The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression: comparative interobserver study
The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 May 2024
|
| In: |
Cancers
Year: 2024, Volume: 16, Issue: 10, Pages: 1-10 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers16101877 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers16101877 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/16/10/1877 
|
| Author Notes: | Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1927980496 | ||
| 003 | DE-627 | ||
| 005 | 20251127233203.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250611s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/cancers16101877 |2 doi | |
| 035 | |a (DE-627)1927980496 | ||
| 035 | |a (DE-599)KXP1927980496 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lütgendorf-Caucig, Carola |e VerfasserIn |0 (DE-588)1368418694 |0 (DE-627)1927981859 |4 aut | |
| 245 | 1 | 4 | |a The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression |b comparative interobserver study |c Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak |
| 264 | 1 | |c 15 May 2024 | |
| 300 | |b Illustrationen | ||
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.06.2025 | ||
| 520 | |a The overexpression of somatostatin receptor type 2 (SSTR2) is a property of various tumor types. Hybrid imaging utilizing [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) may improve the differentiation between tumor and healthy tissue. We conducted an experimental study on 47 anonymized patient cases including 30 meningiomas, 12 PitNET and 5 SBPGL. Four independent observers were instructed to contour the macroscopic tumor volume on planning MRI and then reassess their volumes with the additional information from DOTA-PET/CT. The conformity between observers and reference volumes was assessed. In total, 46 cases (97.9%) were DOTA-avid and included in the final analysis. In eight cases, PET/CT additional tumor volume was identified that was not detected by MRI; these PET/CT findings were potentially critical for the treatment plan in four cases. For meningiomas, the interobserver and observer to reference volume conformity indices were higher with PET/CT. For PitNET, the volumes had higher conformity between observers with MRI. With regard to SBGDL, no significant trend towards conformity with the addition of PET/CT information was observed. DOTA PET/CT supports accurate tumor recognition in meningioma and PitNET and is recommended in SSTR2-expressing tumors planned for treatment with highly conformal radiation. | ||
| 650 | 4 | |a contouring | |
| 650 | 4 | |a DOTA | |
| 650 | 4 | |a glomus tympanicum tumor | |
| 650 | 4 | |a interobserver variability | |
| 650 | 4 | |a meningioma | |
| 650 | 4 | |a PET/CT | |
| 650 | 4 | |a PitNET | |
| 650 | 4 | |a proton therapy | |
| 700 | 1 | |a Wieland, Patricia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hug, Eugen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Flechl, Birgit |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Tubin, Slavisa |e VerfasserIn |0 (DE-588)1349758736 |0 (DE-627)1909915831 |4 aut | |
| 700 | 1 | |8 2\p |a Galalae, Razvan |d 1962- |e VerfasserIn |0 (DE-588)121885437 |0 (DE-627)081598343 |0 (DE-576)292937768 |4 aut | |
| 700 | 1 | |a Georg, Petra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fossati, Piero |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mumot, Marta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harrabi, Semi B. |d 1986- |e VerfasserIn |0 (DE-588)1044730161 |0 (DE-627)772596034 |0 (DE-576)398081298 |4 aut | |
| 700 | 1 | |8 3\p |a Pradler, Irina |e VerfasserIn |0 (DE-588)1311631518 |0 (DE-627)1871602289 |4 aut | |
| 700 | 1 | |a Pelak, Maciej J. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancers |d Basel : MDPI, 2009 |g 16(2024), 10, Artikel-ID 1877, Seite 1-10 |h Online-Ressource |w (DE-627)614095670 |w (DE-600)2527080-1 |w (DE-576)313958548 |x 2072-6694 |7 nnas |a The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression comparative interobserver study |
| 773 | 1 | 8 | |g volume:16 |g year:2024 |g number:10 |g elocationid:1877 |g pages:1-10 |g extent:10 |a The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression comparative interobserver study |
| 856 | 4 | 0 | |u https://doi.org/10.3390/cancers16101877 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2072-6694/16/10/1877 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20251101 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20250701 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250611 | ||
| 993 | |a Article | ||
| 994 | |a 2024 | ||
| 998 | |g 1044730161 |a Harrabi, Semi B. |m 1044730161:Harrabi, Semi B. |d 910000 |d 911400 |d 50000 |e 910000PH1044730161 |e 911400PH1044730161 |e 50000PH1044730161 |k 0/910000/ |k 1/910000/911400/ |k 0/50000/ |p 10 | ||
| 999 | |a KXP-PPN1927980496 |e 4733218346 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression","subtitle":"comparative interobserver study","title":"The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression"}],"person":[{"display":"Lütgendorf-Caucig, Carola","role":"aut","given":"Carola","family":"Lütgendorf-Caucig"},{"display":"Wieland, Patricia","given":"Patricia","role":"aut","family":"Wieland"},{"role":"aut","given":"Eugen","display":"Hug, Eugen","family":"Hug"},{"role":"aut","given":"Birgit","display":"Flechl, Birgit","family":"Flechl"},{"given":"Slavisa","role":"aut","display":"Tubin, Slavisa","family":"Tubin"},{"family":"Galalae","role":"aut","given":"Razvan","display":"Galalae, Razvan"},{"family":"Georg","display":"Georg, Petra","role":"aut","given":"Petra"},{"role":"aut","given":"Piero","display":"Fossati, Piero","family":"Fossati"},{"role":"aut","given":"Marta","display":"Mumot, Marta","family":"Mumot"},{"family":"Harrabi","role":"aut","given":"Semi B.","display":"Harrabi, Semi B."},{"family":"Pradler","display":"Pradler, Irina","given":"Irina","role":"aut"},{"family":"Pelak","display":"Pelak, Maciej J.","role":"aut","given":"Maciej J."}],"name":{"displayForm":["Carola Lütgendorf-Caucig, Patricia Wieland, Eugen Hug, Birgit Flechl, Slavisa Tubin, Razvan Galalae, Petra Georg, Piero Fossati, Marta Mumot, Semi Harrabi, Irina Pradler and Maciej J. Pelak"]},"relHost":[{"title":[{"title":"Cancers","title_sort":"Cancers"}],"language":["eng"],"part":{"volume":"16","text":"16(2024), 10, Artikel-ID 1877, Seite 1-10","year":"2024","extent":"10","pages":"1-10","issue":"10"},"pubHistory":["1.2009 -"],"name":{"displayForm":["Molecular Diversity Preservation International (MDPI)"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"publisherPlace":"Basel","dateIssuedKey":"2009","publisher":"MDPI","dateIssuedDisp":"2009-"}],"recId":"614095670","disp":"The value of PET/CT in particle therapy planning of various tumors with SSTR2 receptor expression comparative interobserver studyCancers","id":{"eki":["614095670"],"zdb":["2527080-1"],"issn":["2072-6694"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 27.05.2020"]}],"note":["Gesehen am 11.06.2025"],"id":{"doi":["10.3390/cancers16101877"],"eki":["1927980496"]},"physDesc":[{"noteIll":"Illustrationen","extent":"10 S."}],"origin":[{"dateIssuedDisp":"15 May 2024","dateIssuedKey":"2024"}],"recId":"1927980496","type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a LUETGENDORVALUEOFPET1520 | ||