Impact of heavy metals on hormonal and immunological factors in women with repeated miscarriages
In 111 women with repeated miscarriages, the urinary excretion of heavy metals was determined in a challenge test with the chelating agent 2,3-dimercaptopropane-l-sulphonic acid in addition to hormonal, chromosomal, immunological and uterine investigations. The heavy metal excretion was correlated t...
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| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 May 1998
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| In: |
Human reproduction update
Year: 1998, Volume: 4, Issue: 3, Pages: 301-309 |
| ISSN: | 1460-2369 |
| DOI: | 10.1093/humupd/4.3.301 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/humupd/4.3.301
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| Author Notes: | I Gerhard, S Waibel, V Daniel, B Runnebaum |
MARC
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| 520 | |a In 111 women with repeated miscarriages, the urinary excretion of heavy metals was determined in a challenge test with the chelating agent 2,3-dimercaptopropane-l-sulphonic acid in addition to hormonal, chromosomal, immunological and uterine investigations. The heavy metal excretion was correlated to different immunological (natural killer cells, T cell subpopulations) and hormonal (progesterone, oestradiol, prolactin, thyroid stimulating hormone) parameters. We conclude that heavy metals seem to have a negative impact on ovarian as well as on pituitary function. The heavy metal-induced immunological changes may interfere with the physiological adaptation of the immune system to the state of pregnancy with the result of a miscarriage. The observed heavy metal-induced hormonal and immunological changes may be important factors in the pathogenesis of repeated miscarriages.Key words:DMPS testing/heavy metals/immunology/ infertility/repeated miscarriages | ||
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