Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI: an exploratory study
Automated tools have been proposed to quantify brain volume for suspected dementia diagnoses. However, their robustness in longitudinal, real-life cohorts remains unexplored. This exploratory study examined if expert visual assessment (EVA) of atrophy progression is reflected by automated volumetric...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 April 2025
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| In: |
Scientific reports
Year: 2025, Jahrgang: 15, Pages: 1-10 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-025-98360-x |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-98360-x Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41598-025-98360-x 
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| Verfasserangaben: | Max Gebest, Christel Weiß, Chang-Gyu Cho, Lucrezia Hausner, Lutz Frölich, Alex Förster, Nandhini Santhanam, Johann Fontana, Christoph Groden, Holger Wenz and Máté E. Maros |
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| 245 | 1 | 0 | |a Longitudinal automated brain volumetry versus expert visual assessment of atrophy progression on MRI |b an exploratory study |c Max Gebest, Christel Weiß, Chang-Gyu Cho, Lucrezia Hausner, Lutz Frölich, Alex Förster, Nandhini Santhanam, Johann Fontana, Christoph Groden, Holger Wenz and Máté E. Maros |
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| 520 | |a Automated tools have been proposed to quantify brain volume for suspected dementia diagnoses. However, their robustness in longitudinal, real-life cohorts remains unexplored. This exploratory study examined if expert visual assessment (EVA) of atrophy progression is reflected by automated volumetric analyses (AVA) on sequential MR-imaging. We analyzed a random subset of 20 patients with two consecutive 3D T1-weighted examinations (median follow-up 4.0 years, LQ-UQ: 2.1-5.2, range: 0.2-10). Thirteen (65%) with cognitive decline, the remaining with other neuropsychiatric diseases. EVA was performed by two blinded neuroradiologists using a 3 or 5-point Likert scale for atrophy progression (scores $$\pm$$0-2: no, probable and certain progression or decrease, respectively) in dementia-relevant brain regions (frontal-, parietal-, temporal lobes, hippocampi, ventricles). Differences of AVA-volumes were normalized to baseline (delta). Inter-rater agreement of EVA scores was excellent (κ = 0.92). AVA-delta and EVA showed significant global associations for the right hippocampus (pKW = 0.035), left temporal lobe (pKW = 0.0092), ventricle volume (pKW = 0.0091) and a weak association for the parietal lobe (pKW = 0.067). Post hoc testing revealed additional significant link for the left hippocampus (pWSRT = 0.039). In conclusion, the associations between volumetric deltas and EVA of atrophy progression showed promising results for certain brain regions. However, AVA-deltas exhibited unexpected variance, highlighting the need for caution and expert visual confirmation, particularly when scanners or acquisition protocols vary during follow-ups. Therefore, further validation, ideally in large prospective cohorts, is necessary before AVA can be recommended for routine clinical implementation in longitudinal follow-ups. | ||
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