Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine
In a randomized phase II trial (AMLSG 14-09, NCT00867672) of elderly, newly diagnosed AML patients, ATRA combined with decitabine (DEC) significantly improved the overall response rate (ORR) and survival also in patients with adverse-risk genetics, without adding toxicity. We performed a post hoc an...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 October 2024
|
| In: |
European journal of haematology
Year: 2025, Jahrgang: 114, Heft: 2, Pages: 231-237 |
| ISSN: | 1600-0609 |
| DOI: | 10.1111/ejh.14304 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ejh.14304 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.14304 
|
| Verfasserangaben: | Helena Bresser, Claudia Schmoor, Olga Grishina, Dietmar Pfeifer, Johanna Thomas, Usama-Ur Rehman, Martina Crysandt, Edgar Jost, Felicitas Thol, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Helmut R. Salih, Marcus M. Schittenhelm, Gerhard Heil, Carsten Schwaenen, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Annette M. May, Ralph Wäsch, Justus Duyster, Konstanze Döhner, Arnold Ganser, Hartmut Döhner, Björn Hackanson, Heiko Becker, Michael Lübbert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1927856043 | ||
| 003 | DE-627 | ||
| 005 | 20250710230843.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250610s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/ejh.14304 |2 doi | |
| 035 | |a (DE-627)1927856043 | ||
| 035 | |a (DE-599)KXP1927856043 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bresser, Helena |e VerfasserIn |0 (DE-588)1368275052 |0 (DE-627)192785752X |4 aut | |
| 245 | 1 | 0 | |a Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine |c Helena Bresser, Claudia Schmoor, Olga Grishina, Dietmar Pfeifer, Johanna Thomas, Usama-Ur Rehman, Martina Crysandt, Edgar Jost, Felicitas Thol, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Helmut R. Salih, Marcus M. Schittenhelm, Gerhard Heil, Carsten Schwaenen, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Annette M. May, Ralph Wäsch, Justus Duyster, Konstanze Döhner, Arnold Ganser, Hartmut Döhner, Björn Hackanson, Heiko Becker, Michael Lübbert |
| 264 | 1 | |c 13 October 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.06.2025 | ||
| 520 | |a In a randomized phase II trial (AMLSG 14-09, NCT00867672) of elderly, newly diagnosed AML patients, ATRA combined with decitabine (DEC) significantly improved the overall response rate (ORR) and survival also in patients with adverse-risk genetics, without adding toxicity. We performed a post hoc analysis to determine the predictive impact of TP53 status. Despite a nominally higher ORR, the clinically meaningful survival benefit when adding ATRA to DEC was diminished, but not completely negated, in TP53-mutated patients. Indeed, 2 out of 14 TP53-mutated patients (14%) randomized to a DEC + ATRA-containing regimen lived for > 36 months. Further studies of ATRA combined with hypomethylating agents appear warranted in non-M3 AML patients ineligible for HMA/venetoclax therapy. | ||
| 650 | 4 | |a AML | |
| 650 | 4 | |a ATRA | |
| 650 | 4 | |a epigenetics | |
| 650 | 4 | |a HMA | |
| 650 | 4 | |a TP53 | |
| 700 | 1 | |8 1\p |a Schmoor, Claudia |e VerfasserIn |0 (DE-588)1138584320 |0 (DE-627)896079406 |0 (DE-576)492586772 |4 aut | |
| 700 | 1 | |8 2\p |a Grishina, Olga |e VerfasserIn |0 (DE-588)1138451797 |0 (DE-627)896015580 |0 (DE-576)492545022 |4 aut | |
| 700 | 1 | |8 3\p |a Pfeifer, Dietmar |e VerfasserIn |0 (DE-588)1128163977 |0 (DE-627)882520997 |0 (DE-576)485714531 |4 aut | |
| 700 | 1 | |a Thomas, Johanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rehman, Usama-Ur |e VerfasserIn |4 aut | |
| 700 | 1 | |a Crysandt, Martina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jost, Edgar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thol, Felicitas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heuser, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Götze, Katharina S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlenk, Richard Friedrich |d 1965- |e VerfasserIn |0 (DE-588)129025380 |0 (DE-627)387778004 |0 (DE-576)297454102 |4 aut | |
| 700 | 1 | |a Salih, Helmut R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schittenhelm, Marcus M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heil, Gerhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwaenen, Carsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller-Tidow, Carsten |d 1968- |e VerfasserIn |0 (DE-588)1015101798 |0 (DE-627)705330230 |0 (DE-576)351197893 |4 aut | |
| 700 | 1 | |a Brugger, Wolfram |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kündgen, Andrea |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Wit, Maike |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giagounidis, Aristoteles |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scholl, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neubauer, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krauter, Jürgen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bug, Gesine |e VerfasserIn |4 aut | |
| 700 | 1 | |8 4\p |a May, Annette |e VerfasserIn |0 (DE-588)1156298288 |0 (DE-627)1018841466 |0 (DE-576)502081252 |4 aut | |
| 700 | 1 | |8 5\p |a Wäsch, Ralph |d 1965- |e VerfasserIn |0 (DE-588)118204807 |0 (DE-627)079304893 |0 (DE-576)291768458 |4 aut | |
| 700 | 1 | |8 6\p |a Duyster, Justus |d 1961- |e VerfasserIn |0 (DE-588)1119158060 |0 (DE-627)87245553X |0 (DE-576)400396130 |4 aut | |
| 700 | 1 | |a Döhner, Konstanze |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ganser, Arnold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Döhner, Hartmut |e VerfasserIn |4 aut | |
| 700 | 1 | |8 7\p |a Hackanson, Björn |d 1975- |e VerfasserIn |0 (DE-588)123946964 |0 (DE-627)706484479 |0 (DE-576)293954445 |4 aut | |
| 700 | 1 | |8 8\p |a Becker, Heiko |d 1978- |e VerfasserIn |0 (DE-588)1124562494 |0 (DE-627)878761993 |0 (DE-576)482834307 |4 aut | |
| 700 | 1 | |8 9\p |a Lübbert, Michael |e VerfasserIn |0 (DE-588)1054105367 |0 (DE-627)79104047X |0 (DE-576)409999768 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of haematology |d Oxford : Wiley-Blackwell, 1987 |g 114(2025), 2 vom: Feb., Seite 231-237 |h Online-Ressource |w (DE-627)320983463 |w (DE-600)2027114-1 |w (DE-576)093888864 |x 1600-0609 |7 nnas |a Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine |
| 773 | 1 | 8 | |g volume:114 |g year:2025 |g number:2 |g month:02 |g pages:231-237 |g extent:7 |a Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine |
| 856 | 4 | 0 | |u https://doi.org/10.1111/ejh.14304 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/ejh.14304 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 8\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 9\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250610 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1015101798 |a Müller-Tidow, Carsten |m 1015101798:Müller-Tidow, Carsten |d 910000 |d 910100 |e 910000PM1015101798 |e 910100PM1015101798 |k 0/910000/ |k 1/910000/910100/ | ||
| 998 | |g 129025380 |a Schlenk, Richard Friedrich |m 129025380:Schlenk, Richard Friedrich |d 910000 |d 910100 |e 910000PS129025380 |e 910100PS129025380 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 999 | |a KXP-PPN1927856043 |e 4732827748 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1111/ejh.14304"],"eki":["1927856043"]},"name":{"displayForm":["Helena Bresser, Claudia Schmoor, Olga Grishina, Dietmar Pfeifer, Johanna Thomas, Usama-Ur Rehman, Martina Crysandt, Edgar Jost, Felicitas Thol, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Helmut R. Salih, Marcus M. Schittenhelm, Gerhard Heil, Carsten Schwaenen, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Annette M. May, Ralph Wäsch, Justus Duyster, Konstanze Döhner, Arnold Ganser, Hartmut Döhner, Björn Hackanson, Heiko Becker, Michael Lübbert"]},"recId":"1927856043","physDesc":[{"extent":"7 S.","noteIll":"Illustrationen"}],"title":[{"title":"Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine","title_sort":"Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabine"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 10.06.2025"],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"13 October 2024"}],"person":[{"display":"Bresser, Helena","role":"aut","given":"Helena","family":"Bresser"},{"family":"Schmoor","given":"Claudia","role":"aut","display":"Schmoor, Claudia"},{"role":"aut","given":"Olga","family":"Grishina","display":"Grishina, Olga"},{"display":"Pfeifer, Dietmar","family":"Pfeifer","role":"aut","given":"Dietmar"},{"display":"Thomas, Johanna","family":"Thomas","role":"aut","given":"Johanna"},{"family":"Rehman","role":"aut","given":"Usama-Ur","display":"Rehman, Usama-Ur"},{"role":"aut","given":"Martina","family":"Crysandt","display":"Crysandt, Martina"},{"family":"Jost","given":"Edgar","role":"aut","display":"Jost, Edgar"},{"display":"Thol, Felicitas","family":"Thol","role":"aut","given":"Felicitas"},{"display":"Heuser, Michael","family":"Heuser","role":"aut","given":"Michael"},{"display":"Götze, Katharina S.","given":"Katharina S.","role":"aut","family":"Götze"},{"display":"Schlenk, Richard Friedrich","role":"aut","given":"Richard Friedrich","family":"Schlenk"},{"display":"Salih, Helmut R.","family":"Salih","role":"aut","given":"Helmut R."},{"display":"Schittenhelm, Marcus M.","given":"Marcus M.","role":"aut","family":"Schittenhelm"},{"role":"aut","given":"Gerhard","family":"Heil","display":"Heil, Gerhard"},{"family":"Schwaenen","role":"aut","given":"Carsten","display":"Schwaenen, Carsten"},{"family":"Müller-Tidow","given":"Carsten","role":"aut","display":"Müller-Tidow, Carsten"},{"display":"Brugger, Wolfram","role":"aut","given":"Wolfram","family":"Brugger"},{"display":"Kündgen, Andrea","family":"Kündgen","role":"aut","given":"Andrea"},{"display":"de Wit, Maike","role":"aut","given":"Maike","family":"de Wit"},{"family":"Giagounidis","given":"Aristoteles","role":"aut","display":"Giagounidis, Aristoteles"},{"display":"Scholl, Sebastian","role":"aut","given":"Sebastian","family":"Scholl"},{"display":"Neubauer, Andreas","given":"Andreas","role":"aut","family":"Neubauer"},{"family":"Krauter","role":"aut","given":"Jürgen","display":"Krauter, Jürgen"},{"family":"Bug","given":"Gesine","role":"aut","display":"Bug, Gesine"},{"display":"May, Annette","role":"aut","given":"Annette","family":"May"},{"role":"aut","given":"Ralph","family":"Wäsch","display":"Wäsch, Ralph"},{"given":"Justus","role":"aut","family":"Duyster","display":"Duyster, Justus"},{"display":"Döhner, Konstanze","given":"Konstanze","role":"aut","family":"Döhner"},{"role":"aut","given":"Arnold","family":"Ganser","display":"Ganser, Arnold"},{"display":"Döhner, Hartmut","family":"Döhner","role":"aut","given":"Hartmut"},{"family":"Hackanson","given":"Björn","role":"aut","display":"Hackanson, Björn"},{"display":"Becker, Heiko","role":"aut","given":"Heiko","family":"Becker"},{"display":"Lübbert, Michael","role":"aut","given":"Michael","family":"Lübbert"}],"relHost":[{"id":{"doi":["10.1111/(ISSN)1600-0609"],"zdb":["2027114-1"],"eki":["320983463"],"issn":["1600-0609"]},"title":[{"title_sort":"European journal of haematology","title":"European journal of haematology"}],"part":{"pages":"231-237","issue":"2","text":"114(2025), 2 vom: Feb., Seite 231-237","extent":"7","year":"2025","volume":"114"},"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 08.05.09"],"origin":[{"publisher":"Wiley-Blackwell ; Munksgaard ; Blackwell","dateIssuedKey":"1987","dateIssuedDisp":"1987-","publisherPlace":"Oxford ; Copenhagen ; Oxford [u.a.]"}],"pubHistory":["38.1987 -"],"disp":"Impact of TP53 mutation status in elderly AML patients when adding all-trans retinoic acid or valproic acid to decitabineEuropean journal of haematology","recId":"320983463","physDesc":[{"extent":"Online-Ressource"}]}]} | ||
| SRT | |a BRESSERHELIMPACTOFTP1320 | ||