Self-reported financial difficulties of colorectal cancer patients 1 year after start of treatment
Background - The purpose of this study is to investigate self-reported financial difficulties (FDs) in patients with colorectal cancer (CRC) and to develop easy-to-implement models to predict FDs 1 year after initiation of CRC treatment. - Materials and methods - In the prospective EDIUM cohort, CRC...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
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| In: |
ESMO open
Year: 2025, Jahrgang: 10, Heft: 5, Pages: 1-9 |
| ISSN: | 2059-7029 |
| DOI: | 10.1016/j.esmoop.2025.105078 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.esmoop.2025.105078 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2059702925009470 
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| Verfasserangaben: | N.T. Sibert, C. Breidenbach, S.R. Benz, S. Post, T. Seufferlein, C. Ackermann, R.D. Blossey, G. Böhm, F. Brennfleck, J. Bunse, M.-H. Dahlke, J. Egetemeyer, S. Elhabash, N. Emmanouilidis, S. Flemming, B. Freitag, K. Goetzky, E. von Haeften, M. Henschel, S. Hollerbach, J. Höppner, M. Kim, C. Klein, C. Klinik, B. Klump, J. Köninger, L. D.-G. Lee, L. Mirow, J. Ockenga, S. Petzoldt, P.A. Neumann, P. Piso, C. Reißfelder, A. Rickenberger, M. Riechmann, J. Rolinger, R. Rosenberg, D. Schilawa, J. Schmidt, M.W. Schnell, D. Steinemann, D. Varga-Szabó, R. Wahba, D. Weyhe, F. Willeke, U. Wirth, U. Wittel, C.B. Zielinski, V. Kolb & C. Kowalski |
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| 245 | 1 | 0 | |a Self-reported financial difficulties of colorectal cancer patients 1 year after start of treatment |c N.T. Sibert, C. Breidenbach, S.R. Benz, S. Post, T. Seufferlein, C. Ackermann, R.D. Blossey, G. Böhm, F. Brennfleck, J. Bunse, M.-H. Dahlke, J. Egetemeyer, S. Elhabash, N. Emmanouilidis, S. Flemming, B. Freitag, K. Goetzky, E. von Haeften, M. Henschel, S. Hollerbach, J. Höppner, M. Kim, C. Klein, C. Klinik, B. Klump, J. Köninger, L. D.-G. Lee, L. Mirow, J. Ockenga, S. Petzoldt, P.A. Neumann, P. Piso, C. Reißfelder, A. Rickenberger, M. Riechmann, J. Rolinger, R. Rosenberg, D. Schilawa, J. Schmidt, M.W. Schnell, D. Steinemann, D. Varga-Szabó, R. Wahba, D. Weyhe, F. Willeke, U. Wirth, U. Wittel, C.B. Zielinski, V. Kolb & C. Kowalski |
| 264 | 1 | |c May 2025 | |
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| 500 | |a Online verfügbar: 2. Mai 2025, Artikelversion: 2. Mai 2025 | ||
| 500 | |a Gesehen am 26.05.2025 | ||
| 520 | |a Background - The purpose of this study is to investigate self-reported financial difficulties (FDs) in patients with colorectal cancer (CRC) and to develop easy-to-implement models to predict FDs 1 year after initiation of CRC treatment. - Materials and methods - In the prospective EDIUM cohort, CRC patients are asked to complete the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and QLQ-CR29 before (T0) and 1 year after initiation of treatment (T1). These patient-reported outcomes are combined with sociodemographic and clinical data. The QLQ-C30 ‘FD’ item is firstly analysed descriptively, together with covariates. Logistic lasso regression was carried out to develop a predictive model (full model) of FDs at T1, and its predictive capacity was assessed. This predictive model was then simplified using easy-to-collect predictors which showed importance in the full model. - Results - Of 9124 CRC patients enrolled between October 2018 and May 2023, 6061 completed follow-up questionnaires (T1). Of those initially without FDs (n = 4989), 25% (1248 patients) reported new FDs at T1. These patients were younger [median age 66 versus 72 years; odds ratio (OR) 2.81 (95% confidence interval [CI] 2.46-3.22)] and had a higher proportion of lower educational attainment [74% versus 69%; OR 1.32 (95% CI 1.14-1.54)]. Clinically, FDs were more frequently reported by patients with higher International Union Against Cancer (UICC) stages [48% in stages III/IV versus 32.5% in stages I/II; OR 1.98 (95% CI 1.74-2.26)] and rectal cancer [37% versus 28%; OR 1.52 (95% CI 1.32-1.73)]. The full model [based on a test and training dataset of n = 5910 patients, including 14 predictors, area under the curve (AUC) 0.75] was reduced to two simplified models with only the predictors age, sex (model 1, AUC 0.72)/localisation of tumour (model 2), and FDs at T0 (AUC = 0.74). On this basis, two risk assessment tables were developed. - Conclusions - A significant proportion of CRC patients report FDs 1 year after treatment initiation, particularly among socioeconomically disadvantaged groups. Together with the predictive models and two ready-to-use risk assessment tables, these findings can be utilised by clinicians and psychosocial counselling services to provide tailored support options. | ||
| 650 | 4 | |a colorectal cancer | |
| 650 | 4 | |a financial toxicity | |
| 650 | 4 | |a patient-reported outcomes | |
| 650 | 4 | |a socioeconomic impact | |
| 700 | 1 | |a Breidenbach, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benz, S. R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Post, Stefan |d 1954- |e VerfasserIn |0 (DE-588)1026227518 |0 (DE-627)726294667 |0 (DE-576)371524598 |4 aut | |
| 700 | 1 | |a Seufferlein, T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ackermann, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blossey, R. D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Böhm, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brennfleck, F. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bunse, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dahlke, M. -H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Egetemeyer, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Elhabash, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Emmanouilidis, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flemming, S. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Goetzky, K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Haeften, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henschel, M. |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Petzoldt, S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neumann, P. A. |e VerfasserIn |4 aut | |
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