A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4: implications for prognosis and clinical trial design
Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated with a younger age at diagnosis and better prognosis than IDH wild-type glioblastoma. Within IDH mutant gliomas, a small fraction of astrocytic tumors present with grade 4 histolog...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 October 2024
|
| In: |
Journal of neuro-oncology
Year: 2025, Volume: 171, Issue: 2, Pages: 373-381 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-024-04852-7 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-024-04852-7 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s11060-024-04852-7 
|
| Author Notes: | Ethan A. Wetzel, Amin I. Nohman, Annie L. Hsieh, David Reuss, Andreas W. Unterberg, Ilker Y. Eyüpoglu, Lingyang Hua, Gilbert Youssef, Patrick Y. Wen, Daniel P. Cahill, Christine Jungk, Tareq A. Juratli, Julie J. Miller |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1925661253 | ||
| 003 | DE-627 | ||
| 005 | 20250717013759.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250514s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11060-024-04852-7 |2 doi | |
| 035 | |a (DE-627)1925661253 | ||
| 035 | |a (DE-599)KXP1925661253 | ||
| 035 | |a (OCoLC)1528045313 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wetzel, Ethan |e VerfasserIn |0 (DE-588)1365609790 |0 (DE-627)1925663655 |4 aut | |
| 245 | 1 | 2 | |a A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 |b implications for prognosis and clinical trial design |c Ethan A. Wetzel, Amin I. Nohman, Annie L. Hsieh, David Reuss, Andreas W. Unterberg, Ilker Y. Eyüpoglu, Lingyang Hua, Gilbert Youssef, Patrick Y. Wen, Daniel P. Cahill, Christine Jungk, Tareq A. Juratli, Julie J. Miller |
| 264 | 1 | |c 21 October 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.05.2025 | ||
| 520 | |a Mutations in the Isocitrate Dehydrogenase (IDH) genes, IDH1 or IDH2, define a group of adult diffuse gliomas associated with a younger age at diagnosis and better prognosis than IDH wild-type glioblastoma. Within IDH mutant gliomas, a small fraction of astrocytic tumors present with grade 4 histologic features and poor prognosis. In molecular studies, homozygous deletion of CDKN2A/B is independently predictive of poor prognosis and short survival. As a consequence, 2021 WHO classification now also recognizes this molecular feature, CDKN2A/B deletion, as sufficient for classifying an astrocytoma as IDH-mutant, WHO Grade 4, regardless of histological grading. Here, we investigate outcomes of patients with WHO Grade 4 IDH-mutant astrocytoma both with and without CDKN2A/B deletion, to compare these groups and evaluate clinical and radiographic factors that contribute to survival. | ||
| 650 | 4 | |a Astrocyte | |
| 650 | 4 | |a Astrocytoma | |
| 650 | 4 | |a Brain Cancer | |
| 650 | 4 | |a CDKN2A/B homozygous deletion | |
| 650 | 4 | |a Gene Mutation | |
| 650 | 4 | |a Glioma | |
| 650 | 4 | |a Huntington's disease | |
| 650 | 4 | |a Idiopathic thrombocytopaenic purpura | |
| 650 | 4 | |a Isocitrate dehydrogenase (IDH) | |
| 650 | 4 | |a WHO grade 4 | |
| 650 | 4 | |a Wilms tumour | |
| 700 | 1 | |a Nohman, Amin |e VerfasserIn |0 (DE-588)131408643X |0 (DE-627)1876405139 |4 aut | |
| 700 | 1 | |a Hsieh, Annie L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Reuss, David |d 1976- |e VerfasserIn |0 (DE-588)143839837 |0 (DE-627)655107894 |0 (DE-576)339294337 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Eyüpoglu, Ilker Yasin |d 1974- |e VerfasserIn |0 (DE-588)129880736 |0 (DE-627)482776692 |0 (DE-576)297884204 |4 aut | |
| 700 | 1 | |a Hua, Lingyang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Youssef, Gilbert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wen, Patrick Y. |e VerfasserIn |0 (DE-588)1205842608 |0 (DE-627)1691570818 |4 aut | |
| 700 | 1 | |a Cahill, Daniel P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jungk, Christine |e VerfasserIn |0 (DE-588)1051888247 |0 (DE-627)78696765X |0 (DE-576)407515968 |4 aut | |
| 700 | 1 | |a Juratli, Tareq |d 1982- |e VerfasserIn |0 (DE-588)132866250 |0 (DE-627)527876526 |0 (DE-576)299468127 |4 aut | |
| 700 | 1 | |a Miller, Julie J. |e VerfasserIn |0 (DE-588)1208652966 |0 (DE-627)169496986X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neuro-oncology |d Dordrecht [u.a.] : Springer Science + Business Media B.V, 1983 |g 171(2025), 2, Seite 373-381 |h Online-Ressource |w (DE-627)32046122X |w (DE-600)2007293-4 |w (DE-576)107058944 |x 1573-7373 |7 nnas |a A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 implications for prognosis and clinical trial design |
| 773 | 1 | 8 | |g volume:171 |g year:2025 |g number:2 |g pages:373-381 |g extent:9 |a A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 implications for prognosis and clinical trial design |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s11060-024-04852-7 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/article/10.1007/s11060-024-04852-7 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250514 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1051888247 |a Jungk, Christine |m 1051888247:Jungk, Christine |d 910000 |d 912000 |d 50000 |e 910000PJ1051888247 |e 912000PJ1051888247 |e 50000PJ1051888247 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 11 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |d 910000 |d 911000 |e 910000PU1032681187 |e 911200PU1032681187 |e 910000PU1032681187 |e 911000PU1032681187 |k 0/910000/ |k 1/910000/911200/ |k 0/910000/ |k 1/910000/911000/ |p 5 | ||
| 998 | |g 143839837 |a Reuss, David |m 143839837:Reuss, David |d 910000 |d 912000 |d 50000 |e 910000PR143839837 |e 912000PR143839837 |e 50000PR143839837 |k 0/910000/ |k 1/910000/912000/ |k 0/50000/ |p 4 | ||
| 998 | |g 131408643X |a Nohman, Amin I. |m 131408643X:Nohman, Amin I. |d 910000 |d 911200 |e 910000PN131408643X |e 911200PN131408643X |k 0/910000/ |k 1/910000/911200/ |p 2 | ||
| 999 | |a KXP-PPN1925661253 |e 4724406895 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"physDesc":[{"extent":"9 S.","noteIll":"Illustrationen"}],"relHost":[{"note":["Gesehen am 11.06.2018","Fortsetzung der Druck-Ausgabe"],"title":[{"title":"Journal of neuro-oncology","title_sort":"Journal of neuro-oncology"}],"pubHistory":["1.1983 -"],"origin":[{"dateIssuedKey":"1983","dateIssuedDisp":"1983-","publisher":"Springer Science + Business Media B.V ; Kluwer","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"disp":"A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4 implications for prognosis and clinical trial designJournal of neuro-oncology","part":{"text":"171(2025), 2, Seite 373-381","year":"2025","issue":"2","extent":"9","volume":"171","pages":"373-381"},"language":["eng"],"recId":"32046122X","id":{"eki":["32046122X"],"issn":["1573-7373"],"zdb":["2007293-4"]}}],"name":{"displayForm":["Ethan A. Wetzel, Amin I. Nohman, Annie L. Hsieh, David Reuss, Andreas W. Unterberg, Ilker Y. Eyüpoglu, Lingyang Hua, Gilbert Youssef, Patrick Y. Wen, Daniel P. Cahill, Christine Jungk, Tareq A. Juratli, Julie J. Miller"]},"id":{"doi":["10.1007/s11060-024-04852-7"],"eki":["1925661253"]},"recId":"1925661253","note":["Gesehen am 14.05.2025"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"21 October 2024"}],"title":[{"subtitle":"implications for prognosis and clinical trial design","title_sort":"multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4","title":"A multi-center, clinical analysis of IDH-mutant gliomas, WHO Grade 4"}],"person":[{"family":"Wetzel","given":"Ethan","display":"Wetzel, Ethan","role":"aut"},{"family":"Nohman","given":"Amin","display":"Nohman, Amin","role":"aut"},{"given":"Annie L.","family":"Hsieh","display":"Hsieh, Annie L.","role":"aut"},{"display":"Reuss, David","family":"Reuss","given":"David","role":"aut"},{"role":"aut","family":"Unterberg","given":"Andreas","display":"Unterberg, Andreas"},{"role":"aut","family":"Eyüpoglu","given":"Ilker Yasin","display":"Eyüpoglu, Ilker Yasin"},{"display":"Hua, Lingyang","given":"Lingyang","family":"Hua","role":"aut"},{"family":"Youssef","given":"Gilbert","display":"Youssef, Gilbert","role":"aut"},{"role":"aut","given":"Patrick Y.","family":"Wen","display":"Wen, Patrick Y."},{"given":"Daniel P.","family":"Cahill","display":"Cahill, Daniel P.","role":"aut"},{"given":"Christine","family":"Jungk","display":"Jungk, Christine","role":"aut"},{"display":"Juratli, Tareq","family":"Juratli","given":"Tareq","role":"aut"},{"role":"aut","display":"Miller, Julie J.","given":"Julie J.","family":"Miller"}]} | ||
| SRT | |a WETZELETHAMULTICENTE2120 | ||