Towards a better diagnosis and treatment of dementia: Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia
Alzheimer's disease (AD) and vascular dementia (VaD) together contribute to almost 90 % of all dementia cases leading to major health challenges of our time with a substantial global socioeconomic burden. While in AD, the improved understanding of Amyloid beta (Aß) mismetabolism and tau hyperph...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
|
| In: |
Neurobiology of disease
Year: 2025, Jahrgang: 208, Pages: 1-21 |
| ISSN: | 1095-953X |
| DOI: | 10.1016/j.nbd.2025.106845 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.nbd.2025.106845 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0969996125000610 
|
| Verfasserangaben: | Alisa Vollhardt, Lutz Frölich, Anna Christina Stockbauer, Adrian Danek, Christoph Schmitz, Anna-Sophia Wahl |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1926589750 | ||
| 003 | DE-627 | ||
| 005 | 20250913141534.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250526s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.nbd.2025.106845 |2 doi | |
| 035 | |a (DE-627)1926589750 | ||
| 035 | |a (DE-599)KXP1926589750 | ||
| 035 | |a (OCoLC)1528045612 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Vollhardt, Alisa |e VerfasserIn |0 (DE-588)1318489342 |0 (DE-627)1880104423 |4 aut | |
| 245 | 1 | 0 | |a Towards a better diagnosis and treatment of dementia |b Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia |c Alisa Vollhardt, Lutz Frölich, Anna Christina Stockbauer, Adrian Danek, Christoph Schmitz, Anna-Sophia Wahl |
| 264 | 1 | |c May 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 21 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 24. Februar 2025, Artikelversion: 13. März 2025 | ||
| 500 | |a Gesehen am 26.05.2025 | ||
| 520 | |a Alzheimer's disease (AD) and vascular dementia (VaD) together contribute to almost 90 % of all dementia cases leading to major health challenges of our time with a substantial global socioeconomic burden. While in AD, the improved understanding of Amyloid beta (Aß) mismetabolism and tau hyperphosphorylation as pathophysiological hallmarks has led to significant clinical breakthroughs, similar advances in VaD are lacking. After comparing the clinical presentation, including risk factors, disease patterns, course of diseases and further diagnostic parameters for both forms of dementia, we highlight the importance of shared pathomechanisms found in AD and VaD: Endothelial damage, blood brain barrier (BBB) breakdown and hypoperfusion inducing oxidative stress and inflammation and thus trophic uncoupling in the neurovascular unit. A dysfunctional endothelium and BBB lead to the accumulation of neurotoxic molecules and Aß through impaired clearance, which in turn leads to neurodegeneration. In this context we discuss possible neuropathological parameters, which might serve as biomarkers and thus improve diagnostic accuracy or reveal targets for novel therapeutic strategies for both forms of dementia. | ||
| 650 | 4 | |a Alzheimer's | |
| 650 | 4 | |a Endothelial damage | |
| 650 | 4 | |a Impaired blood brain barrier | |
| 650 | 4 | |a Neurotoxic metabolites | |
| 650 | 4 | |a Neurovascular coupling | |
| 650 | 4 | |a Neurovascular unit | |
| 650 | 4 | |a Vascular dementia | |
| 700 | 1 | |a Frölich, Lutz |d 1956- |e VerfasserIn |0 (DE-588)1028327099 |0 (DE-627)730567516 |0 (DE-576)375813160 |4 aut | |
| 700 | 1 | |a Stockbauer, Anna Christina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Danek, Adrian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schmitz, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wahl, Anna-Sophia |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neurobiology of disease |d [Amsterdam] : Elsevier, 1994 |g 208(2025), Artikel-ID 106845, Seite 1-21 |h Online-Ressource |w (DE-627)268125414 |w (DE-600)1471408-5 |w (DE-576)27234947X |x 1095-953X |7 nnas |a Towards a better diagnosis and treatment of dementia Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia |
| 773 | 1 | 8 | |g volume:208 |g year:2025 |g elocationid:106845 |g pages:1-21 |g extent:21 |a Towards a better diagnosis and treatment of dementia Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.nbd.2025.106845 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0969996125000610 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250526 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1028327099 |a Frölich, Lutz |m 1028327099:Frölich, Lutz |d 60000 |e 60000PF1028327099 |k 0/60000/ |p 2 | ||
| 999 | |a KXP-PPN1926589750 |e 4728043290 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Vollhardt","display":"Vollhardt, Alisa","role":"aut","given":"Alisa"},{"given":"Lutz","role":"aut","family":"Frölich","display":"Frölich, Lutz"},{"given":"Anna Christina","role":"aut","family":"Stockbauer","display":"Stockbauer, Anna Christina"},{"given":"Adrian","role":"aut","family":"Danek","display":"Danek, Adrian"},{"display":"Schmitz, Christoph","family":"Schmitz","role":"aut","given":"Christoph"},{"given":"Anna-Sophia","role":"aut","display":"Wahl, Anna-Sophia","family":"Wahl"}],"language":["eng"],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"May 2025"}],"note":["Online verfügbar: 24. Februar 2025, Artikelversion: 13. März 2025","Gesehen am 26.05.2025"],"title":[{"title":"Towards a better diagnosis and treatment of dementia","title_sort":"Towards a better diagnosis and treatment of dementia","subtitle":"Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementia"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Alisa Vollhardt, Lutz Frölich, Anna Christina Stockbauer, Adrian Danek, Christoph Schmitz, Anna-Sophia Wahl"]},"physDesc":[{"noteIll":"Illustrationen","extent":"21 S."}],"recId":"1926589750","relHost":[{"language":["eng"],"titleAlt":[{"title":"Experimental neurology / B"}],"part":{"volume":"208","extent":"21","text":"208(2025), Artikel-ID 106845, Seite 1-21","pages":"1-21","year":"2025"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"268125414","id":{"eki":["268125414"],"issn":["1095-953X"],"zdb":["1471408-5"]},"title":[{"title":"Neurobiology of disease","title_sort":"Neurobiology of disease"}],"note":["Gesehen am 18.10.2022"],"pubHistory":["1.1994 -"],"origin":[{"dateIssuedDisp":"1994-","dateIssuedKey":"1994","publisher":"Elsevier ; Academic Press","publisherPlace":"[Amsterdam] ; Orlando, Fla."}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Towards a better diagnosis and treatment of dementia Identifying common and distinct neuropathological mechanisms in Alzheimer's and vascular dementiaNeurobiology of disease"}],"id":{"eki":["1926589750"],"doi":["10.1016/j.nbd.2025.106845"]}} | ||
| SRT | |a VOLLHARDTATOWARDSABE2025 | ||