The dose of granulocyte colony-stimulating factor administered following cytotoxic chemotherapy is not related to the rebound level of circulating CD34+ haemopoietic progenitor cells during marrow recovery
We report on the RmetHuG-CSF (filgrastim)-related mobilization efficiency in 120 patients with multiple myeloma who received cytotoxic chemotherapy. Three schedules of G-CSF administration starting 24 h after the end of chemotherapy were used: (1) a standard dose of 300 μg/d until the completion of...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1998
|
| In: |
British journal of haematology
Year: 1998, Volume: 101, Issue: 3, Pages: 588-591 |
| ISSN: | 1365-2141 |
| DOI: | 10.1046/j.1365-2141.1998.00730.x |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1046/j.1365-2141.1998.00730.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1365-2141.1998.00730.x |
| Author Notes: | S. Martin-Murea, M.T. Voso, S. Hohaus, M. Pförsich, S. Fruehauf, H. Goldschmidt, U. Hegenbart, and R. Haas |
MARC
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| 245 | 1 | 4 | |a The dose of granulocyte colony-stimulating factor administered following cytotoxic chemotherapy is not related to the rebound level of circulating CD34+ haemopoietic progenitor cells during marrow recovery |c S. Martin-Murea, M.T. Voso, S. Hohaus, M. Pförsich, S. Fruehauf, H. Goldschmidt, U. Hegenbart, and R. Haas |
| 246 | 3 | 3 | |a The dose of granulocyte colony-stimulating factor administered following cytotoxic chemotherapy is not related to the rebound level of circulating CD34 + haemopoietic progenitor cells during marrow recovery |
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| 520 | |a We report on the RmetHuG-CSF (filgrastim)-related mobilization efficiency in 120 patients with multiple myeloma who received cytotoxic chemotherapy. Three schedules of G-CSF administration starting 24 h after the end of chemotherapy were used: (1) a standard dose of 300 μg/d until the completion of PBSC collection; (2) dose escalation from 300 to 600-1200 μg/d during marrow recovery; (3) 600 or 1200 μg/d starting 24 h after cytotoxic chemotherapy. As a result, the individual dose per kg bodyweight varied between 2.83 and 23.08 μg. No relationship was found between the dose of G-CSF administered and the peak level of circulating CD34+ cells or the CD34+ cell counts recorded over the entire collection period. | ||
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