Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy

Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy - - IDENTIFYING SUITABLE CYTOSTATIC DRUGS FOR COMBINATORIAL IMMUNOTHERAPY The main dilemma in finding combinations of cytostatic and immunostimulatory drugs that act synerg...

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Bibliographic Details
Main Authors: Baumann, Daniel (Author) , Offringa, Rienk (Author)
Format: Article (Journal)
Language:English
Published: October 2020
In: Cell stress
Year: 2020, Volume: 4, Issue: 10, Pages: 248-251
ISSN:2523-0204
DOI:10.15698/cst2020.10.233
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.15698/cst2020.10.233
Verlag, kostenfrei, Volltext: https://www.cell-stress.com/researcharticles/2020a-baumann-cell-stress/
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Author Notes:Daniel Baumann and Rienk Offringa

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520 |a Targeting immune-checkpoint inhibitor resistance mechanisms by MEK inhibitor and agonist anti-CD40 antibody combination therapy - - IDENTIFYING SUITABLE CYTOSTATIC DRUGS FOR COMBINATORIAL IMMUNOTHERAPY The main dilemma in finding combinations of cytostatic and immunostimulatory drugs that act synergistically is as follows. On the one hand, the aim is to induce tumor cell death, not merely stasis, thereby feeding the immune system with tumor antigen. On the other hand, it is essential not to (...) 
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