Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells
Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechani...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 18 2024
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| In: |
Journal of experimental medicine
Year: 2024, Jahrgang: 222, Heft: 3, Pages: 1-17, S1-7 |
| ISSN: | 1540-9538 |
| DOI: | 10.1084/jem.20240930 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1084/jem.20240930
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| Verfasserangaben: | Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, and Sonia Tugues |
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| 245 | 1 | 0 | |a Autocrine TGF-β1 drives tissue-specific differentiation and function of resident NK cells |c Colin Sparano, Darío Solís-Sayago, Nathan Sébastien Zangger, Lukas Rindlisbacher, Hannah Van Hove, Marijne Vermeer, Frederike Westermann, Caroline Mussak, Elisa Rallo, Stanislav Dergun, Gioana Litscher, Yishu Xu, Mitchell Bijnen, Christin Friedrich, Melanie Greter, Vanda Juranić Lisnić, Burkhard Becher, Georg Gasteiger, Annette Oxenius, and Sonia Tugues |
| 246 | 1 | |i Titel des übergeordneten Heftes |a Tissue microenvironment and immune memory | |
| 246 | 3 | 3 | |a Autocrine TGF-beta one drives tissue-specific differentiation and function of resident NK cells |
| 264 | 1 | |c December 18 2024 | |
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| 520 | |a Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood. Here, we identify autocrine transforming growth factor-β (TGF-β) as a cell-autonomous driver for NK cell tissue residency across multiple glandular tissues during development. Cell-intrinsic production of TGF-β was continuously required for the maintenance of trNK cells and synergized with Hobit to enhance cytotoxic function. Whereas autocrine TGF-β was redundant in tumors, our study revealed that NK cell-derived TGF-β allowed the expansion of cytotoxic trNK cells during local infection with murine cytomegalovirus (MCMV) and contributed to viral control in the salivary gland. Collectively, our findings reveal tissue-specific regulation of trNK cell differentiation and function by autocrine TGF-β1, which is relevant for antiviral immunity. | ||
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| 700 | 1 | |a Zangger, Nathan Sébastien |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Van Hove, Hannah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vermeer, Marijne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Westermann, Frederike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mussak, Caroline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rallo, Elisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dergun, Stanislav |e VerfasserIn |4 aut | |
| 700 | 1 | |a Litscher, Gioana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Xu, Yishu |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bijnen, Mitchell |e VerfasserIn |4 aut | |
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