Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus
Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in life-threatening conditions with a large spectrum of pathology. Monoclonal antibody therapy has great potential especially to treat infections with virus resistan...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2024
|
| In: |
Journal of biomedical science
Year: 2024, Jahrgang: 31, Pages: 1-22$p22 |
| ISSN: | 1423-0127 |
| DOI: | 10.1186/s12929-024-01045-2 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12929-024-01045-2 Verlag, lizenzpflichtig, Volltext: https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01045-2 
|
| Verfasserangaben: | Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller and Michaela Arndt |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1927975832 | ||
| 003 | DE-627 | ||
| 005 | 20250611145041.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250611s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s12929-024-01045-2 |2 doi | |
| 035 | |a (DE-627)1927975832 | ||
| 035 | |a (DE-599)KXP1927975832 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Seyfizadeh, Narges |e VerfasserIn |0 (DE-588)1181446643 |0 (DE-627)166266995X |4 aut | |
| 245 | 1 | 0 | |a Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus |c Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller and Michaela Arndt |
| 264 | 1 | |c 2024 | |
| 300 | |b Illustrationen | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 28 May 2024 | ||
| 500 | |a Gesehen am 11.06.2025 | ||
| 520 | |a Infections with Herpes simplex virus (HSV)-1 or -2 usually present as mild chronic recurrent disease, however in rare cases can result in life-threatening conditions with a large spectrum of pathology. Monoclonal antibody therapy has great potential especially to treat infections with virus resistant to standard therapies. HDIT101, a humanized IgG targeting HSV-1/2 gB was previously investigated in phase 2 clinical trials. The aim of this study was to develop a next-generation therapy by combining different antiviral monoclonal antibodies. | ||
| 650 | 4 | |a Combination therapy | |
| 650 | 4 | |a Glycoprotein B (gB) | |
| 650 | 4 | |a Herpes simplex virus (HSV) | |
| 650 | 4 | |a Therapeutic monoclonal antibody | |
| 700 | 1 | |a Kalbermatter, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Imhof, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ries, Moritz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Müller, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jenner, Leonie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blumenschein, Elisabeth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yendrzheyevskiy, Alexandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grün, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Moog, Kevin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Eckert, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Engel, Ronja |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diebolder, Philipp |e VerfasserIn |0 (DE-588)1103034138 |0 (DE-627)860639975 |0 (DE-576)470438045 |4 aut | |
| 700 | 1 | |a Chami, Mohamed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krauß, Jürgen |d 1960- |e VerfasserIn |0 (DE-588)120665301 |0 (DE-627)70490778X |0 (DE-576)292329083 |4 aut | |
| 700 | 1 | |a Schaller, Torsten |e VerfasserIn |0 (DE-588)1155841174 |0 (DE-627)1018325425 |0 (DE-576)501895574 |4 aut | |
| 700 | 1 | |a Arndt, Michaela |e VerfasserIn |0 (DE-588)1084612712 |0 (DE-627)848572076 |0 (DE-576)456369635 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of biomedical science |d London : BioMed Central, 1994 |g 31(2024), Artikel-ID 56, Seite 1-22$p22 |h Online-Ressource |w (DE-627)300593724 |w (DE-600)1482918-6 |w (DE-576)118613995 |x 1423-0127 |7 nnas |a Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus |
| 773 | 1 | 8 | |g volume:31 |g year:2024 |g elocationid:56 |g pages:1-22$p22 |a Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s12929-024-01045-2 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-024-01045-2 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250611 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 120665301 |a Krauß, Jürgen |m 120665301:Krauß, Jürgen |d 50000 |e 50000PK120665301 |k 0/50000/ |p 15 | ||
| 999 | |a KXP-PPN1927975832 |e 4733202938 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus","title_sort":"Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus"}],"person":[{"role":"aut","given":"Narges","roleDisplay":"VerfasserIn","display":"Seyfizadeh, Narges","family":"Seyfizadeh"},{"roleDisplay":"VerfasserIn","display":"Kalbermatter, David","family":"Kalbermatter","role":"aut","given":"David"},{"roleDisplay":"VerfasserIn","family":"Imhof","display":"Imhof, Thomas","role":"aut","given":"Thomas"},{"given":"Moritz","role":"aut","display":"Ries, Moritz","family":"Ries","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Müller, Christian","family":"Müller","given":"Christian","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Jenner","display":"Jenner, Leonie","given":"Leonie","role":"aut"},{"role":"aut","given":"Elisabeth","family":"Blumenschein","display":"Blumenschein, Elisabeth","roleDisplay":"VerfasserIn"},{"role":"aut","given":"Alexandra","display":"Yendrzheyevskiy, Alexandra","family":"Yendrzheyevskiy","roleDisplay":"VerfasserIn"},{"given":"Frank","role":"aut","display":"Grün, Frank","family":"Grün","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Moog, Kevin","family":"Moog","given":"Kevin","role":"aut"},{"role":"aut","given":"Daniel","family":"Eckert","display":"Eckert, Daniel","roleDisplay":"VerfasserIn"},{"given":"Ronja","role":"aut","family":"Engel","display":"Engel, Ronja","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Diebolder","display":"Diebolder, Philipp","role":"aut","given":"Philipp"},{"roleDisplay":"VerfasserIn","display":"Chami, Mohamed","family":"Chami","role":"aut","given":"Mohamed"},{"roleDisplay":"VerfasserIn","family":"Krauß","display":"Krauß, Jürgen","role":"aut","given":"Jürgen"},{"roleDisplay":"VerfasserIn","display":"Schaller, Torsten","family":"Schaller","role":"aut","given":"Torsten"},{"family":"Arndt","display":"Arndt, Michaela","roleDisplay":"VerfasserIn","given":"Michaela","role":"aut"}],"note":["Veröffentlicht: 28 May 2024","Gesehen am 11.06.2025"],"recId":"1927975832","physDesc":[{"noteIll":"Illustrationen"}],"language":["eng"],"id":{"eki":["1927975832"],"doi":["10.1186/s12929-024-01045-2"]},"relHost":[{"origin":[{"publisherPlace":"London ; Basel ; Dordrecht","dateIssuedKey":"1994","dateIssuedDisp":"1994-","publisher":"BioMed Central ; Karger ; Springer Science + Business Media B.V."}],"pubHistory":["1.1993/94 -"],"disp":"Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virusJournal of biomedical science","name":{"displayForm":["sponsored by the National Science Council, Taipei"]},"part":{"year":"2024","volume":"31","text":"31(2024), Artikel-ID 56, Seite 1-22$p22","pages":"1-22$p22"},"corporate":[{"role":"isb","display":"Guo jia ke xue wei yuan hui","roleDisplay":"Herausgebendes Organ"}],"id":{"issn":["1423-0127"],"zdb":["1482918-6"],"eki":["300593724"]},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"300593724","titleAlt":[{"title":"Biomedical science"}],"note":["Gesehen am 09.05.2019"],"title":[{"title_sort":"Journal of biomedical science","title":"Journal of biomedical science","subtitle":"an international and Asian forum for high-impact biomedical research"}],"type":{"bibl":"periodical","media":"Online-Ressource"}}],"name":{"displayForm":["Narges Seyfizadeh, David Kalbermatter, Thomas Imhof, Moritz Ries, Christian Müller, Leonie Jenner, Elisabeth Blumenschein, Alexandra Yendrzheyevskiy, Frank Grün, Kevin Moog, Daniel Eckert, Ronja Engel, Philipp Diebolder, Mohamed Chami, Jürgen Krauss, Torsten Schaller and Michaela Arndt"]},"origin":[{"dateIssuedKey":"2024","dateIssuedDisp":"2024"}]} | ||
| SRT | |a SEYFIZADEHDEVELOPMEN2024 | ||