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The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression: comparative interobserver study

The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47...

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Hauptverfasser: Lütgendorf-Caucig, Carola (VerfasserIn) , Wieland, Patricia (VerfasserIn) , Hug, Eugen (VerfasserIn) , Flechl, Birgit (VerfasserIn) , Tubin, Slavisa (VerfasserIn) , Galalae, Razvan (VerfasserIn) , Georg, Petra (VerfasserIn) , Fossati, Piero (VerfasserIn) , Mumot, Marta (VerfasserIn) , Harrabi, Semi B. (VerfasserIn) , Pradler, Irina (VerfasserIn) , Pelak, Maciej J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 May 2024
In: Cancers
Year: 2024, Jahrgang: 16, Heft: 10, Pages: 1-10
ISSN:2072-6694
DOI:10.3390/cancers16101877
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16101877
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/10/1877
Volltext
Verfasserangaben:Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak
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Zusammenfassung:The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation.
Beschreibung:Gesehen am 11.06.2025
Beschreibung:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers16101877

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