Buchumschlag

Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION): Study protocol of a phase III trial

Rationale: Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question. - Aims: The REperfusion therapy with intravenous al...

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Hauptverfasser: Poli, Sven (VerfasserIn) , Grohmann, Carsten (VerfasserIn) , Wenzel, Daniel A. (VerfasserIn) , Poli, Khouloud (VerfasserIn) , Tünnerhoff, Johannes (VerfasserIn) , Nedelmann, Max (VerfasserIn) , Fiehler, Jens (VerfasserIn) , Burghaus, Ina (VerfasserIn) , Lehmann, Monika (VerfasserIn) , Glauch, Monika (VerfasserIn) , Schadwinkel, Hauke M. (VerfasserIn) , Kalmbach, Pia (VerfasserIn) , Zeller, Julia (VerfasserIn) , Peters, Tobias (VerfasserIn) , Eschenfelder, Christoph C. (VerfasserIn) , Agostini, Hansjürgen (VerfasserIn) , Campbell, Bruce CV (VerfasserIn) , Fischer, M. Dominik (VerfasserIn) , Sykora, Marek (VerfasserIn) , Mac Grory, Brian (VerfasserIn) , Feltgen, Nicolas (VerfasserIn) , Kowarik, Markus (VerfasserIn) , Seiffge, David (VerfasserIn) , Strbian, Daniel (VerfasserIn) , Albrecht, Michael (VerfasserIn) , Alzureiqi, Mohammad S. (VerfasserIn) , Auffarth, Gerd U. (VerfasserIn) , Bäzner, Hansjörg (VerfasserIn) , Behnke, Stefanie (VerfasserIn) , Berberich, Anne (VerfasserIn) , Bode, Felix J. (VerfasserIn) , Bohmann, Ferdinand O. (VerfasserIn) , Cheng, Bastian (VerfasserIn) , Czihal, Michael (VerfasserIn) , Danyel, Leon A. (VerfasserIn) , Dimopoulos, Spyridon (VerfasserIn) , Pinhal Ferreira de Pinho, João D. (VerfasserIn) , Fries, Fabian N. (VerfasserIn) , Gamulescu, Maria-Andreea (VerfasserIn) , Gekeler, Florian (VerfasserIn) , Gomez-Exposito, Alexandra (VerfasserIn) , Gumbinger, Christoph (VerfasserIn) , Guthoff, Rainer (VerfasserIn) , Hattenbach, Lars-Olof (VerfasserIn) , Kellert, Lars (VerfasserIn) , Khoramnia, Ramin (VerfasserIn) , Kohnen, Thomas (VerfasserIn) , Kürten, David (VerfasserIn) , Lackner, Bernhard (VerfasserIn) , Laible, Mona (VerfasserIn) , Lee, John-Ih (VerfasserIn) , Leithner, Christoph (VerfasserIn) , Liegl, Raffael (VerfasserIn) , Lochner, Piergiorgio (VerfasserIn) , Mackert, Marc (VerfasserIn) , Mbroh, Joshua (VerfasserIn) , Müller, Susanne (VerfasserIn) , Nagel, Simon (VerfasserIn) , Prasuhn, Michelle (VerfasserIn) , Purrucker, Jan (VerfasserIn) , Reich, Arno (VerfasserIn) , Mundiyanapurath, Sibu (VerfasserIn) , Royl, Georg (VerfasserIn) , Salchow, Daniel J. (VerfasserIn) , Schäfer, Jan H. (VerfasserIn) , Schlachetzki, Felix (VerfasserIn) , Schmack, Ingo (VerfasserIn) , Thomalla, Götz (VerfasserIn) , Tieck Fernandez, Maria P. (VerfasserIn) , Wakili, Philip (VerfasserIn) , Walter, Peter (VerfasserIn) , Wolf, Armin (VerfasserIn) , Wolf, Marc (VerfasserIn) , Bartz-Schmidt, Karl U. (VerfasserIn) , Schultheiß, Maximilian (VerfasserIn) , Spitzer, Martin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 9, 2024
In: International journal of stroke
Year: 2024, Jahrgang: 19, Heft: 7, Pages: 823-829
ISSN:1747-4949
DOI:10.1177/17474930241248516
Online-Zugang:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1177/17474930241248516
Verlag, kostenfrei, Volltext: https://journals.sagepub.com/doi/10.1177/17474930241248516
Volltext
Verfasserangaben:Sven Poli, Carsten Grohmann, Daniel A Wenzel, Khouloud Poli, Johannes Tünnerhoff, Max Nedelmann, Jens Fiehler, Ina Burghaus, Monika Lehmann, Monika Glauch, Hauke M Schadwinkel, Pia Kalmbach, Julia Zeller, Tobias Peters, Christoph Eschenfelder, Hansjürgen Agostini, Bruce CV Campbell, M Dominik Fischer, Marek Sykora, Brian Mac Grory, Nicolas Feltgen, Markus Kowarik, David Seiffge, Daniel Strbian, Michael Albrecht, Mohammad S Alzureiqi, Gerd Auffarth, Hansjörg Bäzner, Stefanie Behnke, Anne Berberich, Felix Bode, Ferdinand O Bohmann, Bastian Cheng, Michael Czihal, Leon A. Danyel, Spyridon Dimopoulos, João D Pinhal Ferreira de Pinho, Fabian N Fries, Maria-Andreea Gamulescu, Florian Gekeler, Alexandra Gomez-Exposito, Christoph Gumbinger, Rainer Guthoff, Lars-Olof Hattenbach, Lars Kellert, Ramin Khoramnia, Thomas Kohnen, David Kürten, Bernhard Lackner, Mona Laible, John-Ih Lee, Christoph Leithner, Raffael Liegl, Piergiorgio Lochner, Marc Mackert, Joshua Mbroh, Susanne Müller, Simon Nagel, Michelle Prasuhn, Jan Purrucker, Arno Reich, Sibu Mundiyanapurath, Georg Royl, Daniel J Salchow, Jan H Schäfer, Felix Schlachetzki, Ingo Schmack, Götz Thomalla, Maria P Tieck Fernandez, Philip Wakili, Peter Walter, Armin Wolf, Marc Wolf, Karl U Bartz-Schmidt, Maximilian Schultheiss, and Martin S Spitzer, on behalf of the REVISION investigators

MARC

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245 1 0 |a Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION)  |b Study protocol of a phase III trial  |c Sven Poli, Carsten Grohmann, Daniel A Wenzel, Khouloud Poli, Johannes Tünnerhoff, Max Nedelmann, Jens Fiehler, Ina Burghaus, Monika Lehmann, Monika Glauch, Hauke M Schadwinkel, Pia Kalmbach, Julia Zeller, Tobias Peters, Christoph Eschenfelder, Hansjürgen Agostini, Bruce CV Campbell, M Dominik Fischer, Marek Sykora, Brian Mac Grory, Nicolas Feltgen, Markus Kowarik, David Seiffge, Daniel Strbian, Michael Albrecht, Mohammad S Alzureiqi, Gerd Auffarth, Hansjörg Bäzner, Stefanie Behnke, Anne Berberich, Felix Bode, Ferdinand O Bohmann, Bastian Cheng, Michael Czihal, Leon A. Danyel, Spyridon Dimopoulos, João D Pinhal Ferreira de Pinho, Fabian N Fries, Maria-Andreea Gamulescu, Florian Gekeler, Alexandra Gomez-Exposito, Christoph Gumbinger, Rainer Guthoff, Lars-Olof Hattenbach, Lars Kellert, Ramin Khoramnia, Thomas Kohnen, David Kürten, Bernhard Lackner, Mona Laible, John-Ih Lee, Christoph Leithner, Raffael Liegl, Piergiorgio Lochner, Marc Mackert, Joshua Mbroh, Susanne Müller, Simon Nagel, Michelle Prasuhn, Jan Purrucker, Arno Reich, Sibu Mundiyanapurath, Georg Royl, Daniel J Salchow, Jan H Schäfer, Felix Schlachetzki, Ingo Schmack, Götz Thomalla, Maria P Tieck Fernandez, Philip Wakili, Peter Walter, Armin Wolf, Marc Wolf, Karl U Bartz-Schmidt, Maximilian Schultheiss, and Martin S Spitzer, on behalf of the REVISION investigators 
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520 |a Rationale: Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data are lacking to address this question. - Aims: The REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION) investigates intravenous alteplase within 4.5 h of monocular vision loss due to acute CRAO. - Methods: This study is the randomized (1:1), double-blind, placebo-controlled, multicenter adaptive phase III trial. - Study outcomes: Primary outcome is functional recovery to normal or mildly impaired vision in the affected eye defined as best-corrected visual acuity of the Logarithm of the Minimum Angle of Resolution of 0.5 or less at 30 days (intention-to-treat analysis). Secondary efficacy outcomes include modified Rankin Score at 90 days and quality of life. Safety outcomes include symptomatic intracranial hemorrhage, major bleeding (International Society on Thrombosis and Haemostasis definition) and mortality. Exploratory analyses of optical coherence tomography/angiography, ultrasound and magnetic resonance imaging (MRI) biomarkers will be conducted. - Sample size: Using an adaptive design with interim analysis at 120 patients, up to 422 participants (211 per arm) would be needed for 80% power (one-sided alpha = 0.025) to detect a difference of 15%, assuming functional recovery rates of 10% in the placebo arm and 25% in the alteplase arm. - Discussion: By enrolling patients within 4.5 h of CRAO onset, REVISION uses insights from meta-analyses of CRAO case series and randomized thrombolysis trials in acute ischemic stroke. Increased rates of early reperfusion and good neurological outcomes in stroke may translate to CRAO with its similar pathophysiology. - Trial registration: ClinicalTrials.gov: NCT04965038; EU Trial Number: 2023-507388-21-00. 
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JSO |a {"note":["Gesehen am 07.04.2025"],"language":["eng"],"physDesc":[{"extent":"7 S."}],"recId":"1921722495","relHost":[{"note":["Gesehen am 10.02.2021"],"recId":"503720291","physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"official journal of the International Stroke Society"}],"pubHistory":["Volume 1, issue 1 (February 2006)-"],"language":["eng"],"disp":"Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION) Study protocol of a phase III trialInternational journal of stroke","title":[{"title":"International journal of stroke","title_sort":"International journal of stroke","subtitle":"official journal of the World Stroke Organization"}],"origin":[{"publisher":"Sage ; Blackwell ; Wiley-Blackwell","publisherPlace":"London ; Oxford [u.a.] ; Oxford [u.a.]","dateIssuedDisp":"21 November 2005-"}],"id":{"issn":["1747-4949"],"eki":["503720291"],"zdb":["2211666-7"],"doi":["10.1111/(ISSN)1747-4949"]},"part":{"pages":"823-829","year":"2024","text":"19(2024), 7 vom: Aug., Seite 823-829","extent":"7","volume":"19","issue":"7"}}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION)","title":"Early REperfusion therapy with intravenous alteplase for recovery of VISION in acute central retinal artery occlusion (REVISION)","subtitle":"Study protocol of a phase III trial"}],"name":{"displayForm":["Sven Poli, Carsten Grohmann, Daniel A Wenzel, Khouloud Poli, Johannes Tünnerhoff, Max Nedelmann, Jens Fiehler, Ina Burghaus, Monika Lehmann, Monika Glauch, Hauke M Schadwinkel, Pia Kalmbach, Julia Zeller, Tobias Peters, Christoph Eschenfelder, Hansjürgen Agostini, Bruce CV Campbell, M Dominik Fischer, Marek Sykora, Brian Mac Grory, Nicolas Feltgen, Markus Kowarik, David Seiffge, Daniel Strbian, Michael Albrecht, Mohammad S Alzureiqi, Gerd Auffarth, Hansjörg Bäzner, Stefanie Behnke, Anne Berberich, Felix Bode, Ferdinand O Bohmann, Bastian Cheng, Michael Czihal, Leon A. Danyel, Spyridon Dimopoulos, João D Pinhal Ferreira de Pinho, Fabian N Fries, Maria-Andreea Gamulescu, Florian Gekeler, Alexandra Gomez-Exposito, Christoph Gumbinger, Rainer Guthoff, Lars-Olof Hattenbach, Lars Kellert, Ramin Khoramnia, Thomas Kohnen, David Kürten, Bernhard Lackner, Mona Laible, John-Ih Lee, Christoph Leithner, Raffael Liegl, Piergiorgio Lochner, Marc Mackert, Joshua Mbroh, Susanne Müller, Simon Nagel, Michelle Prasuhn, Jan Purrucker, Arno Reich, Sibu Mundiyanapurath, Georg Royl, Daniel J Salchow, Jan H Schäfer, Felix Schlachetzki, Ingo Schmack, Götz Thomalla, Maria P Tieck Fernandez, Philip Wakili, Peter Walter, Armin Wolf, Marc Wolf, Karl U Bartz-Schmidt, Maximilian Schultheiss, and Martin S Spitzer, on behalf of the REVISION investigators"]},"origin":[{"dateIssuedDisp":"April 9, 2024","dateIssuedKey":"2024"}],"person":[{"role":"aut","display":"Poli, Sven","family":"Poli","given":"Sven"},{"given":"Carsten","family":"Grohmann","role":"aut","display":"Grohmann, Carsten"},{"family":"Wenzel","display":"Wenzel, Daniel A.","role":"aut","given":"Daniel A."},{"given":"Khouloud","family":"Poli","display":"Poli, Khouloud","role":"aut"},{"given":"Johannes","role":"aut","display":"Tünnerhoff, Johannes","family":"Tünnerhoff"},{"role":"aut","display":"Nedelmann, Max","family":"Nedelmann","given":"Max"},{"role":"aut","display":"Fiehler, Jens","family":"Fiehler","given":"Jens"},{"given":"Ina","family":"Burghaus","role":"aut","display":"Burghaus, Ina"},{"given":"Monika","family":"Lehmann","display":"Lehmann, Monika","role":"aut"},{"display":"Glauch, Monika","role":"aut","family":"Glauch","given":"Monika"},{"role":"aut","display":"Schadwinkel, Hauke M.","family":"Schadwinkel","given":"Hauke M."},{"given":"Pia","display":"Kalmbach, Pia","role":"aut","family":"Kalmbach"},{"given":"Julia","family":"Zeller","display":"Zeller, Julia","role":"aut"},{"role":"aut","display":"Peters, Tobias","family":"Peters","given":"Tobias"},{"family":"Eschenfelder","display":"Eschenfelder, Christoph C.","role":"aut","given":"Christoph C."},{"given":"Hansjürgen","family":"Agostini","role":"aut","display":"Agostini, Hansjürgen"},{"given":"Bruce CV","role":"aut","display":"Campbell, Bruce CV","family":"Campbell"},{"given":"M. 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SRT |a POLISVENGREARLYREPER9202 

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