H-1 parvovirus-induced oncolysis and tumor microenvironment immune modulation in a novel heterotypic spheroid model of cutaneous T-cell lymphoma
The rat protoparvovirus H-1 (H-1PV) is an oncolytic virus known for its anticancer properties in laboratory models of various human tumors, including non-Hodgkin lymphomas (NHL) of B-cell origin. However, H-1PV therapeutic potential against hematological malignancies of T-cell origin remains underex...
Gespeichert in:
| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August-1 2024
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| In: |
Cancers
Year: 2024, Jahrgang: 16, Heft: 15, Pages: 1-21 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16152711 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16152711 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/15/2711 
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| Verfasserangaben: | Assia Angelova, Milena Barf, Alexandra Just, Barbara Leuchs, Jean Rommelaere and Guy Ungerechts |
MARC
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| 245 | 1 | 0 | |a H-1 parvovirus-induced oncolysis and tumor microenvironment immune modulation in a novel heterotypic spheroid model of cutaneous T-cell lymphoma |c Assia Angelova, Milena Barf, Alexandra Just, Barbara Leuchs, Jean Rommelaere and Guy Ungerechts |
| 246 | 1 | |i Titel des special issue |a Oncolytic viruses as an emerging aspect of immune oncology | |
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| 520 | |a The rat protoparvovirus H-1 (H-1PV) is an oncolytic virus known for its anticancer properties in laboratory models of various human tumors, including non-Hodgkin lymphomas (NHL) of B-cell origin. However, H-1PV therapeutic potential against hematological malignancies of T-cell origin remains underexplored. The aim of the present study was to conduct a pilot preclinical investigation of H-1PV-mediated oncolytic effects in cutaneous T-cell lymphoma (CTCL), a type of NHL that is urgently calling for innovative therapies. We demonstrated H-1PV productive infection and induction of oncolysis in both classically grown CTCL suspension cultures and in a novel, in vivo-relevant, heterotypic spheroid model, but not in healthy donor controls, including peripheral blood mononuclear cells (PBMCs). H-1PV-mediated oncolysis of CTCL cells was not prevented by Bcl-2 overexpression and was accompanied by increased extracellular ATP release. In CTCL spheroid co-cultures with PBMCs, increased spheroid infiltration with immune cells was detected upon co-culture treatment with the virus. In conclusion, our preclinical data show that H-1PV may hold significant potential as an ingenious viroimmunotherapeutic drug candidate against CTCL. | ||
| 650 | 4 | |a cutaneous T-cell lymphoma (CTCL) | |
| 650 | 4 | |a heterotypic CTCL spheroid | |
| 650 | 4 | |a oncolytic H-1 parvovirus | |
| 650 | 4 | |a virotherapy | |
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| 700 | 1 | |a Just, Alexandra |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Ungerechts, Guy |d 1972- |e VerfasserIn |0 (DE-588)124557902 |0 (DE-627)363420053 |0 (DE-576)294230939 |4 aut | |
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