Evaluation of current indirect methods for measuring LDL-cholesterol
Objectives Accurately quantifying low-density lipoprotein cholesterol (LDL-C) is crucial for precise cardiovascular disease risk assessment and treatment decisions. The commonly used Friedewald equation (LDL-C FW ) has faced criticism for its tendency to underestimate LDL-C, particularly at high tri...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1. Mai 2025
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| In: |
Clinical chemistry and laboratory medicine
Year: 2025, Jahrgang: 63, Heft: 6, Pages: 1099-1108 |
| ISSN: | 1437-4331 |
| DOI: | 10.1515/cclm-2025-0024 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1515/cclm-2025-0024 Verlag, lizenzpflichtig, Volltext: https://www.degruyterbrill.com/document/doi/10.1515/cclm-2025-0024/html 
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| Verfasserangaben: | Sophia Drobnik, Hubert Scharnagl, Nilesh J. Samani, Peter S. Braund, Christopher P. Nelson, Tim Hollstein, Ursula Kassner, Alexander Dressel, Wolfgang Drobnik und Winfried März |
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| 245 | 1 | 0 | |a Evaluation of current indirect methods for measuring LDL-cholesterol |c Sophia Drobnik, Hubert Scharnagl, Nilesh J. Samani, Peter S. Braund, Christopher P. Nelson, Tim Hollstein, Ursula Kassner, Alexander Dressel, Wolfgang Drobnik und Winfried März |
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| 520 | |a Objectives Accurately quantifying low-density lipoprotein cholesterol (LDL-C) is crucial for precise cardiovascular disease risk assessment and treatment decisions. The commonly used Friedewald equation (LDL-C FW ) has faced criticism for its tendency to underestimate LDL-C, particularly at high triglycerides (TG) or low LDL-C, potentially leading to undertreatment. Newer equations, such as those by Martin and Hopkins (LDL-C MH ) or Sampson (LDL-C SN ), have been proposed as alternatives. Our study aimed to assess the validity of LDL-C FW , LDL-C MH , and LDL-C SN compared to ß-quantification (LDL-C UC ), the reference method recommended by the Lipid Research Clinics. Methods Using data from three studies comprising 5,738 datasets, LDL-C was determined with the four methods in samples with TG up to 5.65mmol/L. We calculated median and mean differences, correlations, and used the Passing and Bablok regression for comparisons. Concordance/discordance analyses were conducted. Results All equations provided generally accurate LDL-C estimations with slight differences among them. At TG<1.69mmol/L, no clinically significant divergences were observed. As TG values increased, LDL-C FW offered the most accurate estimation, followed by LDL-C SN , while LDL-C MH exhibited increasingly strong positive bias. LDL-C FW was not inferior to LDL-C SN and LDL-C MH in terms of concordance/discordance. Conclusions LDL-C FW generally provided reliable estimates of LDL-C in most samples, showing non-inferiority to LDL-C SN or LDL-C MH , thereby confirming its legitimacy for routine use. Since current treatment recommendations are based on studies employing LDL-C FW , its replacement by alternatives is not justified. | ||
| 650 | 4 | |a beta quantification | |
| 650 | 4 | |a Friedewald equation | |
| 650 | 4 | |a low-density lipoprotein cholesterol | |
| 650 | 4 | |a Martin/Hopkins equation | |
| 650 | 4 | |a Sampson equation | |
| 700 | 1 | |a Scharnagl, Hubert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Samani, Nilesh J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Braund, Peter S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nelson, Christopher P. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hollstein, Tim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kassner, Ursula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dressel, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Drobnik, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
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