Cover Image

First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma: a multicenter study from the prospective skin cancer registry ADOREG

Background - Melanoma is the main cause of skin cancer-related death. Treatment with immune checkpoint inhibitors (CPI) has improved the prognosis in recent years. However, subtypes of melanoma differ in their response. Acral lentiginous melanoma (ALM) has a worse prognosis compared to cutaneous mel...

Full description

Saved in:
Bibliographic Details
Main Authors: Reinhard, Sören (Author) , Utikal, Jochen (Author) , Zaremba, Anne (Author) , Lodde, Georg (Author) , von Wasielewski, Imke (Author) , Klespe, Kai Christian (Author) , Meier, Friedegund (Author) , Haferkamp, Sebastian (Author) , Kähler, Katharina C. (Author) , Herbst, Rudolf (Author) , Gebhardt, Christoffer (Author) , Sindrilaru, Anca (Author) , Dippel, Edgar (Author) , Angela, Yenny (Author) , Mohr, Peter (Author) , Pfoehler, Claudia (Author) , Forschner, Andrea (Author) , Kaatz, Martin (Author) , Schell, Beatrice (Author) , Gesierich, Anja (Author) , Loquai, Carmen (Author) , Hassel, Jessica C. (Author) , Ulrich, Jens (Author) , Meiß, Frank (Author) , Schley, Gaston (Author) , Heinzerling, Lucie M. (Author) , Sachse, Michael (Author) , Welzel, Julia (Author) , Weishaupt, Carsten (Author) , Sunderkötter, Cord (Author) , Michl, Christiane (Author) , Lindhof, Harm-Henning (Author) , Kreuter, Alexander (Author) , Heppt, Markus V. (Author) , Wenk, Saskia (Author) , Mauch, Cornelia (Author) , Berking, Carola (Author) , Nedwed, Annekathrin Silvia (Author) , Gutzmer, Ralf (Author) , Leiter, Ulrike (Author) , Schadendorf, Dirk (Author) , Ugurel, Selma (Author) , Weichenthal, Michael (Author) , Haist, Maximilian (Author) , Fleischer, Maria Isabel (Author) , Lang, Berenice (Author) , Grabbe, Stephan (Author) , Stege, Henner (Author)
Format: Article (Journal)
Language:English
Published: 2 May 2025
In: European journal of cancer
Year: 2025, Volume: 220, Pages: 1-10
ISSN:1879-0852
DOI:10.1016/j.ejca.2025.115356
Online Access:Resolving-System, kostenfrei: https://doi.org/10.1016/j.ejca.2025.115356
Resolving-System, kostenfrei: https://doi.org/10.25673/119034
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804925001376
Get full text
Author Notes:Sören Reinhard, Jochen Sven Utikal, Anne Zaremba, Georg Lodde, Imke von Wasielewski, Kai Christian Klespe, Friedegund Meier, Sebastian Haferkamp, Katharina C. Kähler, Rudolf Herbst, Christoffer Gebhardt, Anca Sindrilaru, Edgar Dippel, Yenny Angela, Peter Mohr, Claudia Pfoehler, Andrea Forschner, Martin Kaatz, Beatrice Schell, Anja Gesierich, Carmen Loquai, Jessica C. Hassel, Jens Ulrich, Frank Meiss, Gaston Schley, Lucie M. Heinzerling, Michael Sachse, Julia Welzel, Carsten Weishaupt, Cord Sunderkötter, Christiane Michl, Harm-Henning Lindhof, Alexander Kreuter, Markus V. Heppt, Saskia Wenk, Cornelia Mauch, Carola Berking, Annekathrin Silvia Nedwed, Ralf Gutzmer, Ulrike Leiter, Dirk Schadendorf, Selma Ugurel, Michael Weichenthal, Maximilian Haist, Maria Isabel Fleischer, Berenice Lang, Stephan Grabbe, Henner Stege

MARC

LEADER 00000caa a2200000 c 4500
001 1926689909
003 DE-627
005 20251111092933.0
007 cr uuu---uuuuu
008 250527s2025 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ejca.2025.115356  |2 doi 
024 7 |a 10.25673/119034  |2 doi 
035 |a (DE-627)1926689909 
035 |a (DE-599)KXP1926689909 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Reinhard, Sören  |d 1987-  |e VerfasserIn  |0 (DE-588)1179476042  |0 (DE-627)106737809X  |0 (DE-576)51825125X  |4 aut 
245 1 0 |a First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma  |b a multicenter study from the prospective skin cancer registry ADOREG  |c Sören Reinhard, Jochen Sven Utikal, Anne Zaremba, Georg Lodde, Imke von Wasielewski, Kai Christian Klespe, Friedegund Meier, Sebastian Haferkamp, Katharina C. Kähler, Rudolf Herbst, Christoffer Gebhardt, Anca Sindrilaru, Edgar Dippel, Yenny Angela, Peter Mohr, Claudia Pfoehler, Andrea Forschner, Martin Kaatz, Beatrice Schell, Anja Gesierich, Carmen Loquai, Jessica C. Hassel, Jens Ulrich, Frank Meiss, Gaston Schley, Lucie M. Heinzerling, Michael Sachse, Julia Welzel, Carsten Weishaupt, Cord Sunderkötter, Christiane Michl, Harm-Henning Lindhof, Alexander Kreuter, Markus V. Heppt, Saskia Wenk, Cornelia Mauch, Carola Berking, Annekathrin Silvia Nedwed, Ralf Gutzmer, Ulrike Leiter, Dirk Schadendorf, Selma Ugurel, Michael Weichenthal, Maximilian Haist, Maria Isabel Fleischer, Berenice Lang, Stephan Grabbe, Henner Stege 
264 1 |c 2 May 2025 
300 |b Illustrationen 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 15. März 2025, Artikelversion: 22. März 2025 
500 |a Gesehen am 28.05.2025 
520 |a Background - Melanoma is the main cause of skin cancer-related death. Treatment with immune checkpoint inhibitors (CPI) has improved the prognosis in recent years. However, subtypes of melanoma differ in their response. Acral lentiginous melanoma (ALM) has a worse prognosis compared to cutaneous melanoma other than ALM (CM) and is therefore of particular relevance. - Aims - To evaluate the efficacy of CPI in first-line treatment of patients with advanced ALM compared CM. - Methods - Retrospective analysis of patients with metastatic ALM (n=45) or CM (n=328) who received first-line CPI therapy from the multicenter prospective skin cancer registry ADOREG. Study endpoints were best overall response (BOR), progression-free survival (PFS) and overall survival (OS). - Results - ALM patients had significantly higher rates of ulcerated tumors, loco regional metastases and fewer BRAF-mutated tumors compared to CM patients. Combined CPI was administered in 48.9% ALM patients and 39.3% of CM patients, while the remaining patients received PD-1 monotherapy. OS trended to be shorter in patients with ALM (18.1 vs. 43.8 months, p=0.10) with no significant differences in PFS (7.0 vs. 11.5 months, p=0.21). In patients with CM, median OS with combined CPI was not reached, whereas the median OS after PD-1 monotherapy was 37.8 months (p=0.22). Conversely, in patients with ALM, OS with combined CPI was 17.8 months, compared to 26 months with PD-1 monotherapy (p=0.15). There were no significant differences in BOR between patients with ALM or CM. - Conclusion - Analysis of this real-world cohort of patients with metastatic melanoma showed a trend towards poorer survival outcomes upon first-line treatment with CPI in ALM compared to cutaneous melanoma of other subtypes. 
540 |q DE-3  |a Namensnennung 4.0 International  |f CC BY 4.0  |2 cc  |u https://creativecommons.org/licenses/by/4.0/ 
650 4 |a Checkpoint inhibition 
650 4 |a Melanoma 
650 4 |a Response 
700 1 |a Utikal, Jochen  |d 1974-  |e VerfasserIn  |0 (DE-588)1026463750  |0 (DE-627)726765015  |0 (DE-576)371816580  |4 aut 
700 1 |a Zaremba, Anne  |e VerfasserIn  |4 aut 
700 1 |a Lodde, Georg  |e VerfasserIn  |4 aut 
700 1 |a von Wasielewski, Imke  |e VerfasserIn  |4 aut 
700 1 |a Klespe, Kai Christian  |e VerfasserIn  |4 aut 
700 1 |a Meier, Friedegund  |e VerfasserIn  |4 aut 
700 1 |a Haferkamp, Sebastian  |d 1978-  |e VerfasserIn  |0 (DE-588)132018330  |0 (DE-627)51684296X  |0 (DE-576)298896044  |4 aut 
700 1 |a Kähler, Katharina C.  |e VerfasserIn  |4 aut 
700 1 |a Herbst, Rudolf  |e VerfasserIn  |4 aut 
700 1 |a Gebhardt, Christoffer  |e VerfasserIn  |4 aut 
700 1 |a Sindrilaru, Anca  |e VerfasserIn  |4 aut 
700 1 |a Dippel, Edgar  |e VerfasserIn  |4 aut 
700 1 |a Angela, Yenny  |e VerfasserIn  |4 aut 
700 1 |a Mohr, Peter  |e VerfasserIn  |4 aut 
700 1 |a Pfoehler, Claudia  |e VerfasserIn  |4 aut 
700 1 |a Forschner, Andrea  |e VerfasserIn  |4 aut 
700 1 |a Kaatz, Martin  |e VerfasserIn  |4 aut 
700 1 |a Schell, Beatrice  |e VerfasserIn  |4 aut 
700 1 |a Gesierich, Anja  |e VerfasserIn  |4 aut 
700 1 |a Loquai, Carmen  |e VerfasserIn  |4 aut 
700 1 |a Hassel, Jessica C.  |d 1975-  |e VerfasserIn  |0 (DE-588)129790702  |0 (DE-627)480399069  |0 (DE-576)29783715X  |4 aut 
700 1 |a Ulrich, Jens  |e VerfasserIn  |4 aut 
700 1 |8 1\p  |a Meiß, Frank  |d 1975-  |e VerfasserIn  |0 (DE-588)128821825  |0 (DE-627)70707617X  |0 (DE-576)297349635  |4 aut 
700 1 |a Schley, Gaston  |e VerfasserIn  |4 aut 
700 1 |a Heinzerling, Lucie M.  |e VerfasserIn  |4 aut 
700 1 |a Sachse, Michael  |e VerfasserIn  |4 aut 
700 1 |8 2\p  |a Welzel, Julia  |d 1965-  |e VerfasserIn  |0 (DE-588)1111530866  |0 (DE-627)865606919  |0 (DE-576)476150647  |4 aut 
700 1 |a Weishaupt, Carsten  |d 1973-  |e VerfasserIn  |0 (DE-588)130499129  |0 (DE-627)502596430  |0 (DE-576)298232898  |4 aut 
700 1 |a Sunderkötter, Cord  |e VerfasserIn  |4 aut 
700 1 |a Michl, Christiane  |e VerfasserIn  |4 aut 
700 1 |a Lindhof, Harm-Henning  |e VerfasserIn  |4 aut 
700 1 |a Kreuter, Alexander  |d 1971-  |e VerfasserIn  |0 (DE-588)132383993  |0 (DE-627)521950546  |0 (DE-576)299112063  |4 aut 
700 1 |a Heppt, Markus V.  |d 1987-  |e VerfasserIn  |0 (DE-588)1072242346  |0 (DE-627)827081111  |0 (DE-576)43371767X  |4 aut 
700 1 |a Wenk, Saskia  |e VerfasserIn  |4 aut 
700 1 |a Mauch, Cornelia  |e VerfasserIn  |4 aut 
700 1 |a Berking, Carola  |e VerfasserIn  |4 aut 
700 1 |a Nedwed, Annekathrin Silvia  |e VerfasserIn  |4 aut 
700 1 |a Gutzmer, Ralf  |e VerfasserIn  |4 aut 
700 1 |a Leiter, Ulrike  |e VerfasserIn  |4 aut 
700 1 |a Schadendorf, Dirk  |d 1960-  |e VerfasserIn  |0 (DE-588)11142576X  |0 (DE-627)499566076  |0 (DE-576)289702275  |4 aut 
700 1 |a Ugurel, Selma  |d 1971-  |e VerfasserIn  |0 (DE-588)122030923  |0 (DE-627)081693532  |0 (DE-576)293057567  |4 aut 
700 1 |a Weichenthal, Michael  |e VerfasserIn  |0 (DE-588)140953272  |0 (DE-627)623003848  |0 (DE-576)321514157  |4 aut 
700 1 |a Haist, Maximilian  |e VerfasserIn  |4 aut 
700 1 |a Fleischer, Maria Isabel  |e VerfasserIn  |4 aut 
700 1 |a Lang, Berenice  |e VerfasserIn  |4 aut 
700 1 |a Grabbe, Stephan  |e VerfasserIn  |4 aut 
700 1 |a Stege, Henner  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t European journal of cancer  |d Amsterdam [u.a.] : Elsevier, 1992  |g 220(2025), Artikel-ID 115356, Seite 1-10  |w (DE-627)266883400  |w (DE-600)1468190-0  |w (DE-576)090954173  |x 1879-0852  |7 nnas  |a First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma a multicenter study from the prospective skin cancer registry ADOREG 
773 1 8 |g volume:220  |g year:2025  |g elocationid:115356  |g pages:1-10  |g extent:10  |a First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma a multicenter study from the prospective skin cancer registry ADOREG 
856 4 0 |u https://doi.org/10.1016/j.ejca.2025.115356  |x Resolving-System  |z kostenfrei 
856 4 0 |u https://doi.org/10.25673/119034  |x Resolving-System  |z kostenfrei 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0959804925001376  |x Verlag  |z kostenfrei  |3 Volltext 
883 |8 1\p  |a cgwrk  |d 20250604  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
883 |8 2\p  |a cgwrk  |d 20250604  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20250528 
993 |a Article 
994 |a 2025 
998 |g 122030923  |a Ugurel, Selma  |m 122030923:Ugurel, Selma  |d 60000  |e 60000PU122030923  |k 0/60000/  |p 42 
998 |g 11142576X  |a Schadendorf, Dirk  |m 11142576X:Schadendorf, Dirk  |d 50000  |e 50000PS11142576X  |k 0/50000/  |p 41 
998 |g 129790702  |a Hassel, Jessica C.  |m 129790702:Hassel, Jessica C.  |d 910000  |d 911300  |d 50000  |e 910000PH129790702  |e 911300PH129790702  |e 50000PH129790702  |k 0/910000/  |k 1/910000/911300/  |k 0/50000/  |p 22 
998 |g 1026463750  |a Utikal, Jochen  |m 1026463750:Utikal, Jochen  |d 60000  |e 60000PU1026463750  |k 0/60000/  |p 2 
999 |a KXP-PPN1926689909  |e 4728636011 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title_sort":"First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma","subtitle":"a multicenter study from the prospective skin cancer registry ADOREG","title":"First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma"}],"person":[{"family":"Reinhard","given":"Sören","role":"aut","display":"Reinhard, Sören"},{"given":"Jochen","role":"aut","display":"Utikal, Jochen","family":"Utikal"},{"role":"aut","given":"Anne","display":"Zaremba, Anne","family":"Zaremba"},{"family":"Lodde","role":"aut","given":"Georg","display":"Lodde, Georg"},{"given":"Imke","role":"aut","display":"von Wasielewski, Imke","family":"von Wasielewski"},{"family":"Klespe","display":"Klespe, Kai Christian","given":"Kai Christian","role":"aut"},{"display":"Meier, Friedegund","given":"Friedegund","role":"aut","family":"Meier"},{"family":"Haferkamp","display":"Haferkamp, Sebastian","role":"aut","given":"Sebastian"},{"family":"Kähler","display":"Kähler, Katharina C.","given":"Katharina C.","role":"aut"},{"display":"Herbst, Rudolf","given":"Rudolf","role":"aut","family":"Herbst"},{"family":"Gebhardt","display":"Gebhardt, Christoffer","given":"Christoffer","role":"aut"},{"family":"Sindrilaru","role":"aut","given":"Anca","display":"Sindrilaru, Anca"},{"display":"Dippel, Edgar","role":"aut","given":"Edgar","family":"Dippel"},{"given":"Yenny","role":"aut","display":"Angela, Yenny","family":"Angela"},{"family":"Mohr","role":"aut","given":"Peter","display":"Mohr, Peter"},{"display":"Pfoehler, Claudia","given":"Claudia","role":"aut","family":"Pfoehler"},{"family":"Forschner","display":"Forschner, Andrea","role":"aut","given":"Andrea"},{"family":"Kaatz","display":"Kaatz, Martin","given":"Martin","role":"aut"},{"family":"Schell","role":"aut","given":"Beatrice","display":"Schell, Beatrice"},{"role":"aut","given":"Anja","display":"Gesierich, Anja","family":"Gesierich"},{"given":"Carmen","role":"aut","display":"Loquai, Carmen","family":"Loquai"},{"family":"Hassel","given":"Jessica C.","role":"aut","display":"Hassel, Jessica C."},{"display":"Ulrich, Jens","given":"Jens","role":"aut","family":"Ulrich"},{"family":"Meiß","display":"Meiß, Frank","given":"Frank","role":"aut"},{"family":"Schley","display":"Schley, Gaston","role":"aut","given":"Gaston"},{"display":"Heinzerling, Lucie M.","given":"Lucie M.","role":"aut","family":"Heinzerling"},{"family":"Sachse","display":"Sachse, Michael","role":"aut","given":"Michael"},{"given":"Julia","role":"aut","display":"Welzel, Julia","family":"Welzel"},{"given":"Carsten","role":"aut","display":"Weishaupt, Carsten","family":"Weishaupt"},{"role":"aut","given":"Cord","display":"Sunderkötter, Cord","family":"Sunderkötter"},{"family":"Michl","given":"Christiane","role":"aut","display":"Michl, Christiane"},{"role":"aut","given":"Harm-Henning","display":"Lindhof, Harm-Henning","family":"Lindhof"},{"family":"Kreuter","display":"Kreuter, Alexander","role":"aut","given":"Alexander"},{"family":"Heppt","display":"Heppt, Markus V.","given":"Markus V.","role":"aut"},{"display":"Wenk, Saskia","role":"aut","given":"Saskia","family":"Wenk"},{"family":"Mauch","given":"Cornelia","role":"aut","display":"Mauch, Cornelia"},{"family":"Berking","display":"Berking, Carola","role":"aut","given":"Carola"},{"family":"Nedwed","role":"aut","given":"Annekathrin Silvia","display":"Nedwed, Annekathrin Silvia"},{"role":"aut","given":"Ralf","display":"Gutzmer, Ralf","family":"Gutzmer"},{"given":"Ulrike","role":"aut","display":"Leiter, Ulrike","family":"Leiter"},{"family":"Schadendorf","given":"Dirk","role":"aut","display":"Schadendorf, Dirk"},{"display":"Ugurel, Selma","role":"aut","given":"Selma","family":"Ugurel"},{"family":"Weichenthal","display":"Weichenthal, Michael","given":"Michael","role":"aut"},{"family":"Haist","role":"aut","given":"Maximilian","display":"Haist, Maximilian"},{"display":"Fleischer, Maria Isabel","given":"Maria Isabel","role":"aut","family":"Fleischer"},{"role":"aut","given":"Berenice","display":"Lang, Berenice","family":"Lang"},{"display":"Grabbe, Stephan","role":"aut","given":"Stephan","family":"Grabbe"},{"family":"Stege","role":"aut","given":"Henner","display":"Stege, Henner"}],"name":{"displayForm":["Sören Reinhard, Jochen Sven Utikal, Anne Zaremba, Georg Lodde, Imke von Wasielewski, Kai Christian Klespe, Friedegund Meier, Sebastian Haferkamp, Katharina C. Kähler, Rudolf Herbst, Christoffer Gebhardt, Anca Sindrilaru, Edgar Dippel, Yenny Angela, Peter Mohr, Claudia Pfoehler, Andrea Forschner, Martin Kaatz, Beatrice Schell, Anja Gesierich, Carmen Loquai, Jessica C. Hassel, Jens Ulrich, Frank Meiss, Gaston Schley, Lucie M. Heinzerling, Michael Sachse, Julia Welzel, Carsten Weishaupt, Cord Sunderkötter, Christiane Michl, Harm-Henning Lindhof, Alexander Kreuter, Markus V. Heppt, Saskia Wenk, Cornelia Mauch, Carola Berking, Annekathrin Silvia Nedwed, Ralf Gutzmer, Ulrike Leiter, Dirk Schadendorf, Selma Ugurel, Michael Weichenthal, Maximilian Haist, Maria Isabel Fleischer, Berenice Lang, Stephan Grabbe, Henner Stege"]},"note":["Online veröffentlicht: 15. März 2025, Artikelversion: 22. März 2025","Gesehen am 28.05.2025"],"relHost":[{"pubHistory":["28.1992 -"],"title":[{"title":"European journal of cancer","title_sort":"European journal of cancer"}],"language":["eng"],"part":{"volume":"220","year":"2025","text":"220(2025), Artikel-ID 115356, Seite 1-10","pages":"1-10","extent":"10"},"titleAlt":[{"title":"EJC online"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"266883400","origin":[{"publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1992","dateIssuedDisp":"1992-","publisher":"Elsevier ; Pergamon Press"}],"id":{"eki":["266883400"],"issn":["1879-0852"],"zdb":["1468190-0"]},"disp":"First-line checkpoint inhibitor therapy in metastatic acral lentiginous melanoma compared to other types of cutaneous melanoma a multicenter study from the prospective skin cancer registry ADOREGEuropean journal of cancer","note":["Gesehen am 21.03.24","Ungezählte Beil.: Supplement"],"corporate":[{"display":"European Organization for Research on Treatment of Cancer","role":"isb"},{"display":"European Association for Cancer Research","role":"isb"},{"role":"isb","display":"European School of Oncology"}]}],"physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}],"id":{"doi":["10.1016/j.ejca.2025.115356","10.25673/119034"],"eki":["1926689909"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"2 May 2025"}],"recId":"1926689909","type":{"bibl":"article-journal","media":"Online-Ressource"}} 
SRT |a REINHARDSOFIRSTLINEC2202 

Similar Items