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Beneficial microbiome and diet interplay in early-onset colorectal cancer

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in die...

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Autori principali: Zhou, Zhengyuan (Autore) , Kleis, Linda (Autore) , Depetris-Chauvin, Ana (Autore) , Jaskulski, Stefanie (Autore) , Damerell, Victoria (Autore) , Michels, Karin (Autore) , Gigić, Biljana (Autore) , Nöthlings, Ute (Autore) , Panagiotou, Gianni (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: January 2025
In: EMBO molecular medicine
Year: 2025, Volume: 17, Fascicolo: 1, Pages: 9-30
ISSN:1757-4684
DOI:10.1038/s44321-024-00177-0
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s44321-024-00177-0
Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.1038/s44321-024-00177-0
Testo
Note sull'autore:Zhengyuan Zhou, Linda Kleis, Ana Depetris-Chauvin, Stefanie Jaskulski, Victoria Damerell, Karin B Michels, Biljana Gigic, Ute Nöthlings & Gianni Panagiotou
Descrizione
Riassunto:Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Although the risk of developing CRC increases with age, approximately 10% of newly diagnosed cases occur in individuals under the age of 50. Significant changes in dietary habits in young adults since industrialization create a favorable microenvironment for colorectal carcinogenesis. We aim here to shed light on the complex interplay between diet and gut microbiome in the pathogenesis and prevention of early-onset CRC (EO-CRC). We provide an overview of dietary risk factors associated with EO-CRC and contrast them with the general trends for CRC. We delve into gut bacteria, fungi, and phages with potential benefits against CRC and discuss the underlying molecular mechanisms. Furthermore, based on recent findings from human studies, we offer insights into how dietary modifications could potentially enhance gut microbiome composition to mitigate CRC risk. All together, we outline the current research landscape in this area and propose directions for future investigations that could pave the way for novel preventive and therapeutic strategies.
Descrizione del documento:Online veröffentlicht: 9. Dezember 2024
Gesehen am 05.05.2025
Descrizione fisica:Online Resource
ISSN:1757-4684
DOI:10.1038/s44321-024-00177-0

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