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Natural genetic variation quantitatively regulates heart rate and dimension

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The polygenic contribution to heart development and function along the health-disease continuum remains unresolved. To gain insight into the genetic basis of quantitative cardiac phenotypes, we utilize highly inbred Japanese rice fish models, Oryzias latipes, and Oryzias sakaizumii. Employing automa...

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Main Authors: Gierten, Jakob (Author) , Welz, Bettina (Author) , Fitzgerald, Tomas (Author) , Thumberger, Thomas (Author) , Agarwal, Rashi (Author) , Hummel, Oliver (Author) , Leger, Adrien (Author) , Weber, Philipp (Author) , Naruse, Kiyoshi (Author) , Hassel, David (Author) , Hübner, Norbert (Author) , Birney, Ewan (Author) , Wittbrodt, Joachim (Author)
Format: Article (Journal)
Language:English
Published: 30 April 2025
In: Nature Communications
Year: 2025, Volume: 16, Pages: 1-12
ISSN:2041-1723
DOI:10.1038/s41467-025-59425-7
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-59425-7
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-59425-7
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Author Notes:Jakob Gierten, Bettina Welz, Tomas Fitzgerald, Thomas Thumberger, Rashi Agarwal, Oliver Hummel, Adrien Leger, Philipp Weber, Kiyoshi Naruse, David Hassel, Norbert Hübner, Ewan Birney & Joachim Wittbrodt
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Natural genetic variation quantitatively regulates heart rate and dimension by Gierten, Jakob (Author) , Welz, Bettina (Author) , Fitzgerald, Tomas (Author) , Thumberger, Thomas (Author) , Hummel, Oliver (Author) , Leger, Adrien (Author) , Weber, Philipp (Author) , Hassel, David (Author) , Hübner, Norbert (Author) , Birney, Ewan (Author) , Wittbrodt, Joachim (Author) ,


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