Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease
Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identified a replication enhancing domain (ReED) in nonstructural protein 5A conferring high replication fitness to clinical isolates. Accumulation of mu...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) Kapitel/Artikel |
| Sprache: | Englisch |
| Veröffentlicht: |
09 Jun 2025
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| In: |
Research Square
Year: 2025, Pages: 1-31 |
| ISSN: | 2693-5015 |
| DOI: | 10.21203/rs.3.rs-6194507/v1 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.21203/rs.3.rs-6194507/v1 Verlag, kostenfrei, Volltext: https://www.researchsquare.com/article/rs-6194507/v1 |
| Verfasserangaben: | Volker Lohmann, Paul Rothhaar, Christian Heuss, Margaret Tulessin, Zhiqing Wang, Ha Gyu-Thomas Seong, Colin Förster, Jocelyn Quistrebert, Haiting Chai, Marvin Reineke, Louise Benning, Jonathan Honegger, Maike Hofmann, Robert Thimme, Jörg Timm, Graham Cooke, Paul Schnitzler, Uta Merle, Naglaa H. Shoukry, Julie Bruneau, Chaturaka Rodrigo, Andrew Lloyd, Rowena Bull, Azim Ansari, Carolin Mogler, John McLauchlan, Xavier Forns, Sofía Pérez-del-Pulgar |
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