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Dual effect of nicotine on cardiac noradrenaline release during metabolic blockade

Nicotine-induced noradrenaline was investigated in perfused guinea pig hearts subjected to metabolic blockade that was caused either by anoxia or by cyanide intoxication. Noradrenaline, neuropeptide Y, and dihydroxyphenylethyleneglycol (DOPEG) were determined in the coronary venous overflow. Neurope...

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Hauptverfasser: Richardt, Gert (VerfasserIn) , Brenn, T. (VerfasserIn) , Seyfarth, M. (VerfasserIn) , Haass, Markus (VerfasserIn) , Schömig, Edgar (VerfasserIn) , Schömig, Albert (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: November 1994
In: Basic research in cardiology
Year: 1994, Jahrgang: 89, Heft: 6, Pages: 524-534
ISSN:1435-1803
DOI:10.1007/BF00794952
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF00794952
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Verfasserangaben:G. Richardt, T. Brenn, M. Seyfarth, M. Haass, E. Schömig, A. Schömig
Beschreibung
Zusammenfassung:Nicotine-induced noradrenaline was investigated in perfused guinea pig hearts subjected to metabolic blockade that was caused either by anoxia or by cyanide intoxication. Noradrenaline, neuropeptide Y, and dihydroxyphenylethyleneglycol (DOPEG) were determined in the coronary venous overflow. Neuropeptide Y is a sympathetic cotransmitter of nordrenaline, and concomitant release of both transmitters indicates an exocytotic, calcium-dependent release mechanism, whereas neuropeptide Y overflow does not occur during nonexocytotic noradrenaline release. Nonexocytotic, calcium-independent noradrenaline release, however, is associated with an increase of DOPEG overflow, which is the main intraneuronal metabolite of noradrenaline formed by monoamine oxidase if oxygen is present.
Beschreibung:Gesehen am 20.05.2025
Beschreibung:Online Resource
ISSN:1435-1803
DOI:10.1007/BF00794952

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