E3 ubiquitin ligase RNF10 promotes dissociation of stalled ribosomes and responds to ribosomal subunit imbalance

Perturbation of protein synthesis causes ribosome stalling on mRNAs. Here, Lehmann et al. demonstrate that the E3 ubiquitin ligase RNF10, through monoubiquitination of RPS3, promotes dissociation of the small ribosomal subunit upon ribosome stalling.

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Bibliographische Detailangaben
Hauptverfasser: Lehmann, Janina A. (VerfasserIn) , Lindner, Doris (VerfasserIn) , Sung, Hsu-Min (VerfasserIn) , Stoecklin, Georg (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 November 2024
In: Nature Communications
Year: 2024, Jahrgang: 15, Pages: 1-14
ISSN:2041-1723
DOI:10.1038/s41467-024-54411-x
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-024-54411-x
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-024-54411-x
Volltext
Verfasserangaben:Janina A. Lehmann, Doris Lindner, Hsu-Min Sung & Georg Stoecklin

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