Does transanal total mesorectal excision (taTME) result in better quality of life and functional outcomes than traditional TME does?: a retrospective propensity score-adjusted cohort study : research
Purpose The improved prognosis of rectal cancer through modern therapeutic approaches raises questions regarding quality of life (QoL) and functional outcomes. In this study, we compared post-transanal total mesorectal excision (taTME) short- and long-term QoL and functional outcomes with those afte...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 April 2025
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| In: |
Langenbeck's archives of surgery
Year: 2025, Jahrgang: 410, Pages: 1-12 |
| ISSN: | 1435-2451 |
| DOI: | 10.1007/s00423-025-03724-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00423-025-03724-6 Verlag, kostenfrei, Volltext: http://link.springer.com/article/10.1007/s00423-025-03724-6 |
| Verfasserangaben: | Yanic Ammann, Marie Klein, Lukas Marti, Rene Warschkow, Lennard Ströse, Moritz Sparn, Tarkan Jäger, Stephan Bischofberger, Walter Brunner |
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| 245 | 1 | 0 | |a Does transanal total mesorectal excision (taTME) result in better quality of life and functional outcomes than traditional TME does? |b a retrospective propensity score-adjusted cohort study : research |c Yanic Ammann, Marie Klein, Lukas Marti, Rene Warschkow, Lennard Ströse, Moritz Sparn, Tarkan Jäger, Stephan Bischofberger, Walter Brunner |
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| 520 | |a Purpose The improved prognosis of rectal cancer through modern therapeutic approaches raises questions regarding quality of life (QoL) and functional outcomes. In this study, we compared post-transanal total mesorectal excision (taTME) short- and long-term QoL and functional outcomes with those after abdominal TME (abTME). Methods Prospective data from patients who underwent elective taTME or abTME for stage I-III rectal cancer followed by anastomosis were retrospectively propensity score-adjusted. The primary endpoint, QoL, was assessed with the European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30). Functional outcomes were the secondary endpoints. Results Among 494 patients during 2013-2022, 187 patients who underwent taTME and 62 patients who underwent abTME were included. QoL was worse after taTME at isolated time points: overall QoL (after 3 years: 72 vs. 82 points, p = 0.017) and QLQ-total (after 3 years: 81 vs. 87 points, p = 0.028; after 4 years: 82 vs. 89 points, p = 0.012). After propensity score matching, the between-group differences were still significant but smaller: overall QoL − 6 points, p = 0.021; QLQ-total − 5 points, p = 0.026. Conclusion The differences reported at isolated time points have questionable clinical relevance. Therefore, taTME and traditional abTME seem to have comparable long-term QoL and functional outcomes. Clinical trial registration ClinicalTrials.gov, NCT06505863, https://clinicaltrials.gov/search?id=NCT06505863 . | ||
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