Effects on neuroprotection and α-synuclein expression of a Canna coccinea rhizome extract
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated tha...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 January 2025
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| In: |
Fitoterapia
Year: 2025, Volume: 181, Pages: 1-7 |
| ISSN: | 1873-6971 |
| DOI: | 10.1016/j.fitote.2025.106380 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.fitote.2025.106380 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0367326X2500005X 
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| Author Notes: | Viviana G. Spotorno, Mariana Roxo, Bernhard Wetterauer, Osvaldo A. Zabal, Michael Wink |
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| 520 | |a Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly, currently with no cure. Its mechanisms are not well understood, however α-synuclein protein aggregation plays a central role in the pathogenesis of PD, leading to neurodegeneration. We demonstrated that in a PD model dietary in Caenorhabditis elegans treatment with an extract from the rhizome of Canna coccinea decreased the accumulation of α-synuclein. The extract showed low toxicity to neuro 2a cells and protected them from oxidative damage with H2O2 as a model for neurodegeneration. We studied the chemical profile of the extract using liquid chromatography couple to Mass Spectrometry. In order to characterize the herbal extract, we quantified rosmarinic acid as a marker compound and measured its antioxidant activity in vitro. Altogether, apart from its potential as a functional food, Canna coccinea may be an interesting source of secondary metabolites in the development of potential novel anti-neurodegenerative drugs. | ||
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