Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study
The goal of treatment in patients with pulmonary arterial hypertension is to achieve a low risk status, indicating a favorable long-term outcome. The REPLACE study investigated the efficacy of switching to riociguat in patients with pulmonary arterial hypertension and an insufficient response to pho...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 December 2020
|
| In: |
Pulmonary circulation
Year: 2020, Jahrgang: 10, Heft: 4, Pages: 1-8 |
| ISSN: | 2045-8940 |
| DOI: | 10.1177/2045894020973124 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/2045894020973124 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1177/2045894020973124 
|
| Verfasserangaben: | Gérald Simonneau, Hossein-Ardeschir Ghofrani, Paul A. Corris, Stephan Rosenkranz, Ekkehard Grünig, Jim White, Vallerie V. McLaughlin, David Langleben, Christian Meier, Dennis Busse, Frank Kleinjung and Raymond L. Benza |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1926614658 | ||
| 003 | DE-627 | ||
| 005 | 20250717015332.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250526s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/2045894020973124 |2 doi | |
| 035 | |a (DE-627)1926614658 | ||
| 035 | |a (DE-599)KXP1926614658 | ||
| 035 | |a (OCoLC)1528045690 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Simonneau, Gérald |e VerfasserIn |0 (DE-588)1366805895 |0 (DE-627)1926614232 |4 aut | |
| 245 | 1 | 0 | |a Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study |c Gérald Simonneau, Hossein-Ardeschir Ghofrani, Paul A. Corris, Stephan Rosenkranz, Ekkehard Grünig, Jim White, Vallerie V. McLaughlin, David Langleben, Christian Meier, Dennis Busse, Frank Kleinjung and Raymond L. Benza |
| 264 | 1 | |c 01 December 2020 | |
| 300 | |b Illustrationen | ||
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.05.2025 | ||
| 520 | |a The goal of treatment in patients with pulmonary arterial hypertension is to achieve a low risk status, indicating a favorable long-term outcome. The REPLACE study investigated the efficacy of switching to riociguat in patients with pulmonary arterial hypertension and an insufficient response to phosphodiesterase-5 inhibitors. In this post hoc analysis, we applied the REPLACE composite endpoint of clinical improvement to the placebo-controlled PATENT-1 study of riociguat in pulmonary arterial hypertension and its long-term extension, PATENT-2. Clinical improvement was defined as ≥2 of the following in patients who completed the study without clinical worsening: ≥10% or ≥30 m improvement in 6-minute walking distance; World Health Organization functional class I or II; ≥30% decrease in N-terminal prohormone of brain natriuretic peptide. At PATENT-1 Week 12, patients treated with riociguat were more likely to achieve the composite endpoint vs. placebo (P < 0.0001), with similar results in pretreated (P = 0.0189) and treatment-naïve (P < 0.0001) patients. Achievement of the composite endpoint at Week 12 was associated with a 45% reduction in relative risk of death and a 19% reduction in relative risk of clinical worsening in PATENT-2. Overall, these data suggest that use of the REPLACE composite endpoint in patients with pulmonary arterial hypertension is a valid assessment of response to treatment. | ||
| 650 | 4 | |a clinical worsening | |
| 650 | 4 | |a Pulmonary arterial hypertension | |
| 650 | 4 | |a soluble guanylate cyclase (sGC) stimulator | |
| 650 | 4 | |a survival | |
| 700 | 1 | |a Ghofrani, Hossein-Ardeschir |e VerfasserIn |4 aut | |
| 700 | 1 | |a Corris, Paul A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rosenkranz, Stephan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grünig, Ekkehard |e VerfasserIn |0 (DE-588)112535801 |0 (DE-627)618892605 |0 (DE-576)31856694X |4 aut | |
| 700 | 1 | |a White, Jim |e VerfasserIn |4 aut | |
| 700 | 1 | |a McLaughlin, Vallerie V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Langleben, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meier, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Busse, Dennis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kleinjung, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benza, Raymond L. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pulmonary circulation |d Hoboken, NJ : Wiley, 2011 |g 10(2020), 4 vom: Dez., Seite 1-8 |h Online-Ressource |w (DE-627)672806649 |w (DE-600)2638089-4 |w (DE-576)353570435 |x 2045-8940 |7 nnas |a Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study |
| 773 | 1 | 8 | |g volume:10 |g year:2020 |g number:4 |g month:12 |g pages:1-8 |g extent:8 |a Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study |
| 856 | 4 | 0 | |u https://doi.org/10.1177/2045894020973124 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1177/2045894020973124 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250526 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 112535801 |a Grünig, Ekkehard |m 112535801:Grünig, Ekkehard |d 910000 |d 950000 |d 950900 |d 50000 |e 910000PG112535801 |e 950000PG112535801 |e 950900PG112535801 |e 50000PG112535801 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950900/ |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1926614658 |e 4728095355 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"01 December 2020","dateIssuedKey":"2020"}],"id":{"doi":["10.1177/2045894020973124"],"eki":["1926614658"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"8 S."}],"person":[{"role":"aut","given":"Gérald","family":"Simonneau","display":"Simonneau, Gérald"},{"role":"aut","family":"Ghofrani","display":"Ghofrani, Hossein-Ardeschir","given":"Hossein-Ardeschir"},{"given":"Paul A.","family":"Corris","display":"Corris, Paul A.","role":"aut"},{"role":"aut","family":"Rosenkranz","display":"Rosenkranz, Stephan","given":"Stephan"},{"role":"aut","family":"Grünig","display":"Grünig, Ekkehard","given":"Ekkehard"},{"role":"aut","given":"Jim","family":"White","display":"White, Jim"},{"display":"McLaughlin, Vallerie V.","family":"McLaughlin","given":"Vallerie V.","role":"aut"},{"role":"aut","given":"David","display":"Langleben, David","family":"Langleben"},{"given":"Christian","family":"Meier","display":"Meier, Christian","role":"aut"},{"role":"aut","display":"Busse, Dennis","family":"Busse","given":"Dennis"},{"role":"aut","display":"Kleinjung, Frank","family":"Kleinjung","given":"Frank"},{"role":"aut","display":"Benza, Raymond L.","family":"Benza","given":"Raymond L."}],"title":[{"title_sort":"Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study","title":"Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT study"}],"relHost":[{"origin":[{"dateIssuedKey":"2011","publisher":"Wiley ; Medknow Publ. ; Univ. of Chicago Press ; Sage Publications","dateIssuedDisp":"2011-","publisherPlace":"Hoboken, NJ ; Mumbai ; Chicago, Ill. ; Thousand Oaks, CA"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"eki":["672806649"],"zdb":["2638089-4"],"issn":["2045-8940"]},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"official journal of the Pulmonary Vascular Research Institute","title":"Pulmonary circulation","title_sort":"Pulmonary circulation"}],"part":{"extent":"8","year":"2020","issue":"4","volume":"10","text":"10(2020), 4 vom: Dez., Seite 1-8","pages":"1-8"},"disp":"Assessment of the REPLACE study composite endpoint in riociguat-treated patients in the PATENT studyPulmonary circulation","pubHistory":["1.2011 -"],"note":["Gesehen am 26.07.2024"],"recId":"672806649"}],"name":{"displayForm":["Gérald Simonneau, Hossein-Ardeschir Ghofrani, Paul A. Corris, Stephan Rosenkranz, Ekkehard Grünig, Jim White, Vallerie V. McLaughlin, David Langleben, Christian Meier, Dennis Busse, Frank Kleinjung and Raymond L. Benza"]},"recId":"1926614658","note":["Gesehen am 26.05.2025"]} | ||
| SRT | |a SIMONNEAUGASSESSMENT0120 | ||