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CHF6523 data suggest that the phosphoinositide 3-kinase delta isoform is not a suitable target for the management of COPD

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition. Given patients with COPD continue to experience exacerbations despite the availability of effective therapies, anti-inflammatory treatments targeting novel pathways are needed. Kinases, notably the phosphoinositide 3-k...

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Main Authors: Govoni, Mirco (Author) , Bassi, Michele (Author) , Girardello, Luca (Author) , Lucci, Germano (Author) , Rony, François (Author) , Charretier, Rémi (Author) , Galkin, Dmitry (Author) , Faietti, Maria Laura (Author) , Pioselli, Barbara (Author) , Modafferi, Gloria (Author) , Benfeitas, Rui (Author) , Bonatti, Martina (Author) , Miglietta, Daniela (Author) , Clark, Jonathan (Author) , Pedersen, Frauke (Author) , Kirsten, Anne-Marie (Author) , Beeh, Kai-Michael (Author) , Kornmann, Oliver (Author) , Korn, Stephanie (Author) , Ludwig-Sengpiel, Andrea (Author) , Watz, Henrik (Author)
Format: Article (Journal)
Language:English
Published: 19 October 2024
In: Respiratory research
Year: 2024, Volume: 25, Pages: 1-13
ISSN:1465-993X
DOI:10.1186/s12931-024-02999-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12931-024-02999-5
Verlag, kostenfrei, Volltext: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-024-02999-5
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Author Notes:Mirco Govoni, Michele Bassi, Luca Girardello, Germano Lucci, François Rony, Rémi Charretier, Dmitry Galkin, Maria Laura Faietti, Barbara Pioselli, Gloria Modafferi, Rui Benfeitas, Martina Bonatti, Daniela Miglietta, Jonathan Clark, Frauke Pedersen, Anne-Marie Kirsten, Kai-Michael Beeh, Oliver Kornmann, Stephanie Korn, Andrea Ludwig-Sengpiel and Henrik Watz
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Summary:Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory condition. Given patients with COPD continue to experience exacerbations despite the availability of effective therapies, anti-inflammatory treatments targeting novel pathways are needed. Kinases, notably the phosphoinositide 3-kinases (PI3K), are thought to be involved in chronic airway inflammation, with this pathway proposed as a critical regulator of inflammation and oxidative stress response in COPD. CHF6523 is an inhaled PI3Kδ inhibitor that has shown positive preclinical results. This manuscript reports the results of a study of CHF6523 in patients with stable COPD (chronic bronchitis phenotype), and who had evidence of type-2 inflammation.
Item Description:Gesehen am 23.04.2025
Physical Description:Online Resource
ISSN:1465-993X
DOI:10.1186/s12931-024-02999-5

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