Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction
Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
05 December 2024
|
| In: |
Translational Psychiatry
Year: 2024, Jahrgang: 14, Pages: 1-10 |
| ISSN: | 2158-3188 |
| DOI: | 10.1038/s41398-024-03189-z |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41398-024-03189-z Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41398-024-03189-z 
|
| Verfasserangaben: | Bettina Habelt, Dzmitry Afanasenkau, Cindy Schwarz, Kevin Domanegg, Martin Kuchar, Carsten Werner, Ivan R. Minev, Rainer Spanagel, Marcus W. Meinhardt and Nadine Bernhardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1921885351 | ||
| 003 | DE-627 | ||
| 005 | 20250717005247.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250408s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41398-024-03189-z |2 doi | |
| 035 | |a (DE-627)1921885351 | ||
| 035 | |a (DE-599)KXP1921885351 | ||
| 035 | |a (OCoLC)1528044292 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Habelt, Bettina |e VerfasserIn |0 (DE-588)1362709131 |0 (DE-627)192188584X |4 aut | |
| 245 | 1 | 0 | |a Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction |c Bettina Habelt, Dzmitry Afanasenkau, Cindy Schwarz, Kevin Domanegg, Martin Kuchar, Carsten Werner, Ivan R. Minev, Rainer Spanagel, Marcus W. Meinhardt and Nadine Bernhardt |
| 264 | 1 | |c 05 December 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.04.2025 | ||
| 520 | |a Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in AUD. This results in reduced inhibitory control of compulsive behavior and, eventually, relapse. We reasoned here that prefrontal dysfunction, which underlies vulnerability to relapse, is evidenced by altered neuroelectric signatures and should be restored by pharmacological interventions that specifically target prefrontal dysfunction. To test this, we applied our recently developed biocompatible neuroprosthesis to measure prefrontal neural function in a well-established rat model of alcohol addiction and relapse. We monitored neural oscillations and event-related potentials in awake alcohol-dependent rats during abstinence and following treatment with psilocybin or LY379268, agonists of the serotonin 2A receptor (5-HT2AR), and the metabotropic glutamate receptor 2 (mGluR2), that are known to reduce prefrontal dysfunction and relapse. Electrophysiological impairments in alcohol-dependent rats are reduced amplitudes of P1N1 and N1P2 components and attenuated event-related oscillatory activity. Psilocybin and LY379268 were able to restore these impairments. Furthermore, alcohol-dependent animals displayed a dominance in higher beta frequencies indicative of a state of hyperarousal that is prone to relapse, which particularly psilocybin was able to counteract. In summary, we provide prefrontal markers indicative of relapse and treatment response, especially for psychedelic drugs. | ||
| 650 | 4 | |a Biomarkers | |
| 650 | 4 | |a Neuroscience | |
| 700 | 1 | |a Afanasenkau, Dzmitry |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwarz, Cindy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Domanegg, Kevin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuchar, Martin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Werner, Carsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Minev, Ivan R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Spanagel, Rainer |d 1961- |e VerfasserIn |0 (DE-588)112706312 |0 (DE-627)521941261 |0 (DE-576)289740002 |4 aut | |
| 700 | 1 | |a Meinhardt, Marcus W. |e VerfasserIn |0 (DE-588)105790189X |0 (DE-627)795388179 |0 (DE-576)41390749X |4 aut | |
| 700 | 1 | |8 1\p |a Bernhardt, Nadine |d 1978- |e VerfasserIn |0 (DE-588)1237711479 |0 (DE-627)1764651898 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Translational Psychiatry |d London : Nature Publishing Group, 2011 |g 14(2024), Artikel-ID 486, Seite 1-10 |h Online-Ressource |w (DE-627)660807378 |w (DE-600)2609311-X |w (DE-576)345003462 |x 2158-3188 |7 nnas |a Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction |
| 773 | 1 | 8 | |g volume:14 |g year:2024 |g elocationid:486 |g pages:1-10 |g extent:10 |a Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41398-024-03189-z |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.nature.com/articles/s41398-024-03189-z |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250505 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250408 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 112706312 |a Spanagel, Rainer |m 112706312:Spanagel, Rainer |d 60000 |e 60000PS112706312 |k 0/60000/ |p 8 | ||
| 999 | |a KXP-PPN1921885351 |e 4698198941 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"05 December 2024","dateIssuedKey":"2024"}],"recId":"1921885351","type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["660807378"],"issn":["2158-3188"],"zdb":["2609311-X"]},"disp":"Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addictionTranslational Psychiatry","note":["Gesehen am 17.05.11"],"origin":[{"dateIssuedKey":"2011","dateIssuedDisp":"2011-","publisher":"Nature Publishing Group","publisherPlace":"London"}],"recId":"660807378","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title_sort":"Translational Psychiatry","title":"Translational Psychiatry"}],"part":{"extent":"10","pages":"1-10","text":"14(2024), Artikel-ID 486, Seite 1-10","year":"2024","volume":"14"},"language":["eng"],"pubHistory":["1.2011 -"]}],"note":["Gesehen am 08.04.2025"],"id":{"doi":["10.1038/s41398-024-03189-z"],"eki":["1921885351"]},"physDesc":[{"extent":"10 S.","noteIll":"Illustrationen"}],"name":{"displayForm":["Bettina Habelt, Dzmitry Afanasenkau, Cindy Schwarz, Kevin Domanegg, Martin Kuchar, Carsten Werner, Ivan R. Minev, Rainer Spanagel, Marcus W. Meinhardt and Nadine Bernhardt"]},"person":[{"family":"Habelt","role":"aut","given":"Bettina","display":"Habelt, Bettina"},{"family":"Afanasenkau","given":"Dzmitry","role":"aut","display":"Afanasenkau, Dzmitry"},{"family":"Schwarz","display":"Schwarz, Cindy","given":"Cindy","role":"aut"},{"family":"Domanegg","role":"aut","given":"Kevin","display":"Domanegg, Kevin"},{"family":"Kuchar","display":"Kuchar, Martin","role":"aut","given":"Martin"},{"family":"Werner","display":"Werner, Carsten","role":"aut","given":"Carsten"},{"display":"Minev, Ivan R.","role":"aut","given":"Ivan R.","family":"Minev"},{"given":"Rainer","role":"aut","display":"Spanagel, Rainer","family":"Spanagel"},{"role":"aut","given":"Marcus W.","display":"Meinhardt, Marcus W.","family":"Meinhardt"},{"family":"Bernhardt","display":"Bernhardt, Nadine","given":"Nadine","role":"aut"}],"language":["eng"],"title":[{"title_sort":"Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction","title":"Prefrontal electrophysiological biomarkers and mechanism-based drug effects in a rat model of alcohol addiction"}]} | ||
| SRT | |a HABELTBETTPREFRONTAL0520 | ||