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Cesarean delivery and blood DNA methylation at birth and childhood: meta-analysis in the Pregnancy and Childhood Epigenetics Consortium

Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between...

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Main Authors: Wang, Siwen (Author) , Casey, Emma (Author) , Sordillo, Joanne (Author) , Aguilar-Lacasaña, Sofía (Author) , Morales Berstein, Fernanda (Author) , Biedrzycki, Richard J. (Author) , Brescianini, Sonia (Author) , Chen, Su (Author) , Hough, Amy (Author) , Isaevska, Elena (Author) , Kim, Woo Jin (Author) , Lecorguillé, Marion (Author) , Li, Sebastian Shaobo (Author) , Page, Christian M. (Author) , Park, Jaehyun (Author) , Röder, Stefan (Author) , Salontaji, Kristina (Author) , Santorelli, Gillian (Author) , Sun, Yidan (Author) , Won, Sungho (Author) , Zillich, Eric (Author) , Zillich, Lea (Author) , Annesi-Maesano, Isabella (Author) , Arshad, S. Hasan (Author) , Bustamante, Mariona (Author) , Cecil, Charlotte A. M. (Author) , Elliott, Hannah R. (Author) , Ewart, Susan (Author) , Felix, Janine F. (Author) , Gagliardi, Luigi (Author) , Håberg, Siri E. (Author) , Herberth, Gunda (Author) , Heude, Barbara (Author) , Holloway, John W. (Author) , Huels, Anke (Author) , Karmaus, Wilfried (Author) , Koppelman, Gerard H. (Author) , London, Stephanie J. (Author) , Mumford, Sunni L. (Author) , Nisticò, Lorenza (Author) , Popovic, Maja (Author) , Rusconi, Franca (Author) , Schisterman, Enrique F. (Author) , Stein, Dan J. (Author) , Send, Tabea (Author) , Tiemeier, Henning (Author) , Vonk, Judith M. (Author) , Vrijheid, Martine (Author) , Wiemels, Joseph Leo (Author) , Witt, Stephanie (Author) , Wright, John (Author) , Yeung, Edwina H. (Author) , Zar, Heather J. (Author) , Zenclussen, Ana C. (Author) , Zhang, Hongmei (Author) , Chavarro, Jorge E. (Author) , Hivert, Marie-France (Author)
Format: Article (Journal)
Language:English
Published: Nov 2024
In: Science advances
Year: 2024, Volume: 10, Issue: 48, Pages: 1-13
ISSN:2375-2548
DOI:10.1126/sciadv.adr2084
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adr2084
Verlag, kostenfrei, Volltext: https://www-science-org.ezproxy.medma.uni-heidelberg.de/doi/10.1126/sciadv.adr2084
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Author Notes:Siwen Wang, Emma Casey, Joanne Sordillo, Sofía Aguilar-Lacasaña, Fernanda Morales Berstein, Richard J. Biedrzycki, Sonia Brescianini, Su Chen, Amy Hough, Elena Isaevska, Woo Jin Kim, Marion Lecorguillé, Sebastian Shaobo Li, Christian M. Page, Jaehyun Park, Stefan Röder, Kristina Salontaji, Gillian Santorelli, Yidan Sun, Sungho Won, Eric Zillich, Lea Zillich, Isabella Annesi-Maesano, S. Hasan Arshad, Mariona Bustamante, Charlotte A. M. Cecil, Hannah R. Elliott, Susan Ewart, Janine F. Felix, Luigi Gagliardi, Siri E. Håberg, Gunda Herberth, Barbara Heude, John W. Holloway, Anke Huels, Wilfried Karmaus, Gerard H. Koppelman, Stephanie J. London, Sunni L. Mumford, Lorenza Nisticò, Maja Popovic, Franca Rusconi, Enrique F. Schisterman, Dan J. Stein, Tabea Send, Henning Tiemeier, Judith M. Vonk, Martine Vrijheid, Joseph Leo Wiemels, Stephanie H. Witt, John Wright, Edwina H. Yeung, Heather J. Zar, Ana C. Zenclussen, Hongmei Zhang, Jorge E. Chavarro, Marie-France Hivert

MARC

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520 |a Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome-wide association studies to examine the associations between delivery mode and blood DNA methylation at birth and its persistence in early childhood. Participants were from 19 pregnancy cohorts (9833 term newborns) and 6 pediatric cohorts (2429 children aged 6 to 10 years). We identified six CpGs in cord blood associated with cesarean delivery (effect size range: 0.4 to 0.7%, P < 1.0 × 10−7): MAP2K2 (cg19423175), LIM2 (cg01500140), CNP (cg13917614), BLM (cg18247172), RASA3 (cg22348356), and RUNX3 (cg20674490), independent of cell proportions and other confounders. In childhood, none of these CpGs were associated with cesarean delivery, and no additional CpGs were identified. Delivery mode was associated with cell proportions at birth but not in childhood. Further research is needed to elucidate cesarean delivery’s molecular influence on offspring health. 
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