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Associations of milk, dairy products, calcium and vitamin D intake with risk of developing Parkinson´s disease within the EPIC4ND cohort

Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 par...

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Main Authors: Gröninger, Mareike (Author) , Sabin, Jara (Author) , Kaaks, Rudolf (Author) , Amiano, Pilar (Author) , Aune, Dagfinn (Author) , Castro, Natalia Cabrera (Author) , Guevara, Marcela (Author) , Hansen, Johnni (Author) , Homann, Jan (Author) , Masala, Giovanna (Author) , Nicolas, Geneviève (Author) , Peters, Susan (Author) , Sacerdote, Carlotta (Author) , Sánchez, Maria-Jose (Author) , De Magistris, Maria Santucci (Author) , Sieri, Sabina (Author) , Vermeulen, Roel (Author) , Zhao, Yujia (Author) , Lill, Christina M. (Author) , Katzke, Verena (Author)
Format: Article (Journal)
Language:English
Published: November 2024
In: European journal of epidemiology
Year: 2024, Volume: 39, Issue: 11, Pages: 1251-1265
ISSN:1573-7284
DOI:10.1007/s10654-024-01183-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s10654-024-01183-9
Verlag, kostenfrei, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s10654-024-01183-9
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Author Notes:Mareike Gröninger, Jara Sabin, Rudolf Kaaks, Pilar Amiano, Dagfinn Aune, Natalia Cabrera Castro, Marcela Guevara, Johnni Hansen, Jan Homann, Giovanna Masala, Geneviève Nicolas, Susan Peters, Carlotta Sacerdote, Maria-Jose Sánchez, Maria Santucci De Magistris, Sabina Sieri, Roel Vermeulen, Yujia Zhao, Christina M. Lill, Verena A. Katzke
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Summary:Literature indicates a potential association between dairy consumption and risk of Parkinson´s disease (PD), especially among men, yet the results remain inconclusive. We investigated this association in a large prospective European cohort. Dietary and non-dietary data was collected from 183,225 participants of the EPIC-for-Neurodegenerative-Diseases (EPIC4ND) cohort, a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Crude and multivariable-adjusted Cox proportional hazards models were employed to examine potential associations between baseline dietary intake of dairy, calcium and vitamin D with incident PD risk. No relationship was observed between dairy consumption (HR 1.07, 95% CI 0.82-1.39), individual dairy products (milk: HR 0.95, 95% CI 0.73-1.23; yogurt: HR 1.03, 95% CI 0.82-1.29; cheese: HR 1.13, 95% CI 0.85-1.51), or vitamin D (HR 1.08, 95% CI 0.80-1.45) with PD risk. However, we observed a risk-increasing association with higher calcium intakes (HR 1.33, 95% CI 1.00-1.78, p for trend = 0.031), which was more pronounced in men (HR 1.50, 95% CI 1.00-2.25, p for trend = 0.044) and in ever smokers (HR 1.64, 95% CI 1.06-2.53, p for trend = 0.014). No compelling evidence was found for an association between dairy products or vitamin D intake and PD risk indicating a potentially limited relevance of dairy intake in PD risk than previously described. Our observations of a positive association between dietary calcium intake and PD risk in men and in ever smokers require further validation.
Item Description:Online veröffentlicht: 3. Dezember 2024
Gesehen am 28.04.2025
Physical Description:Online Resource
ISSN:1573-7284
DOI:10.1007/s10654-024-01183-9

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