The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression: comparative interobserver study
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 May 2024
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| In: |
Cancers
Year: 2024, Jahrgang: 16, Heft: 10, Pages: 1-10 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16101877 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16101877 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/10/1877 
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| Verfasserangaben: | Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak |
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| 100 | 1 | |a Lütgendorf-Caucig, Carola |e VerfasserIn |0 (DE-588)1368418694 |0 (DE-627)1927981859 |4 aut | |
| 245 | 1 | 4 | |a The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression |b comparative interobserver study |c Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak |
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| 520 | |a The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. | ||
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