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Pervasive sublethal effects of agrochemicals on insects at environmentally relevant concentrations

Insect biomass is declining globally, likely driven by climate change and pesticide use, yet systematic studies on the effects of various chemicals remain limited. In this work, we used a chemical library of 1024 molecules-covering insecticides, herbicides, fungicides, and plant growth inhibitors-to...

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Main Authors: Gándara, Lautaro (Author) , Jacoby, Richard (Author) , Laurent, François (Author) , Spatuzzi, Matteo (Author) , Vlachopoulos, Nikolaos (Author) , Borst, Noa O. (Author) , Ekmen, Gülina (Author) , Potel, Clement M. (Author) , Garrido-Rodriguez, Martin (Author) , Böhmert, Antonia L. (Author) , Misunou, Natalia (Author) , Bartmanski, Bartosz J. (Author) , Li, Xueying C. (Author) , Kutra, Dominik (Author) , Hériché, Jean-Karim (Author) , Tischer, Christian (Author) , Zimmermann-Kogadeeva, Maria (Author) , Ingham, Victoria (Author) , Savitski, Mikhail M. (Author) , Masson, Jean-Baptiste (Author) , Zimmermann, Michael (Author) , Crocker, Justin (Author)
Format: Article (Journal)
Language:English
Published: 25 October 2024
In: Science
Year: 2024, Volume: 386, Issue: 6720, Pages: 446-453
ISSN:1095-9203
DOI:10.1126/science.ado0251
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.ado0251
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Author Notes:Lautaro Gandara, Richard Jacoby, François Laurent, Matteo Spatuzzi, Nikolaos Vlachopoulos, Noa O. Borst, Gülina Ekmen, Clement M. Potel, Martin Garrido-Rodriguez, Antonia L. Böhmert, Natalia Misunou, Bartosz J. Bartmanski, Xueying C. Li, Dominik Kutra, Jean-Karim Hériché, Christian Tischer, Maria Zimmermann-Kogadeeva, Victoria A. Ingham, Mikhail M. Savitski, Jean-Baptiste Masson, Michael Zimmermann, Justin Crocker

MARC

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520 |a Insect biomass is declining globally, likely driven by climate change and pesticide use, yet systematic studies on the effects of various chemicals remain limited. In this work, we used a chemical library of 1024 molecules-covering insecticides, herbicides, fungicides, and plant growth inhibitors-to assess the impact of sublethal pesticide doses on insects. In Drosophila melanogaster, 57% of chemicals affected larval behavior, and a higher proportion compromised long-term survivability. Exposure to sublethal doses also induced widespread changes in the phosphoproteome and changes in development and reproduction. The negative effects of agrochemicals were amplified when the temperature was increased. We observed similar behavioral changes across multiple insect species, including mosquitoes and butterflies. These findings suggest that widespread sublethal pesticide exposure can alter insect behavior and physiology, threatening long-term population survival. 
650 4 |a Agrochemicals 
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650 4 |a Behavior, Animal 
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650 4 |a Dose-Response Relationship, Drug 
650 4 |a Drosophila melanogaster 
650 4 |a Extinction, Biological 
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650 4 |a Insecta 
650 4 |a Insecticides 
650 4 |a Larva 
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650 4 |a Temperature 
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