Regional adoptive immunotherapy with interleukin-2 and lymphokine-activated killer (LAK) cells for liver metastases
A phase lb trial of a novel regional approach to adoptive immunotherapy is reported. Patients with liver metastases received continuous high-dose infusion of interleukin-2 (IL-2) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine-activated killer (LAK) cells into...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1994
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| In: |
European journal of cancer
Year: 1994, Jahrgang: 30, Heft: 1, Pages: 103-105 |
| ISSN: | 1879-0852 |
| DOI: | 10.1016/S0959-8049(05)80028-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0959-8049(05)80028-0 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804905800280 
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| Verfasserangaben: | Ulrich Keilholz, Carmen Scheibenbogen, Mathias Brado, Peter Georgi, David Maclachlan, Bernadett Brado and Werner Hunstein |
MARC
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| 245 | 1 | 0 | |a Regional adoptive immunotherapy with interleukin-2 and lymphokine-activated killer (LAK) cells for liver metastases |c Ulrich Keilholz, Carmen Scheibenbogen, Mathias Brado, Peter Georgi, David Maclachlan, Bernadett Brado and Werner Hunstein |
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| 520 | |a A phase lb trial of a novel regional approach to adoptive immunotherapy is reported. Patients with liver metastases received continuous high-dose infusion of interleukin-2 (IL-2) into the splenic artery or intravenous infusion with subsequent transfer of lymphokine-activated killer (LAK) cells into the portal vein or the hepatic artery. Trafficking studies revealed homogenous distribution of the LAK cells within the liver. The usual side-effects of IL-2 and LAK cells occurred without limiting liver toxicity. One partial (7+ months) and two complete responses (36 and 26+ months) were observed in 9 patients with metastases from cutaneous melanoma. None of 6 patients with metastases from ocular melanoma responded. | ||
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