Circulating amyloid beta 1-40 peptide as an associate of renal function decline
Background Recent evidence suggests that Alzheimer's amyloid-beta (1-40) (Αβ1-40), an emerging biomarker of cardiovascular disease, may be involved in the heart-brain-renal axis. We aimed to comprehensively explore the association between circulating Aβ1-40 levels and renal function and its cli...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
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| In: |
European journal of clinical investigation
Year: 2025, Jahrgang: 55, Heft: 5, Pages: 1-13 |
| ISSN: | 1365-2362 |
| DOI: | 10.1111/eci.70006 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/eci.70006 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.70006 
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| Verfasserangaben: | Georgios Mavraganis, Georgios Georgiopoulos, Georgios Zervas, Evmorfia Aivalioti, Dimitrios Delialis, Ioannis Petropoulos, Nikolaos Rachiotis, Christina Konstantaki, Chrysoula Moustou, Maria-Aggeliki Dimopoulou, Marco Sachse, Simon Tual-Chalot, Kateryna Sopova, Erasmia Psimmenou, Konstantinos Stellos, Kimon Stamatelopoulos |
MARC
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| 245 | 1 | 0 | |a Circulating amyloid beta 1-40 peptide as an associate of renal function decline |c Georgios Mavraganis, Georgios Georgiopoulos, Georgios Zervas, Evmorfia Aivalioti, Dimitrios Delialis, Ioannis Petropoulos, Nikolaos Rachiotis, Christina Konstantaki, Chrysoula Moustou, Maria-Aggeliki Dimopoulou, Marco Sachse, Simon Tual-Chalot, Kateryna Sopova, Erasmia Psimmenou, Konstantinos Stellos, Kimon Stamatelopoulos |
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| 520 | |a Background Recent evidence suggests that Alzheimer's amyloid-beta (1-40) (Αβ1-40), an emerging biomarker of cardiovascular disease, may be involved in the heart-brain-renal axis. We aimed to comprehensively explore the association between circulating Aβ1-40 levels and renal function and its clinical relevance. Methods Consecutively recruited subjects in the Athens Angiometabolic Registry with measured Aβ1-40 plasma levels (n = 811) were analysed. Αβ1-40 was measured by enzyme-linked immunosorbent assay and glomerular filtration rate (GFR) was calculated using the abbreviated four-variable Modification of Diet in Renal Disease (MDRD) formula. All-cause mortality was the main clinical endpoint across a median follow-up of 47 months. Results Cross-sectionally, a bidirectional association between Αβ1-40 [adjusted odds ratio (adjOR) = 3.67 for highest tertile of Αβ1-40 and chronic kidney disease (CKD) stage ≥3, p < .001] and CKD stage ≥3 (adjOR = 3.52 for association with highest Aβ1-40 tertile, p < .001) was observed. Longitudinally, increased Αβ1-40 at baseline was associated with decline in renal function at follow-up (adjOR for CKD stage ≥3 = 2.26, p = .033). Similarly, longitudinal changes in Aβ1-40 were inversely associated with changes in GFR (OR = .77 per 1 SD increase in Aβ1-40, p = .006). Aβ1-40 was associated with all-cause mortality, independently of traditional risk factors (hazard ratio = 1.20 per 1 SD increase in Aβ1-40, p = .016). An indirect effect of GFR on the association between Aβ1-40 and mortality (p < .05) with an estimated indirect-to-total effect ratio of .334, but not of Αβ1-40 on GFR with mortality, was observed. Conclusions In a population with a wide range of GFR, we found a bidirectional association between Αβ1-40 levels and renal function. The association of Αβ1-40 with all-cause mortality was partly mediated by lower GFR. | ||
| 650 | 4 | |a all-cause mortality | |
| 650 | 4 | |a amyloid Αβ1-40 | |
| 650 | 4 | |a glomerular filtration rate | |
| 650 | 4 | |a kidney function | |
| 650 | 4 | |a mediation analysis | |
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