hellmut G. Augustin, Peter Angel"]},"origin":[{"dateIssuedDisp":"February 2025","dateIssuedKey":"2025"}],"id":{"eki":["192090218X"],"doi":["10.1002/mc.23841"]}} | ||
| SRT | |a TAUCHSASKICAFSPECIFI2025 | ||